Preparations of W/O emulsion typewith high water content, further containing one or more alkyl methicone copolyol and/or alkyl dimethicone copolyol

The present invention relates to cosmetic and dermatological preparations, in particular those of the water-in-oil type, to processes for their preparation and to their use for cosmetic and medical purposes.

Human skin, as the largest human organ, performs many vital functions. With an average of about 2 m² Surface in adults plays a prominent role as a protective and sensory organ. The task of this organ is to mediate and ward off mechanical, thermal, actinic, chemical and biological stimuli. In addition, it plays an important role as regulatory and target organ in human metabolism.

Cosmetic skincare is primarily understood to strengthen or restore the natural function of the skin as a barrier against environmental influences (eg dirt, chemicals, microorganisms) and against the loss of endogenous substances (eg water, natural fats, electrolytes) and their horny layer to assist in the event of damage occurring in their natural regeneration capacity.

If the barrier properties of the skin are disturbed, increased absorption of toxic or allergenic substances or infestation of microorganisms and, as a consequence, toxic or allergic skin reactions may occur.

The aim of skin care is also to compensate for the daily loss of fat and water loss of the skin. This is especially important when the natural regeneration capacity is insufficient. In addition, skin care products to protect against environmental influences, especially from the sun and wind, and delay the aging of the skin.

Medical topical compositions typically contain one or more drugs in effective concentration. For the sake of simplicity, reference is made to the clear distinction between cosmetic and medical use and corresponding products to the statutory provisions of the Federal Republic of Germany (eg Cosmetics Regulation, Food and Medicines Act).

Emulsions are generally understood to mean heterogeneous systems which consist of two liquids that are immiscible or only slightly miscible with one another, which are usually referred to as phases. In an emulsion, one of the two liquids is dispersed in the form of very fine droplets in the other liquid.

If the two liquids are water and oil and oil droplets are finely distributed in water, then it is an oil-in-water emulsion (O / W emulsion, eg milk). The basic character of a Q / W emulsion is characterized by the water. A water-in-oil emulsion (W / O emulsion, eg butter) is the reverse principle, with the basic character being determined by the oil.

Of course, a variety of ways are known in the art to formulate stable W / O preparations for cosmetic or dermatological use, for example in the form of creams and ointments spreadable in the range of room to skin temperature, or as lotions and milk, the are more fluid in this temperature range.

An object of the present invention was to provide preparations which can be formulated with a high or very high content of water-soluble and / or water-miscible substances without impairing the galenic quality or other properties of the preparations.

When <img file="EP0965331A2_D0001.tif" />High Internal Phase Emulsions "according to KJ Lissant: <i>The Geometry of High-Internal-Phase-Ratio Emulsions;</i> Journal of Colloid and Interface Science <b>22</b>, 462-468 (1966) defines emulsions having an internal phase of&gt; 70%. The production of stable, solid to semi-solid<img file="EP0965331A2_D0002.tif" /> High Internal Phase Water-in-Oil Emulsions ", especially those with a water content higher than 85% (<img file="EP0965331A2_D0003.tif" />Very High Internal Phase Water-in-Oil Emulsions ") and with nevertheless very good sensory properties, presents itself as an unsolved problem. Due to the very high water content of the emulsions <img file="EP0965331A2_D0004.tif" />"these break down on the skin particularly quickly - sensory unpleasant - in their main components (hydrophilic and lipophilic components) .Also, the lipophilic components separate into their individual components so that the lipids on the skin from each other - sensory unpleasant - <img file="EP0965331A2_D0005.tif" />abglitschen ".

The technique of varying the phase-to-volume ratio (ie, incorporating higher levels of liquid lipids) commonly used in water-in-oil emulsions may be due to the low lipid content <img file="EP0965331A2_D0006.tif" />High internal phase "-W / O emulsions only conditionally, at <img file="EP0965331A2_D0007.tif" />Very high internal phase "w / o emulsions) are not used at all

Surprisingly, it has been found that water-in-oil emulsions<ul id="ul0001" list-style="none" compact="compact"><li>(A) a content of water and optionally water-soluble substances of a total of at least 85 wt .-%, based on the total weight of the preparations and a content of lipids, emulsifiers and lipophilic constituents of a total of at most 15 wt .-%.</li><li>(b) containing at least one surfactant selected from the group of alkyl methicone copolyols and / or alkyl dimethicone copolyols,</li><li>(c) containing one or more lipid components comprising the lipid phase of the emulsion</li><li>(d) wherein the weight ratio of (b) to (c) is selected from the range 0.10 to 0.25,</li></ul> to remedy the disadvantages of the prior art.

Surprisingly, the formulations of the invention are extremely pleasant to use on the skin and are characterized by very high cosmetic elegance. It is with the means that are familiar to the expert without further inventive step achievable almost any viscosity, so that the present invention, for example, as a flowable dosage form (such as a lotion) or as a semi-solid to solid preparation (such as a cream) can be configured ,

An example of surface-active substances to be used particularly advantageously in the context of the present invention is the cetyl dimethicone copolyol sold by the company Th.Goldschmidt AG under the trade name ABIL® EM 90.

Furthermore, the emulsifier lauryl methicone copolyol which has been sold under the trade name Dow Corning® 5200 Formulation Aid by the company Dow Corning Ltd. has proved particularly advantageous. is available.

The total amount of the surface-active substances used according to the invention in the finished cosmetic or dermatological preparations is advantageously from the range from 0.075 to 7.5% by weight, preferably from 0.1 to 5.0% by weight, in particular from 1.0 to 3 , 0 wt .-% selected, based on the total weight of the preparations.

The preparations according to the invention particularly advantageously contain more than 88% by weight of water and optionally water-soluble substances, based on the total weight of the preparations.

Although it is known that it is possible with emulsifiers of the type described above to produce W / O emulsions with a high water content. Nevertheless, the known prior art could not point the way to the present invention.

In the context of the present disclosure is used as the upper term for fats, oils, waxes and the like occasionally the expression<img file="EP0965331A2_D0008.tif" />Lipids "used, as the expert is quite familiar <img file="EP0965331A2_D0009.tif" />Oil phase "and <img file="EP0965331A2_D0010.tif" />Lipid phase "used interchangeably.

Advantageously, the components of the lipid phase can be selected from the group of polar and nonpolar lipid components, for example selected from the group Vaseline (petrolatum), paraffin oil and polyolefins. Among the polyolefins, polydecenes and hydrogenated polyisobutenes are the preferred substances.

The oil phase may further contain substances according to the present invention advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms and from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms. Such ester oils can then be advantageously selected from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2 Octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, such as Jojoba oil.

Furthermore, the oil phase can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 carbon atoms. The fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semi-synthetic and natural oils, eg Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil, and the like.

Fat and / or wax components to be used advantageously in the oil phase according to the invention can be selected from the group of vegetable waxes, animal waxes, mineral waxes and petrochemical waxes. Favorable according to the invention are, for example, candelilla wax, carnauba wax, Japan wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, berry wax, ouricury wax, montan wax, jojoba wax, shea butter, beeswax, shellac wax, spermaceti, lanolin (wool wax), crepe fat, ceresin, ozokerite (earth wax). , Peraffinic waxes and microwaxes.

Further advantageous fat and / or wax components are chemically modified waxes and synthetic waxes, such as those known under the trade names Syncrowax HRC (glyceryl tribehenate), Syncrowax HGLC (C_16-36 Fatty acid triglyceride) and Syncrowax AW 1C (C_18-36 -Fatty acid) available from CRODA GmbH and montan ester waxes, Sasol waxes, hydrogenated jojoba waxes, synthetic or modified beeswaxes (eg dimethicone copolyol beeswax and / or C_30-50 Alkyl beeswax), polyalkylene waxes, polyethylene glycol waxes, but also chemically modified fats such. Hydrogenated vegetable oils (for example hydrogenated castor oil and / or hydrogenated coconut fat glycerides), triglycerides such as trihydroxystearin, fatty acids, fatty acid esters and glycol esters such as C_20-40Alkyl stearate, C_20-40-Alkylhydroxystearoylstearate and / or glycol montanate. Also advantageous are certain organosilicon compounds which have similar physical properties to the fatty and / or wax components mentioned, such as, for example, stearoxytrimethylsilane.

According to the invention, the fat and / or wax components can be present both individually and in a mixture.

Any mixtures of such oil and wax components are also advantageous to use in the context of the present invention. It may also be advantageous, if appropriate, to use waxes, for example cetyl palmitate, as the lipid component of the oil phase.

Of the hydrocarbons, paraffin oil, hydrogenated polyolefins (eg hydrogenated polyisobutene) squalane and squalene are to be used advantageously in the context of the present invention.

Advantageously, the oil phase may further comprise a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.

Advantageously, cyclomethicone (Octamethylcyclotetrasiloxan) can be used. However, other silicone oils are also advantageous for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Advantageously according to the invention, the oil phase may also comprise constituents selected from the group of classical fats, ie essentially triglycerides.

The oils according to the invention are preferably selected from the group of triglycerides of the following structure:<chemistry id="chem0001" num="0001"><img file="EP0965331A2_D0011.tif" /></chemistry> where R₁, R₂ and R₃ are independently selected from the group of branched and unbranched, alkylcarboxyl or alkenylcarboxyl groups having 12 to 24 carbon atoms. It may be advantageous if one or more aliphatic hydrogen atoms of the alkylcarboxyl or alkenylcarboxyl groups are substituted by hydroxyl groups.

In particular, it is advantageous if R₁, R₂ and / or R₃ Have 16 to 20 carbon atoms and are selected from the group of monosubstituted to triunsaturated carboxylic acid residues.

If R₁, R₂ and / or R₃ Wear hydroxyl groups, is the preferred alkenyl carboxyl radical of RicinolsÄureeste.

It is also particularly advantageous to choose oils from the group of soybean oil, sunflower oil, wheat germ oil and castor oil.

The aqueous phase of the preparations according to the invention may advantageously contain alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl - or - monoethyl ether and analogous products, furthermore low C-number alcohols, eg Ethanol, isopropanol, 1,2-propanediol, glycerol and in particular one or more thickeners, which or which can be advantageously selected from the group of silica, aluminum silicates, polysaccharides or their derivatives, eg Hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of the so-called Carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, or also the types ETD (<u>e</u>ASY-<u>t</u>O-<u>d</u>isperse) 2001, 2020, 2050, each individually or in any combination with each other.

A particular advantage of the present invention is that it permits the use of high concentrations of polyols, in particular glycerol.

Particularly advantageous preparations are also obtained when antioxidants are used as additives or active ingredients. According to the invention, the preparations advantageously contain one or more antioxidants. As favorable, but nevertheless optional to be used antioxidants all suitable or customary for cosmetic and / or dermatological applications or conventional antioxidants can be used.

Advantageously, the antioxidants are selected from the group consisting of amino acids (eg Glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg Urocaninsäure) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (eg Anserine), carotenoids, carotenes (eg α-carotene, β-carotene, Ψ-lycopene) and their derivatives, lipoic acid and derivatives thereof (eg Dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg Thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) as well as their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (eg Buthioninsulfoximine, Homocysteinsulfoximin, Buthioninsulfone, penta-, hexa-, Heptathioninsulfoximin) in very low tolerated dosages (eg pmol to μ mol / kg), furthermore (metal) chelators (eg α-hydroxy fatty acids, palmitic acid, phytic acid, lactoterrin), α-hydroxy acids (eg Citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg Ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg Vitamin E acetate), vitamin A and derivatives (vitamin A palmitate), as well as benzylic acid konyferyl benzoate, rutinic acid and derivatives thereof, ferulic acid and its derivatives, butylhydroxytoluene, butylated hydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and derivatives thereof , Zinc and its derivatives (eg Zno, ZnSO₄) Selenium and its derivatives (eg selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the inventively suitable derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances.

Particularly advantageous for the purposes of the present invention, oil-soluble antioxidants can be used.

An amazing feature of the present invention is that formulations of the present invention are very good vehicles for cosmetic or dermatological agents into the skin, with preferred agents being antioxidants which can protect the skin from oxidative stress. Preferred antioxidants are vitamin E and its derivatives as well as vitamin A and its derivatives.

The amount of antioxidants (one or more compounds) in the preparations is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 1 to 10% by weight, based on the total weight of the preparation ,

If vitamin E and / or its derivatives represent the antioxidant (s), it is advantageous to choose their respective concentrations from the range of 0.001-10% by weight, based on the total weight of the formulation.

If vitamin A or vitamin A derivatives, or carotenes or derivatives thereof, are the antioxidant (s), it is advantageous if their respective concentrations are within the range of 0.001-10% by weight, based on the total weight of the formulation, of to choose.

It is of course known to the person skilled in the art that cosmetic preparations are generally not conceivable without the usual hoof and additives. The cosmetic and dermatological preparations according to the invention can accordingly also contain cosmetic adjuvants, as commonly used in such preparations, for example, bodying agent, stabilizers, fillers, Preservatives, perfumes, Substances for preventing foaming, dyes, pigments have the coloring effect, Thickeners, surfactants, emulsifiers, softening, moisturizing and / or moisturizing substances, anti-inflammatory substances, additional active ingredients such as vitamins or proteins, Light stabilizers, insect repellents, bactericides, virucidal, Water, salts antimicrobial, proteolytic or keratolytic substances, Medicines or other common ingredients of a cosmetic or dermatological formulation such as alcohols, polyols polymers Foam stabilizers, organic solvents or electrolytes.

The latter can be selected, for example, from the group of salts with the following anions: chlorides, furthermore inorganic oxo element anions, of these in particular sulfates, carbonates, phosphates, borates and aluminates. Also on organic anions based electrolytes are advantageous, eg Lactates, acetates, benzoates, propionates, tartrates, citrates, amino acids, ethylenediaminetetraacetic acid and its salts and others. As cations of the salts are preferably ammonium, - alkylammonium, - alkali metal, alkaline earth metal, - magnesium, iron or Used zinc ions. There is no need to mention that in cosmetics only physiologically acceptable electrolytes should be used. Particularly preferred are potassium chloride, common salt, magnesium sulfate, zinc sulfate and mixtures thereof.

Mutatis mutandis have corresponding requirements for the formulation of medical preparations.

The W / O emulsions according to the invention can serve as a basis for cosmetic or dermatological formulations. These may be composed as usual and, for example, for the treatment and care of the skin and / or hair, as a lip care product, as a Deoprodukt and as make-up or Make-up removal product in decorative cosmetics or serve as a sunscreen preparation. For use, the cosmetic and dermatological preparations according to the invention are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics or dermatological agents.

Accordingly, cosmetic or topical dermatological compositions according to the present invention, depending on their structure, for example, be used as skin protection cream, cleansing milk, sunscreen lotion, nutrient cream, day cream or night cream, etc. It is possible and advantageous, the compositions of the invention as a basis for pharmaceutical To use formulations.

The low-viscosity cosmetic or dermatological compositions according to the invention can be present, for example, as preparations which can be sprayed from aerosol containers, squeeze bottles or by a pump device or in the form of a liquid composition which can be applied by means of roll-on devices, but also in the form of an emulsion which can be applied from normal bottles and containers.

Suitable propellants for sprayable from aerosol containers cosmetic or dermatological preparations in the context of the present invention, the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, compressed air is advantageous to use.

Of course, those skilled in the art will recognize that there are inherently nontoxic propellants which would be useful in the practice of the present invention in the form of aerosol preparations, but which should be avoided due to adverse environmental effects or other concomitant conditions, especially fluorocarbons and chlorofluorocarbons (US Pat. CFC).

Also favorable are those cosmetic and dermatological preparations which are in the form of a sunscreen. In addition to the active compound combinations according to the invention, these preferably additionally contain at least one UV-A filter substance and / or at least one UV-B filter substance and / or at least one inorganic pigment.

However, it is also advantageous in the context of the present inventions to prepare such cosmetic and dermatological preparations whose main purpose is not the protection from sunlight, but which nevertheless contain a content of UV protective substances. Thus, for example, UV-A or UV-B filter substances are usually incorporated in day creams.

Also, UV protectants, as well as antioxidants and, if desired, preservatives, provide effective protection of the preparations themselves against spoilage.

Advantageously, compositions of the invention may also contain substances that absorb UV radiation in the UVB range, the total amount of the filter substances, for example 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 10 wt .-%, in particular 1.0 to 6.0 wt .-%, based on the total weight of the preparations to cosmetic preparations for To provide the hair or protect the skin from the full range of ultraviolet radiation. They can also serve as a sunscreen for hair or skin.

If the emulsions according to the invention contain UVB filter substances, these may be oil-soluble or water-soluble. Oil-soluble UVB filters which are advantageous according to the invention are, for example:<ul id="ul0002" list-style="dash" compact="compact"><li>3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;</li><li>4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) -benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;</li><li>Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;</li><li>Esters of salicylic acid, preferably 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate,</li><li>Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;</li><li>Esters of benzalmalonic acid, preferably di (2-ethylhexyl) 4-methoxybenzalmalonate,</li><li>Derivatives of 1,3,5-triazine, preferably 2,4,6-trianilino (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine.</li></ul>

The list of said UVB filters which can be used in combination with the active compound combinations according to the invention should of course not be limiting.

It may also be advantageous to formulate lipodispersions according to the invention with UVA filters which have hitherto usually been present in cosmetic preparations. These substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl-3- (4 '-isopropylphenyl) propane-1,3-dione.

Cosmetic and dermatological preparations according to the invention may also contain inorganic pigments which are commonly used in cosmetics for protecting the skin from UV rays. These are oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, as well as modifications in which the oxides are the active agents. Particular preference is given to pigments based on titanium dioxide.

As further constituents can be used:<ul id="ul0003" list-style="dash" compact="compact"><li>Furs, waxes and other natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, eg with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with lower C-number alkanoic acids or with fatty acids;</li><li>Alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, - monoethyl or monobutyl ether, diethylene glycol monomethyl or - monoethyl ether and analogous products.</li></ul>

Compositions according to the invention may also contain active substances (one or more compounds) which are selected from the group: acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, for example hydrocortisone-17-valerate, vitamins, for example ascorbic acid and derivatives thereof, vitamins of the and D series, vitamin B very favorable₁, the vitamin B₁₂ the vitamin D.₁, but also bisabolol, unsaturated fatty acids, namely the essential fatty acids (often called vitamin F), in particular γ-linolenic acid, oleic acid, eicosapentaenoic acid, docosahexaenoic acid and its derivatives, chloramphenicol, caffeine, prostaglandins, thymol, camphor, extracts or other herbal products and animal origin, eg Evening primrose oil, borage oil or currant seed oil, fish oils, cod liver oil but also ceramides and ceramide-like compounds and so on. It is also advantageous to choose the active ingredients from the group of lipid-replaceable substances, for example Purcellinöl, Eucerit® and Neocerit®.

The amount of such active ingredients (one or more compounds) in the preparations according to the invention is preferably 0.001 to 30 wt .-%, particularly preferably 0.05 to 20 wt .-%, in particular 1-10 wt .-%, based on the Total weight of the preparation.

The following examples are intended to illustrate the present invention without limiting it. The numerical values ​​in the examples are percentages by weight, based on the total weight of the respective preparations.<tables id="tabl0001" num="0001"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 1 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">cetyl dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">Caprylic / capric</entry><entry namest="col2" nameend="col2" align="char" char=",">4.00</entry></row><row><entry namest="col1" nameend="col1" align="left">dicaprylyl</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">octyldodecanol</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.0</entry></row></tbody></tgroup></table></tables><tables id="tabl0002" num="0002"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 2 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">lauryl</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">octyldodecanol</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">C_12-15alkyl benzoates</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">squalane</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum liquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">6.00</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">sodium chloride</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0003" num="0003"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 3 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">cetyl dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">squalane</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum liquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">stearyl</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">Hydrogenated polysiobutene</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0004" num="0004"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 4 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">lauryl</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum liquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">9.00</entry></row><row><entry namest="col1" nameend="col1" align="left">tocopherol</entry><entry namest="col2" nameend="col2" align="char" char=",">0.50</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">panthenol</entry><entry namest="col2" nameend="col2" align="char" char=",">0.30</entry></row><row><entry namest="col1" nameend="col1" align="left">1,3-butylene glycol</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">serine</entry><entry namest="col2" nameend="col2" align="char" char=",">0.30</entry></row><row><entry namest="col1" nameend="col1" align="left">biotin</entry><entry namest="col2" nameend="col2" align="char" char=",">0.10</entry></row><row><entry namest="col1" nameend="col1" align="left">Distärkehosphat</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0005" num="0005"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 5 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Cetyldimethiconecopolyol</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Isohexadecan</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum liquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0</entry></row><row><entry namest="col1" nameend="col1" align="left">4- (tert-butyl) -4'-methoxydibenzoylmethane</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Octyl Methoxycinnamate</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0</entry></row><row><entry namest="col1" nameend="col1" align="left">4-methyl-benzylidenecamphor</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5</entry></row><row><entry namest="col1" nameend="col1" align="left">Tris [anilino (p-carbo-2'-ethyl-1'-hexyloxy)] - triazin</entry><entry namest="col2" nameend="col2" align="char" char=",">0.5</entry></row><row><entry namest="col1" nameend="col1" align="left">Titanium dioxide</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0</entry></row><row><entry namest="col1" nameend="col1" align="left">zinc oxide</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0006" num="0006"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 6 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">lauryl</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">Isohexadecan</entry><entry namest="col2" nameend="col2" align="char" char=",">4.50</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum subliquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">4.50</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">sodium chloride</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0007" num="0007"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 7 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Cetyldimethiconecopolyol</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">Caprylic / capric</entry><entry namest="col2" nameend="col2" align="char" char=",">4.00</entry></row><row><entry namest="col1" nameend="col1" align="left">dicaprylyl</entry><entry namest="col2" nameend="col2" align="char" char=",">2.50</entry></row><row><entry namest="col1" nameend="col1" align="left">octyldodecanol</entry><entry namest="col2" nameend="col2" align="char" char=",">2.50</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">30.00</entry></row><row><entry namest="col1" nameend="col1" align="left">propyleneglycol</entry><entry namest="col2" nameend="col2" align="char" char=",">5.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0008" num="0008"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 8 (W / S Cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">lauryl</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">cyclomethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">9.00</entry></row><row><entry namest="col1" nameend="col1" align="left">sorbitol</entry><entry namest="col2" nameend="col2" align="char" char=",">15.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0009" num="0009"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 9 (W / S cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">cetyl dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">cyclomethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">7.00</entry></row><row><entry namest="col1" nameend="col1" align="left">dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">5.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0010" num="0010"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 10 (W / O cream):</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">lauryl</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0</entry></row><row><entry namest="col1" nameend="col1" align="left">cetyl dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Sunflower seed oil</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0</entry></row><row><entry namest="col1" nameend="col1" align="left">dicaprylyl</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum liquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">4.0</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0</entry></row><row><entry namest="col1" nameend="col1" align="left">sodium chloride</entry><entry namest="col2" nameend="col2" align="char" char=",">0.7</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0011" num="0011"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 11 (W / O Cream)</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">cetyl dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">Caprylic / capric</entry><entry namest="col2" nameend="col2" align="char" char=",">4.00</entry></row><row><entry namest="col1" nameend="col1" align="left">jojoba oil</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">Dimethiconol</entry><entry namest="col2" nameend="col2" align="char" char=",">0.10</entry></row><row><entry namest="col1" nameend="col1" align="left">cyclomethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">dimethicone copolyol</entry><entry namest="col2" nameend="col2" align="char" char=",">0.20</entry></row><row><entry namest="col1" nameend="col1" align="left">distarch</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.00</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.70</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables><tables id="tabl0012" num="0012"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row rowsep="1"><entry namest="col1" nameend="col2" align="left"><b>Example 12 (emulsion make-up)</b></entry></row><row rowsep="1"><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center">Wt .-%</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">cetyl dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">octyldodecanol</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">C_12-15alkyl benzoates</entry><entry namest="col2" nameend="col2" align="char" char=",">2.00</entry></row><row><entry namest="col1" nameend="col1" align="left">squalane</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">Paraffinum liquidum</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">distarch</entry><entry namest="col2" nameend="col2" align="char" char=",">0.50</entry></row><row><entry namest="col1" nameend="col1" align="left">dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">0.50</entry></row><row><entry namest="col1" nameend="col1" align="left">glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">1.50</entry></row><row><entry namest="col1" nameend="col1" align="left">magnesium silicate</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">mica</entry><entry namest="col2" nameend="col2" align="char" char=",">0.50</entry></row><row><entry namest="col1" nameend="col1" align="left">iron oxides</entry><entry namest="col2" nameend="col2" align="char" char=",">0.50</entry></row><row><entry namest="col1" nameend="col1" align="left">Titanium dioxide</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">talc</entry><entry namest="col2" nameend="col2" align="char" char=",">1.00</entry></row><row><entry namest="col1" nameend="col1" align="left">tapioca</entry><entry namest="col2" nameend="col2" align="char" char=",">0.25</entry></row><row><entry namest="col1" nameend="col1" align="left">Perfume, preservatives, dyes, antioxidants</entry><entry namest="col2" nameend="col2" align="char" char=",">qs</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">ad 100.00</entry></row></tbody></tgroup></table></tables>