EP1210102A4

Tgf-alpha polypeptides, functional fragments and methods of use therefor

Abstract

This record has no abstract on file.

EP1210102A4, drawing sheet 1 — Sheet 1 of 6

Term

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Projected expiry passed 17 August 2020, 6.1 years ago.

6 sheets

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Sheet 2
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Sheet 5
Sheet 6

Every citation, both waysCites: the store holds 16 of 17

Citations
Document	Relation	Office	Category	Cited during	Relevant claims
WO0044400A1	Cites	World Intellectual Property Organization (WIPO)	PX	Search report	1-29
WO0065028A2	Cites	World Intellectual Property Organization (WIPO)	E	Search report	1-29
WO03016480A2	Cites	World Intellectual Property Organization (WIPO)	E	Search report	1-29
US5102870A	Cites	United States of America	X	Search report	1-16,24-29
US5240912A	Cites	United States of America	X	Search report	1-16,24-29
US5750376A	Cites	United States of America	X	Search report	1-29
US5885956A	Cites	United States of America	X	Search report	1-29
WO9519785A1	Cites	World Intellectual Property Organization (WIPO)	X	Search report	1-29
WO9819712A1	Cites	World Intellectual Property Organization (WIPO)	X	Search report	1-29
WO9956785A2	Cites	World Intellectual Property Organization (WIPO)	PX	Search report	1-29
WO9819712A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
WO9956785A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
WO9519785A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
WO0044400A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
WO0065028A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
WO03016480A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
ROMANO M ET AL: "TRANSFORMING GROWTH FACTOR ALPHA PROTECTION AGAINST DRUG-INDUCED INJURY TO THE RAT GASTRIC MUCOSA IN VIVO", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 90, no. 6, December 1992 (1992-12-01), pages 2409 - 2421, XP009009478, ISSN: 0021-9738	Non-patent	–	–	Search report	–
EGGER B ET AL: "REDUCED SUSCEPTIBILITY OF MICE OVEREXPRESSING TRANSFORMING GROWTH FACTOR ALPHA TO DEXTRAN SODIUM SULPHATE INDUCED COLITIS", GUT, BRITISH MEDICAL ASSOCIATION, LONDON,, GB, vol. 43, no. 1, July 1998 (1998-07-01), pages 64 - 70, XP009009470, ISSN: 0017-5749	Non-patent	–	–	Search report	–
SHARP RICHARD ET AL: "Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice", DEVELOPMENT (CAMBRIDGE), vol. 121, no. 1, 1995, pages 149 - 161, XP002267337, ISSN: 0950-1991	Non-patent	–	–	Search report	–
BECK P L ET AL: "GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE", INFLAMMATORY BOWEL DISEASES, WILLAMS AND WILKINS, HAGERSTOWN, MD,, US, vol. 5, no. 1, 1999, pages 44 - 60, XP000929625, ISSN: 1078-0998	Non-patent	–	–	Search report	–
HUANG F S ET AL: "ROLE OF EPIDERMAL GROWTH FACTOR AND ITS RECEPTOR IN CHEMOTHERAPY-INDUCED INTESTINAL INJURY", AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 282, no. 3, March 2002 (2002-03-01), pages G432 - G442, XP001079303, ISSN: 0193-1857	Non-patent	–	–	Search report	–
JUSTICIA C ET AL: "TRANSFORMING GROWTH FACTOR-ALPHA ACTING AT THE EPIDERMAL GROWTH FACTOR RECEPTOR REDUCES INFARCT VOLUME AFTER PERMANENT MIDDLE CEREBRAL ARTERY OCCLUSION IN RATS", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, RAVEN PRESS, LTD., NEW YORK, NY, US, vol. 19, no. 2, February 1999 (1999-02-01), pages 128 - 132, XP001083891, ISSN: 0271-678X	Non-patent	–	–	Search report	–
YAMASHITA H ET AL: "INDUCTION OF CELL PROFILERATION IN MAMMALIAN INNER-EAR SENSORY EPITHELIA BY TRANSFORMING GROWTH FACTOR A AND EPIDERMAL GROWTH FACTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, 1995, pages 3152 - 3155, XP000882869, ISSN: 0027-8424	Non-patent	–	–	Search report	–
SONG S Y ET AL: "Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha", GASTROENTEROLOGY, SAUNDERS, PHILADELPHIA, PA,, US, vol. 117, December 1999 (1999-12-01), pages 1416 - 1426, XP002953994, ISSN: 0016-5085	Non-patent	–	–	Search report	–
HUOTARI M-A ET AL: "GROWTH FACTOR-MEDIATED PROLIFERATION AND DIFFERENTIATION OF INSULIN-PRODUCING INS-1 AND RINM5F CELLS: IDENTIFICATION OF BETACELLULIN AS A NOVEL BETA-CELL MITOGEN", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 139, no. 4, 1998, pages 1494 - 1499, XP000917303, ISSN: 0013-7227	Non-patent	–	–	Search report	–
GANDRILLON OLIVIER ET AL: "TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: Evidence for an autocrine mechanism.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 18, no. 10, 17 May 1999 (1999-05-17), pages 2764 - 2781, XP002248244, ISSN: 0261-4189	Non-patent	–	–	Search report	–
CASHMAN J D ET AL: "MECHANISMS THAT REGULATE THE CELL CYCLE STATUS OF VERY PRIMITIVE HEMATOPOIETIC CELLS IN LONG-TERM HUMAN MARROW CULTURES. I. STIMULATORY ROLE OF A VARIETY OF MESENCHYMAL CELL ACTIVATORS AND INHIBITORY ROLE OF TGF-BETA", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 75, no. 1, 1 January 1990 (1990-01-01), pages 96 - 101, XP009014172, ISSN: 0006-4971	Non-patent	–	–	Search report	–
HAYMAN M J ET AL: "SELF-RENEWAL AND DIFFERENTIATION OF NORMAL AVIAN ERYTHROID PROGENITOR CELLS: REGULATORY ROLES OF THE TGFALPHA/C-ERBB AND SCF/C-KIT RECEPTORS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 74, no. 1, 16 July 1993 (1993-07-16), pages 157 - 169, XP001153817, ISSN: 0092-8674	Non-patent	–	–	Search report	–
WALZ T M ET AL: "TRANSFORMING GROWTH FACTOR-ALPHA (TGF-ALPHA) IN HUMAN BONE MARROW: DEMONSTRATION OF TGF-ALPHA IN ERYTHROBLASTS AND EOSINOPHILIC PRECURSOR CELLS AND OF EPIDERMAL GROWTH FACTOR RECEPTORS IN BLASTLIKE CELLS OF MYELOMONOCYTIC ORIGIN", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 85, no. 9, 1 May 1995 (1995-05-01), pages 2385 - 2392, XP009014171, ISSN: 0006-4971	Non-patent	–	–	Search report	–
See also references of WO 0112127A3	Non-patent	–	–	Search report	–

44 members in 8 offices

This recordMember, by publication datePriority claim

Priority claims24

Priority claims
Document	Office	Kind	Date
378567	United States of America	–	1999-08-19
37856799	United States of America	A	1999-08-19
37856799	United States of America	A	1999-08-19
459813	United States of America	–	1999-12-13
45981399	United States of America	A	1999-12-13
45981399	United States of America	A	1999-12-13
492935	United States of America	–	2000-01-27
49293500	United States of America	A	2000-01-27
49293500	United States of America	A	2000-01-27
559248	United States of America	–	2000-04-26
55924800	United States of America	A	2000-04-26
55924800	United States of America	A	2000-04-26
0022882	United States of America	W	2000-08-17
0022882	United States of America	W	2000-08-17
378567	–	–	–
459813	–	–	–
492935	–	–	–
559248	–	–	–
US19990378567	–	–	–
US19990459813	–	–	–
US2000022882	–	–	–
US20000492935	–	–	–
US20000559248	–	–	–
WO2000US22882	–	–	–

Members44

Family members, oldest first
Document	Office	Kind
CA2371241A1	Canada	A1	2000-11-02
WO0065028A2	World Intellectual Property Organization (WIPO)	A2	2000-11-02
AU4679300A	Australia	A	2000-11-10
CA2380635A1	Canada	A1	2001-02-22
WO0112127A2	World Intellectual Property Organization (WIPO)	A2	2001-02-22
AU6920800A	Australia	A	2001-03-13
WO0065028A3	World Intellectual Property Organization (WIPO)	A3	2001-05-03
WO0112127A3	World Intellectual Property Organization (WIPO)	A3	2001-08-30
WO0112127B1	World Intellectual Property Organization (WIPO)	B1	2001-09-27
EP1176870A2	European Patent Office (EPO)	A2	2002-02-06
WO0065028A9	World Intellectual Property Organization (WIPO)	A9	2002-03-14
EP1210102A2	European Patent Office (EPO)	A2	2002-06-05
US2002099008A1	United States of America	A1	2002-07-25
EP1176870A4	European Patent Office (EPO)	A4	2002-07-31
US2002123465A1	United States of America	A1	2002-09-05
US2002169119A1	United States of America	A1	2002-11-14
US2002169131A1	United States of America	A1	2002-11-14
US6486122B1	United States of America	B1	2002-11-26
JP2002543096A	Japan	A	2002-12-17
US2002193301A1	United States of America	A1	2002-12-19
US2003036509A1	United States of America	A1	2003-02-20
WO03016480A2	World Intellectual Property Organization (WIPO)	A2	2003-02-27
AU2002336355A1	Australia	A1	2003-03-03
JP2003522131A	Japan	A	2003-07-22
WO03092724A1	World Intellectual Property Organization (WIPO)	A1	2003-11-13
AU2003228802A1	Australia	A1	2003-11-17
US6677307B2	United States of America	B2	2004-01-13
EP1210102A4This record	European Patent Office (EPO)	A4	2004-03-31
US6764683B1	United States of America	B1	2004-07-20
US6815418B2	United States of America	B2	2004-11-09
WO03016480A3	World Intellectual Property Organization (WIPO)	A3	2004-11-11
US2006105957A1	United States of America	A1	2006-05-18
EP1176870B1	European Patent Office (EPO)	B1	2007-06-13
AT364315T	Austria	T	2007-07-15
DE60035192D1	Germany	D1	2007-07-26
US7329645B2	United States of America	B2	2008-02-12
DE60035192T2	Germany	T2	2008-02-14
EP1897441A1	European Patent Office (EPO)	A1	2008-03-12
US7365172B2	United States of America	B2	2008-04-29
US2008242611A1	United States of America	A1	2008-10-02
US2009068139A1	United States of America	A1	2009-03-12
EP1210102B1	European Patent Office (EPO)	B1	2010-04-07
AT463251T	Austria	T	2010-04-15
DE60044136D1	Germany	D1	2010-05-20

46 legal events, as 7 offices reported them to INPADOC

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	Event	Code	Office
2012-09-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-05-18	Notification of lapseLapsedST	ST	FR
2011-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-07-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-07-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-06-22	Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal feeWithdrawnR119	R119	DE
2011-04-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-04-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-04-27	Gb: european patent ceased through non-payment of renewal feeCeasedGBPC	GBPC	EP
2011-03-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-03-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-03-31	Patent ceasedCeasedPL	PL	CH
2011-03-16	No opposition filedOpposition26N	26N	EP
2011-02-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-02-11	No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE	PLBE	EP
2011-02-11	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA	STAA	EP
2011-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-12-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-12-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-11-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-11-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-11-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2010-10-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-10-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-10-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-07-28	Discontinued in the netherlands as no translation has been filedVDEP	VDEP	NL
2010-05-20	Corresponds to:REF	REF	EP
2010-05-12	European patents granted designating irelandGrantedFG4D	FG4D	IE
2010-04-15	European patent takes effect as a national patent in ch/liEP	EP	CH
2010-04-07	Designated contracting statesAK	AK	EP
2010-04-07	European patent grantedGrantedFG4D	FG4D	GB
2010-03-05	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
2009-07-29	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1	EP
2009-07-28	Grant fee paidORIGINAL CODE: EPIDOSNIGR3GRAS	GRAS	EP
2009-03-14	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOSNIGR1GRAP	GRAP	EP
2006-12-13	First examination report despatched17Q	17Q	EP
2004-03-31	Supplementary search report drawn up and despatchedA4	A4	EP
2004-03-17	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2004-03-17	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2004-03-17	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2002-06-05	Request for examination filed17P	17P	EP
2002-06-05	Designated contracting statesAK	AK	EP
2002-06-05	Request for extension of the european patentAL;LT;LV;MK;RO;SIAX	AX	EP
2002-04-19	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Tgf-alpha polypeptides, functional fragments and methods of use therefor

Abstract

Term

Priority claims24

Members44

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Events

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Titles3

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Designated states2