Co-extruded medical balloons and catheter using such balloons

Background of the Invention

0001The present invention relates to balloons for medical devices and medical devices utilizing such balloons. More particularly, the present invention relates to medical or surgical balloons and catheters using such balloons, particularly those designed for angioplasty, valvuloplasty and urological uses and the like. The balloons of the present invention can be tailored to have expansion properties which are desired for a particular use and can be inflated to a predetermined diameter and still be resistant to the formation of pin holes and leakage.

Description of the Prior Art

0002In the past, polyethylene, polyethylene terapthalate and polyamide balloons have been used with medical catheters. Polyethylene balloons are particularly advantageous because they can be heat bonded to a like-material substrate and have a relatively low tip diameter, that is the profile of the tip at the connecting joint between the balloon and the catheter can be fairly small. Also, the polyethylene balloons are soft so that they can pass through blood vessels without trauma. Moreover, polyethylene balloons are resistant to the propagation of pin holes, primarily because the walls are thick. But since they are thick, they are large and pass by tight lesions only with great difficulty.

0003Balloons of polyethylene terapthalate provide low deflated profiles and can have thin walls because such materials have high tensile strengths and adequate burst strength. On the other hand, polyethylene terapthalate balloons require adhesives to bond them to the catheters and adhesive bonding frequently is not dependable and it thickens the catheter at the point of the bond. Moreover, polyethylene terapthalate can have poor pin hole resistance largely due to the very thin walls.

0004<patcit id="pcit0001" dnum="EP0420488A"><text>European patent publication no. 0420488</text></patcit> describes a method of producing laminated inflatable, substantially inextensible expander members having composite properties for use on intravascular catheters, such as angioplasty catheters. Diverse polymeric compounds of differing properties are co-extruded to create a multilayer parison. The parison is subsequently drawn and expanded in a blow moulding operation to yield an expander member exhibiting properties including lubricity, burst strength, limited radial expansion, bondability and rupture characteristics.

<u>Summary of the Invention</u>

0005It has been discovered that the drawbacks of the polyethylene and the polyethylene teraphalate balloons of the prior art can be remedied through the use of laminated balloon constructions which comprise a tubular body formed of a plurality of co-extruded and coextensive layers of different polymeric materials.

0006According to a first aspect of the invention, there is provided a catheter for medical purposes according to the characterising clause of Claim 1.

0007According to a second aspect of the invention, there is provided a method of manufacturing a medical catheter according to Claim 15.

0008In preferred embodiments of the invention the catheter utilises a multi-layered balloon which combines the advantages of both materials in a balloon, but does not have the disadvantages of either. The balloon includes a layer of a relatively thick, biaxially orientated ethylenic polymeric material such as polyesters, polycarbonates, polyethylene teraphalate and their copolymers, or polyamides such as Nylon^™. These materials constitute a base structural layer (or layers) and give the balloon its tensile strength and provide for "wear" resistance. The base structural layer may have a thickness between about 5 and 2.5 × 10^-6 m (0.2 and 1.0 mil) or higher. A second layer is co-extruded with the base structural layer and is coextensive therewith. The second layer preferably is a polyolefin such as polyethylene and copolymers thereof and can be heat-bonded to a catheter, that is adhesives need not be used. The heat bondable second layer can be disposed on one and preferably both sides of the base structural layer.

0009The base structural layer again is a material that does not itself readily thermally bond to a polyethylene catheter tubing. In one option, not part of this invention, sleeves of mutually bondable materials are slipped over the joints between the catheter and the balloon and the sleeves are heated to join the balloon to the sleeve and simultaneously join the sleeve to the catheter whereby to act as a fluid-tight seal between the catheter and the balloon.

0010With regard to multilayered balloons, the second layer (or layers) which is disposed on the base structural layer and co-extruded therewith can also serve as a barrier between the base structural layer and the environment. For example, when a polyamide such as Nylon is used as the base structural layer, a thin layer of maleic anhydride-modified ethylenic polymers such as Plexar^™ can also be co-extruded with it. When layers are disposed on both sides of the base structural layer they keep moisture from effecting the Nylon's properties. Additional layers sometimes may also be co-extruded to bind and tie dissimilar layers together in the co-extrusion operation. When Nylon is used, for example, no tying layers are necessary between it and the heat bondable layer. In other cases, however, as when polyester or polycarbonate polymers are used as the base structural layer, adhesion enhancement may be necessary. Such adhesive enhancement may take the form of ultraviolet light irradiation of the product or the Incorporation of a co-extruded tying adhesive layer.

0011With regard to the use of a multilayered sleeve to Join the balloon to the catheter, any conventional medical balloon material can be used that does not bond to the catheter without adhesives. The multilayered sleeve can be formed of a base layer of the same material as the balloon with a polyethylene layer disposed on at least the inner side of the sleeve. The polyethylene will adhere to both the catheter and the balloon and form a joint with heat treatment alone.

0012The balloons have advantages of both the polyethylene and the materials of the base structural layer. When polyethylene terapthalate is the base, very thin walls can be used with high burst strength. For example, when a typical 3.0 x 10^-3m (mm) diameter maleic anhydride-modified ethylenic polymer is coated on a Nylon base structural layer thy resulting balloon can have a wall thickness of 12.7 × 10^-6 m (0.5 mil) and a low deflated profile which is comparable with polyethylene terapthalate balloons and is much lower than polyethylene balloons. When using Nylon, the material that is used is biaxially orientable and has higher tensile strength than polyethylene material, thereby resulting in a much thinner wall for comparative burst strength.

0013It has been found that pin hole resistance of the construction is comparable to polyethylene and substantially superior to polyethylene terapthalate. A balloon co-extruded with Selar has superior abrasion resistance and pin hole resistance then polyethylene terapthalate balloons. Polyamide material is superior to polyethylene terapthalate and polyethylene materials in pin hole resistance. The balloon itself is soft for non-traumatic passage through blood vessels and is comparable to polyethylene because polyamide is not as stiff as polyethylene terapthalate.

0014In a specific embodiment of a multilayered extruded balloon, it has been found that the use of the above mentioned Selar PT resin, a trademarked compound (preferably available as selar PT 4368 from E.I. Dupont de Nemaurs Co. of Wilmington, Delaware) as a layer disposed on the base structural layer (or blended with polyethylene terapthalate) will make the balloon more resistant to abrasion and provide it with a softer feel. Selar co-extrusion in multi-layered balloons diminishes pin hole formation and will minimize failure when working with calcified lesions. Moreover, the Selar may be used as the inner layer of the balloon for use with procedures which include internal electrodes or radiopaque markers which could puncture it.

Brief Description of the Drawings

0015<ul id="ul0001" list-style="none" compact="compact"><li><figref idref="f0001">Figure 1</figref> is a side elevational view of a catheter with a multi-layered balloon. The balloon is shown in the distended condition;</li><li><figref idref="f0001">Figure 2</figref> is a view of the same catheter in the folded condition;</li><li><figref idref="f0001">Figure 3</figref> is a cross-sectional view of the balloon of the present invention taken along the line 3-3 of <figref idref="f0001">Figure 1</figref> showing the polymeric layers in the balloon;</li><li><figref idref="f0001">Figure 4</figref> is a cross-sectional view taken along the line 4-4 of <figref idref="f0001">Figure 2</figref> showing the balloon in its folded condition.</li><li><figref idref="f0001">Figure 5</figref> is a cross sectional view of a distended balloon disposed at the end of a catheter and joined to the catheter by a sleeve, which is not part of this invention.</li></ul>

Description of the Preferred Embodiments

0016An illustrative catheter 1 is shown in <figref idref="f0001">Figures 1 and 2</figref>. Catheter 1 includes a catheter tube 3 having a proximal end 5, a distal end 6 and a tip 7. A distended co-extruded medical balloon 8 is shown in <figref idref="f0001">Figure 1</figref> secured to the outside of the distal end 6 and the tip 7, the co-extrusion being critical to the present invention. The interior of the balloon 8 is in communication with at least one lumen (not shown in this Figure) of the catheter tube 3. To form the tip 7 (and the portion of the catheter between the distal end 6 and the tip 7 to support the balloon 8) a portion of the catheter tube 3 is cut away so that only the lumen that houses an internal guide wire 14 remains (as shown in dotted lines within the balloon 8) .

0017Extending through the interior of the tube 3 are a plurality of lumens (shown in <figref idref="f0001">Figures 3 and 4</figref>) which can serve a variety of functions, for example, housing the guide wire 14, inserting materials into the blood stream or inflating or deflating the balloon. Except for the balloon 8, all of the various components perform functions which are generally appreciated and known in the art.

0018To use, the catheter 1 (as shown in <figref idref="f0001">Figure 2</figref>) is inserted into the cardiovascular system until the co-extruded balloon 8 is located at the site of an occlusion. At this stage, the balloon 8 is typically folded and collapsed and has an external diameter, less than the inflated diameter, as can be seen by a comparison of <figref idref="f0001">Figures 1 and 2</figref>. Once the balloon 8 is maneuvered to the location of the occlusion, a pressurizing fluid is inserted at the proximal end 5 of the catheter tube 3 for inflation of the balloon 8. The fluid unfolds the balloon 8 until it presents a relatively smooth expanded profile for imparting forces that are radially outwardly directed at the desired site within the body in order to achieve the desired result of lesion dilation, restriction reduction or similar treatment.

0019Inserting the catheter 1 in an artery requires that the tube 3 be of a semi-flexible material. Tube 3 preferably is composed of a polyolefin copolymer, for example a conventional high density polyethylene. The diameter of the tubing is between about 12 and 16 French and may be coated on the inside and outside surfaces with, for example, a silicone based material to promote slippage in an aqueous environment.

0020As seen in <figref idref="f0001">Figures 3 and 4</figref>, the co-extruded balloon 8 results in a laminated construction. The laminates of the construction include a main structural layer 8B which is generally between about 5 and 63.5 × 10^-6 m (0.2 and 2.5 mil) or thicker, and formed of one or more biaxially oriented polymers such as polyamides, polyesters, polycarbonates and their copolymers. Co-extruded with and bonded to the structural layer 8B is an inner layer 8C of heat bondable polyolefin such as Plexar. Plexar is an anhydride-modified polyethylene and a trademarked product sold by Quantum Chemical Corporation of Cincinnati, Ohio. The heat bondable layer 8C is attached directly to the distal end 6 of catheter tube 3 and is secured to the balloon 8 by a heat seal joint 11. A similar joint 11 is formed between the balloon 8 and the catheter tip 7.

0021The heat bondable layer 8C is co-extruded with the structural layer 8B and has a thickness of between about 12.7 and 25 × 10^-6 m (0.5 and 1.0 mil). Preferably, two heat bondable layers are co-extruded with the structural layer 8B. The inner layer 8B serves as a mechanism to provide a heat seal joint 10 between the distal and 6 of the catheter tube 3 and the structural layer 8B of the balloon 8. When two layers are co-extruded with the structural layer 8B, the inner layer 8C forms the heat bondable layer and the outer layer 8A forms a projective sheath for the main structural layer 88. When polyamides such as Nylon are used as the structural layer 8B, Plexar can be used as the heat bonding layer 8C. The outer layer 8A can be formed of the same material and provide for softness for non-traumatic passing through vessels and good pin hole resistance.

0022An alternative to the construction shown in <figref idref="f0001">Figure 1</figref>, another construction not part of the invention is to dispose a balloon formed of a base structural layer 8B of polyethylene terapthalate and an outer layer 8A of polyethylene around the distal end 6 of the catheter tube 3 and then place a sleeve 20 formed of heat bonding layer 20C of high density polyethylene on a base layer 208 of Nylon over the end of the balloon 8 whereby the polyethylene of the balloon seals to the polyethylene of the sleeve and the Nylon seals to the catheter 3. In cases where additional strength is needed, an innermost layer can be formed of high density polyethylene and an outermost layer is formed of Nylon with Plexar sandwiched therebetween.

0023It has been found that where strength, abrasion resistance and/or "feel" are important in medical balloons that a oo-extrusion which includes Selar resin can be used to provide for these characteristics. The Selar can be used by itself as the inner and/or outer layer or it can be blended with polythylene terapthlate. Tests of a 41 × 10^-6 m (1.6 mil) thick balloon with a Selar outer layer (a 50/50 blend of Selar and polyethylene terapthalate) were conducted by rubbing a balloon inflated to 6.078 × 10⁵ Nm^-2 (6 atm) and rubbing it back and forth over medium grade emery cloth until failure. The balloons with Selar of 50/50 blend layers exceeded 200 cycles while a 46 × 10^-6 m (1.8 mil) thick polyethylene terapthlate balloon failed in 87 cycles. Selar is a toughened grade of polyethylene terapthalate and it can be co-extruded with the base structural layers herein disclosed according to known techniques.

0024Referring to <figref idref="f0001">Figures 3 and 4</figref>, the interior of the co-extruded balloon 8 is shown in cross section. In <figref idref="f0001">Figure 3</figref>, the balloon is shown in its distended or inflated condition whereas in <figref idref="f0001">Figure 4</figref> the balloon is shown in its deflated or folded condition. The balloon 8 can typically have an outer diameter that can be of the order of roughly three to six and even more times the outer diameter of the catheter tube 3. Pressurised fluids used to inflate the balloon include those conventionally used In the art, such as the well known aqueous solutions if they do not pose a problem of leaving residual fluids or chemically reacting with the balloon. Such fluids are introduced into the balloon 8 and removed therefrom through a lumen L¹ which is in fluid flow relationship with the interior thereof. Venting of gasses initially trapped in* the catheter and the balloon prior to introduction of the inflation fluids is accomplished by expelling them through a second lumen L² also formed in the interior of the catheter tube 3. Preferably, lumen L¹ and L² are cut off at joint 10 so as to leave only a third lumen L³.

0025The third lumen L³ houses a guide wire 14 that passes through the balloon 8 and the tip 7. The third lumen L³ is different from the other two lumens, L¹ and L², in that it extends entirely through the balloon 8 from the distal end 6 to the tip 7 so as to sheath the guide wire. In some embodiments, it may be desirable to combine the functions of lumens, L¹ and L², to only have a single lumen for inflating or deflating the balloon. Lastly, the lumen defined by L³ provides for a housing for a guide wide 14 which is removably housed in it. Guide wire 14 passes through the entire length of the catheter 3 and through the balloon 8 (while preferably sheathed in lumen L³) and thence into an axial bore (not shown) in tip 7 to emerge from the end of tip 7 (as shown in <figref idref="f0001">Figures 2 and 3</figref>).

0026Each of the lumens L¹, L² and L³ is formed by walls 15 and 16 that are extruded as the catheter tube is extruded from an extrusion machine, as is well known in the art. The thickness of the walls 15 and 16 can be between 12.7 and 254 × 10^-6 m (0.5 and 10 mil), as is well known.

0027As shown in <figref idref="f0001">Figure 4</figref>, the diameter of the folded balloon 8 is substantially the same or less than the diameter of the catheter tube 3 so as to provide for easy passage of the catheter through blood vessels. The extruded tubing 3 has a nominal wall thickness that generally is of the order of six to twelve times the desired wall thickness of the balloon 8.

0028To form the co-extruded ballons, the materials initially are melted separately in extrusion machines. When melted, the materials are separately forced into an extrusion head and extruded so that they are forced out as a plurality of layers in the form of a single tube which critically forms the ballon of the present invention. A Nylon-Plexar or polyehtylene-polyethylene terapthalate ballon may be formed by taking a 152.4 x 10^-3m (six inch) length of the three layered tubing which is to be manufactured into a ballon and placing it in a holding fixture. The left hand end of the tube is attached to a Touhy Borst adapter. The right hand end of the tube is heat sealed to temporarily prevent pressurised air from escaping. The right hand end is attached to a tension line which is pulled for the force of at least 1.47N (150 grams) (for a 3.0 x 10 ^-3m (mm) diameter balloon). The tubing is heated under a pressure of between about 6.895 x 10⁵ Nm^-2 (100 psi) and 27.58 x 10⁵ Nm^-2 (400 psi) to about 99°C (210°F) for several seconds. Afterwards, the heated area is cooled and the support frame is spread apart slightly so as to expose a pre-determined section of tubing to permit the balloon area to be reheated to a temperature between about 99°C (210°F) and 104°C (220°F) to permit the balloon to be expanded to a desired diameter under pressure for about 35 seconds. The pressure is then stopped and the deflectors are slid to the ends of the balloon and the balloon is heated for a third time to about 154°C (310°F) to heat set the balloon and biaxially orient the polymeric matrix. This third heating prevents the balloon layers from flaking and prevents the balloon from expanding beyond the size at which it will set during the heat setting period. The heat setting takes about 8 seconds.

0029For a Nylon-Plexar balloon, the deflectors from the tubes are then removed and another unheated tube is mounted in the fixture. The catheter tube is slide inside the balloon so that it engages the heat bondable polyethylene layer. The balloon is bonded to the polyethylene shaft by heat bonding in a temperature of about 154°C (310°F) which is long enough to melt the polyethylene end and the inner layer of the polyethylene together.

0030It is quite important to recognise that the heat treatment steps as described herein essentially prevent the delamination of the heat bondable layers 8C and 8A from the main structural layer 8B as is required when a laminated construction is used as a catheter. Flaking and delamination is not a problem, however, with polyethylene terapthalate and Selar layers.

0031While it is apparent that modifications and changes may be made within the scope of the present invention, it is intended, however, only to be limited by the scope of the appended claims.