Intra-sorption agent.

0001The invention relates to an intra-sorbent according to the preamble of the first claim.

0002An intra-sorbent or carrier material is used to introduce and fix substances in a matrix in such a way that they are not released into the substrate.

0003The term intra-sorption is a new word creation and describes a sorption process in which a substance within a matrix is ​​selectively absorbed by another substance connected to it.

0004A new path is being followed, in which a certain material, for example a color, can have an intimate connection with a substrate, such as skin, nails, leather or panels made of wood or plastic, and is not sorbed in or on this substrate or spreads through it.

0005Absorption through the skin or other permeable substrates of active ingredients from preparations that are used for beautification, care or treatment often poses a problem. Epidermal absorption leads to discoloration of the skin and possibly to toxic side effects.

0006The absorption of strongly smelling substances, such as mercaptans, leads to the permanent release of malodorous substances from the skin. The skin absorption of many other substances can lead to discoloration, itching, burning, then to allergic reactions, then to mutagenic, teratogenic and carcinogenic symptoms.

0007With other substrates such as hair or nails, leather and other permeable materials, undesirable absorption can result in swelling, cracking, peeling, splitting, staining, clouding, structural damage, discoloration and more.

0008Known agents of this type are used, for example, cosmetically to apply substances that color the skin. These so-called tanning agents are basically divided into two groups, from which the first group<ul id="ul0001" list-style="none"><li>a) There are agents that are easy to remove by water, while the second group consists of</li><li>b) means exist that cannot be removed by water.</li></ul>

0009The agents belonging to group a) have the disadvantage that they can be removed by light contact with water and, for example, when sweating or swimming. Therefore, they can only be used for cosmetic purposes to a limited extent, because they have to be constantly monitored and added, for example, for a festive occasion.

0010Category a) includes, for example, tanning creams that temporarily impart tanned skin to the wearer.

0011Group b) includes agents which are described, for example, in DE-OS 16 17 431. This product cannot be removed by water and has the purpose, for example, of protecting dentists' frequently washed hands.

0012EP-PS 0 197 485 describes another agent which is resistant to water contact, such as when sweating, swimming and washing.

0013However, it is usually desirable to remove an agent applied to the skin when it is no longer needed. This can be the case after a festive occasion or a trip, for example, and is important because coating the skin can have long-term side effects. The DE-OS gives no information on how to relentlessly remove the product. However, it should be mentioned that water-free, so-called removal agents may can be harmful to the skin.

0014The object of the invention is therefore to create an agent which does not have the disadvantages of previous embodiments.

0015The means to be created should be provided with a matrix that<ul id="ul0002" list-style="dash"><li>is odorless, transparent and not greasy,</li><li>does not adhere to the surface of the skin or bind to it,</li><li>is not ascertainable or noticeable, and cannot be removed by rubbing, and</li><li>does not form a visible border.</li></ul>

0016Furthermore, the agent should also be applicable to other substrates such as hair, nails, wood and plastic.

0017According to the invention, this object is achieved by the features in the characterizing part of the first claim.

0018Embodiments are described in the dependent claims.

0019The design created is thus water-resistant, but it does not require any skin-damaging agents for removal, because surfactants are sufficient.

0020It has now been found that, for example, tanning of the skin can be simulated by applying to the skin or another permeable substrate a carrier material in which the active substances are retained by intra-sorption, as described below.

0021Intra-sorption occurs because the active substance is enclosed in a co-sorption substance and lies on the substrate, but does not come into direct contact with it. The carrier material on the other hand attaches to various hydrophilic, lipophilic, proteophilic or other constituents of permeable substrates, such as skin, hair, nails, leather or certain artificial materials.

0022Active substances fixed in this way, when applied to the skin or another substrate, behave as if they were a component of the same, even if they are neither bound directly to the substrate nor absorbed by it. This is because the active substances in the matrix, formed by the carrier material, are “trapped” and are only connected to the substrate by the matrix itself.

0023It was also found that certain modifiers, such as dispersants, can further reduce possible absorption because they are apparently able to retain the active substances in the matrix.

0024While the active ingredients embedded in the matrix are not removed by influences such as rubbing, sweating or contact with water, they are easily removed by the action of surface-active substances such as soap and detergents. In this regard, there is behavior that differs from substantivity, which consists in that an applied material adheres firmly to the application site and can therefore hardly be removed.

0025The necessary properties and components of the intra-sorbent include:<ul id="ul0003" list-style="none"><li>a) Active substances that have the desired effect</li><li>b) Non-volatile or non-volatile components</li><li>c) modifiers</li><li>d) Volatile Shares</li></ul><ul id="ul0004" list-style="none"><li>a) Active ingredients are active ingredients that can be embedded in intra-sorbents, they include a wide range of substances that are soluble and non-soluble in an aqueous and non-aqueous environment and that have cosmetic, cleaning, nourishing, protective, medical or other effects.</li><li>b) Non-volatile or non-volatile components form a matrix for the active substances which have an affinity for the substrate. The non-volatile or low-volatility components, alone or in combination with modifiers, enclose the active substances and prevent the possibility of absorption by the substrate, the penetration of the active ingredients into the substrate being made difficult anyway due to the affinity of the non-volatile or low-volatility components for the substrate. In order to ensure increased consumer acceptance and usefulness, the non-volatile or low-volatility components alone or together with the modifier as such no longer have to be perceptible in a short time or only to an extent acceptable to the consumer.</li><li>c) The modifiers can also perform useful and valuable functions. For example, it has been found that modifying agents, such as certain detergents, can increase the embedding of the "active substances" in the non-volatile matrix, as a result of which the release and thus the absorption by the substrate is additionally reduced. Modifiers can also be used to change the properties of the active substances and the non-volatile or volatile additives.</li><li>d) The volatile components are required both for aesthetic reasons in order to facilitate the application of the intra-sorption material to the substrate, and also to ensure sufficient covering power and satisfactory adhesion of the material to the substrate after their evaporation. The volatile component can have other useful effects, such as preparing the substrate surface for the absorption of the intra-sorbent, it can also cause antimicrobial or similar properties, heat and cold sensations on the skin, as well as other useful properties.</li></ul>

Examples of components

A) Active substances

0026The active ingredients encompass a wide range of aqueous and non-aqueous, soluble and insoluble constituents which produce beautifying, cosmetic, cleaning, treating, protecting, medical or other effects, with the property that they are hardly affected by the substrate to which they are applied be absorbed, proves to be an advantage.

0027These include:<ul id="ul0005" list-style="none"><li>a1) gloss-producing or gloss-reducing substances</li><li>b1) Oil and moisture absorbing agents</li><li>c1) Materials to reduce loss of moisture, oils and other volatile or washable substances</li><li>d1) Substances for repelling, embedding, dispersing or dividing water, water vapor, dirt, gases, microbes and viruses or other undesirable materials.</li><li>e1) Dyes, pigments, iridescent pigments, liquid crystals, organic dyes (eg melanin), as well as substances that develop or reinforce dyes, are approved for food, pharmaceuticals and cosmetics, as well as industrially required.</li><li>f1) Heat, radiation or other energy-absorbing, protective, dispersing or repelling materials as well as antioxidant, anti-reducing, anticorrosive and other substances protecting against exogenous or endogenous attacks.</li><li>g1) softening and firming agents</li><li>h1) fragrances and other smelling materials</li><li>i1) Also substances for absorption, changes or prolongation of action of fragrant or smelly compounds.</li><li>j1) Cosmetic, well-being or medical active ingredients, insecticides, such as peliculocides etc., in which one or more effects are favorably influenced if their absorption by the skin, hair, nails, membranes or other substrates is prevented or reduced or if this creates an unexpected or new effect.</li><li>k1) Polishing, as well as other materials that improve or restore the surface, reduce wear, and other materials.</li></ul>

0028It may often be desirable, although this is not a necessary requirement, that the active substances have a low solubility in the non-volatile or low-volatility component.

B) Non-volatile or non-volatile components

0029These form a matrix for the "active" components. They should have a certain affinity for the substrate. The non-volatile or non-volatile component, alone or in combination with modifiers, hold the active substances and prevent the possibility of absorption by the substrate. At the same time, however, the affinity of the non-volatile or low-volatility component for the substrate also causes the "trapped" active substances to be retained.

0030It may often be desirable, although this is not a necessary requirement for the active substance to have a certain solubility in the non-volatile or low-volatility component. In order for increased acceptance by the user and an increased benefit to be achieved, the non-volatile or low-volatility component by itself or together with the modifiers on the substrate no longer has to be ascertainable or can no longer be perceived by the user or can only be perceived to an acceptable extent be.

0031One or more quantifiable tests must be able to demonstrate whether the non-volatile or non-volatile components meet these requirements. For example, tests have been developed to determine visibility, stickiness, greasiness, surface change and other properties. These test methods make it easier to find materials which, after application to a substrate, can practically no longer be perceived by the user in a very short time, or only to an acceptable extent.

0032Examples of such components include:<ul id="ul0006" list-style="none"><li>a2) Naturally occurring lipids of human, animal or maritime origin, then also those that come from insects, microbes, fungi, viruses or other reproductive beings. Examples are: ceramides, sphinogolipids, wax and sterol esters, then lipids which have been removed from the intercellular space, the ganglia and membranes. Then these related lipids and their natural or derived forms or derivatives by bio-technology or synthesis.</li><li>b2) Natural lipids, waxes and other semi-solid compounds obtained by bio or genetic engineering, which were originally synthetically produced or are of human, animal, maritime and vegetable origin or come from insects, microbes, fungi, viruses or other reproductive sources, as well as their derivatives.</li><li>c2) Lipids of synthetic origin, waxes such as polyethylene waxes or hydrogenated jojoba oil and other materials of synthetic origin or those which are synthetic variants or descendants of substances which are reproducible by humans, animals, sea creatures, plants, insects, microbes, fungi, viruses or other Substances originate.</li><li>d2) Higher petroleum factors, other hydrocarbons and their derivatives, such as waxes and petroleum jelly with a reduced content of liquid, paraffin oil-like components.</li><li>e2) Pure and modified silicones and those to which crosslinking and functional groups are attached, as long as they meet the requirements mentioned above.</li></ul>

C) Volatile components

0033The volatile components are used to make it easier to apply the system to the substrate (eg by reducing the viscosity, by increasing the spreading capacity) in order to create sensual impressions such as smells, cold, heat; then, so that even evaporation and sufficient adhesion to the substrate is achieved after evaporation.

0034The volatiles can have other desirable effects, such as preparing the substrate surface to contain the intrasorbent material. They can have antimicrobial and related properties as well as other useful services.

0035Examples of volatiles include, but are not limited to: halohydrocarbons, siloxanes such as cyclomethicones, derivatives of volatile siloxanes, ethers such as dibuthyl ethers, alcohols such as ethanol and isopropanol, esters such as ethyl acetate, ketones such as methyl ethyl ketone, water and other useful ones , volatile compounds.

D) modifiers

0036The modifiers have a number of useful and valuable properties. For example, modifiers, such as certain dispersants, can increase the containment of the active substances, such as the protective but discolouring gentian violet in the non-volatile matrix. This increases the containment and further reduces the risk of skin discoloration and absorption. Other modifiers can be added to change the following properties. Acids can be used to change the color of dyes. Other additives change the properties of the non-volatile components, for example by adding gelling agents to reduce the spread, or aromatics can be added to the volatile components to increase the cooling effect or to enhance other properties, such as the addition of preservatives.

0037Examples of such modifiers include:<ul id="ul0007" list-style="none"><li>a3) Dispersing agents, such as surface-active compounds with a high HLB value: anionic detergents (eg alkyl acid, alkyl phosphates). Non-ionogens, such as the polysorbates and highly ethoxylated polyoxethylene esters and ethers. Amphoters such as alkylimidazolines and acyl peptides and cationic surfactants such as ethoxylated alkyldimethylammonium salts. On the other hand, certain systems require low HLB dispersants, such as sorbitan fatty acid esters and ethers.</li><li>b3) Gelling and viscosity-increasing additives, such as carbomers, alginates, synthetic cellulose-acrylic polymers and natural water-soluble polymers and gelling agents based on aluminum salts of fatty acids.</li><li>c3) buffers such as acetates, citrates, phosphates, alpha-hydroxy acids etc.</li><li>d3) humectants, plasticizers and plasticizing materials, such as polyethylene glycols, glycerol, propylene, butylene and hexylene glycols, sorbitol, mannitol and pentaerythrol or else hydrophilic or lipophilic polyoxypropylene ethers.</li><li>e3) Volatile aromatics, such as menthol, camphor, menthyl salicylate, eugenol and similar compounds, also fragrance mixtures, spices, etc., and approved dyes and pigments.</li><li>f3) preservatives such as parabens, benzoic acid and sorbic acid, aldehydes and aldehyde-releasing compounds, imidazolidinyl urea, methylchlorisothiazolinones and methylisothiazolinones or antioxidants such as bisulfites, tocopherols, propyl gallate etc.</li></ul>

Application examples of this invention

0038Typical application examples follow below.<ul id="ul0008" list-style="none"><li>a4) Example 1 shows the application of this technique to the known antimicrobial very effective gentian violet. It is only used to a limited extent on the skin today because it turns it purple. Previous attempts to remedy these disadvantages have resulted in the inactivation of the active ingredient. However, as shown in Example 1, when used in the intrasorption system, it retains its biological activity in the aqueous phase; however, the intrasorption matrix prevents absorption and thus discoloration of the skin.</li><li>b4) Another, similar intrasorption technique is shown in Example 4. The antimicrobial polyvinylpyrrolidone-iodine complex stains the skin significantly less if it is present in the intarsorption system. However, its antimicrobial effectiveness remains.</li></ul>

0039As already mentioned, this invention can be used not only on the skin, but also in the hair, on the nails or other protein-containing surfaces. But other surfaces, such as that of wood, other cellulose-containing materials, plastics, metals or ceramics, are also possible.

0040Another use is the use of dyes to achieve coloring without discoloration or interlacing of the substrate. Example 2 shows this for organic dyes and Example 3 for pigments.

0041In both cases, the coloring imparted to the skin is extraordinarily natural because the organic dyes of Example 2 and the inorganic pigments in Example 3 are present in a microdisperse distribution in the intrasorption matrix, which itself is in extremely close contact with the skin. The surprisingly natural color effect is further increased because the intrasorption system prevents the dyes from binding to or penetrating the skin. There is also no accumulation, staining, breaking of a layer or premature or uneven disappearance, which would all lead to an unnatural appearance.

0042Examples 3 and 5 show the use of the intrasorption system to avoid radiation damage, namely example 5 for the benzophenone-2 UV absorber and example 3 for the iron oxide / titanium oxide pigment, which block or reflect the UV radiation, together with the antioxidant tocopherol acetate, which is used as free radical scavenger works. Free radicals occur regularly in biological processes; however, their occurrence is greatly increased by UV radiation. The intrasorption system can be used both for UV filters, to suppress the formation of free radicals and to render them harmless. Then intrasorption technology reduces the loss of effectiveness that is normally caused by the absorption of filter substances through the skin. The uniformity of skin protection is also guaranteed. This advantage is particularly important because the reduction in UV protection through absorption also means reduced protection of the immune system. The absorption of the filter substances through the skin can also lead to skin irritation and eczema and with long-term use toxic effects cannot be excluded.

Further examples of the invention

A1) Protection and prolongation of action of fragrances

0043Fragrances can also be introduced into the intrasorption system and held there, thereby preventing binding to protein or lipid-containing skin areas or to cellulose, plastics or other materials which act as a substrate. Binding normally leads to a loss of fragrance intensity or this can lead to an undesirable change in the fragrance character. This can occur with individual fragrance components as well as with fragrance mixtures that make up most perfumes. The end result is a diminished olfactory experience compared to how it smells on the sales package.

0044This is recorded in Fig. 6. The fragrance is protected against such effects, which creates an appealing fragrance experience. The intrasorption system can now also be modified in such a way that the fragrance release is accelerated or slowed down. This concept can be applied to normal fragrances as well as deodorants and odor eliminators.<ul id="ul0009" list-style="none"><li>B1) Another application of this invention is drug delivery of repellents, such as N, N-diethyl-m-toluamide, and prevention of drug loss through absorption and adsorption. Such advantages can also be achieved with miticides and parasiticides, such as dichlorvos for example (6b).</li><li>C1) In addition to various colors and pigments, this invention can also be used to increase the visual effects of substances which give rise to gloss, metallic luster or a sheen (such as metal stearates, etc.) or other visual, structural effects. It can also be used to protect against excessive application and subsequent loss (example 6c).</li><li>D1) protective effect. The basic system, exemplified by the vehicles in Example 1-6 (but without the active substances), can protect the skin from external influences due to the special property of the intrasorption system of adhering closely to the skin without being firmly attached to it. This is because a practically invisible, fat-free, non-sticky, colorless and odorless protective film is formed, which delays contact with dirt, fat, discolouring or skin-irritating substances and the like. This protective effect can be increased if special additives are incorporated in the basic system. For example, protects Chitosan, when incorporated into the aqueous phase, the skin and its appendages before the degreasing effect of organic solvents (Example 6d).</li><li>E1) The previous application examples related to the skin. However, the same useful effects can also be achieved on other substrates.</li></ul>

0045Hair: Protection against excessive absorption into the hair can result, for example, in an optimal shine, softness of the hair surface, reduced splitting of the hair tips, and less removal of the cuticle. The application, the even distribution and the brilliance of hair colors and pigments are also improved, while the removal of dandruff is made easier.

0046Wood: This can be achieved: increased deposition of care products, protection and beautification of the wood structure, increased gloss, emphasis on the grain and shielding from environmental influences. Additives can further increase the protective effect with regard to radiation as well as microbial and parasite infestation.

0047Plastics: like wood Metals: like wood; additional protection when using agents to prevent corrosion, oxidation, acid attack, etc.

0048Another type of protective effect can be achieved by the intrasorption technology if the absorption of materials is slowed down in such a way that an otherwise occurring impairment due to excessive exposure no longer takes place. For example, the reduction in the absorption of oxidizing agents, such as inorganic and organic peroxides, of aldehydes, such as glutaraldehyde, skin reddening agents caused by skin irritations (Rubefacientia), such as histamine dihydrochloride and possibly skin-irritating but very useful fragrances, such as cinnamon alcohol, sassafras essence, etc. ..

Examples and findings of an impairment

0049It has been found that certain active substances can impair the correct functioning of the intrasorbent, and it is possible to ascertain such effects. For example, the ability of the intrasorbent material to prevent migration of the enclosed substances is severely impaired if dimethicone is partially or completely replaced by amodimethicone, a silicone polymer with a terminal amino group (-NH-CH₂-CH₂-NH₂). An application example of this is obtained when formula A (which is identical to example 2) is compared with formula 2, which also has the same composition as 2, but contains trimethylallylamodimeththicone polymer instead of dimethicone polymers.

0050Approximately 0.25 of both preparations are placed in the center of a round filter apparatus with a diameter of 10-15 cm and for about 30 minutes. let move in. Then leave these filters held vertically about 1 cm wide Immerse water that is between 20 and 35 ° C. In this way, water diffuses through the filter paper.

0051In this experiment, formula A shows which dimethicone polymers contain no bleeding, while the color of formula B, which contains trimethylsilylamodimethicone, shows a strong washout and thus gives an indication that diffusion on the skin and possible absorption take place.

0052Differences only in polarity cannot explain this phenomenon, because certain active substances mentioned in the examples have a pronounced polar character and are contained in a similar or higher concentration than the amodimethicone polymer and yet they do not influence the retention capacity in the intrasorbent material .

0053These and other tests that show resistance to diffusion, absorption or migration can be used to rule out active substances that would impair the desired retention in the intrasorption layer. On the other hand, such investigations can be used to find substances that optimize the retention capacity.

example 1

(CTFA nomenclature)

0054Reduced skin discoloration with gentian violet treatment. <tables id="tabl0001" num="0001"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Non-volatile component</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Jojoba oil</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Dimethicone, high molecular weight</entry><entry namest="col2" nameend="col2" align="char" char=",">1.56 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0002" num="0002"><img file="EP0478906A2_D0001.tif" /></tables><tables id="tabl0003" num="0003"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Active substance</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Gentian violet</entry><entry namest="col2" nameend="col2" align="char" char=",">0.5 parts</entry></row></tbody></tgroup></table></tables>

Modifiers

0055<tables id="tabl0004" num="0004"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">a) Solvent for gentian violet</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Glycereth 26</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">10.85 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0005" num="0005"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">b) Matrix booster to further reduce dye release</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG-40 stearate ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">PEG-25 lauryl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 20</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Polysorbate 40</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0006" num="0006"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">c) Viscosity-increasing and plasticizing substances</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Ceteareth-3</entry><entry namest="col2" nameend="col2" align="char" char=",">0.4 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Ceteareth-6</entry><entry namest="col2" nameend="col2" align="char" char=",">0.2 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0007" num="0007"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">d) preservatives</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Methylchloroisothiazolinone</entry><entry namest="col2" nameend="col2" align="char" char=",">0.05 parts</entry></row></tbody></tgroup></table></tables>

Manufacturing

0056Gentian violet is dissolved in the solvents at 38 ° - 42 ° C with stirring. Then the matrix enhancers, the viscosity and plasticity modifiers and the preservative are added. The non-volatile component is then added. At the end, in order to avoid evaporation losses, the volatile component is added, with stirring while cooling.

Example 2

Surface coloring without coloring the substrate

0057<tables id="tabl0008" num="0008"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Non-volatile components</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Squalane</entry><entry namest="col2" nameend="col2" align="char" char=",">1.8 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Dimethicone, very high viscosity</entry><entry namest="col2" nameend="col2" align="char" char=",">1.3 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0009" num="0009"><img file="EP0478906A2_D0002.tif" /></tables><tables id="tabl0010" num="0010"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Active ingredients</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">FD&amp;C red No. 33</entry><entry namest="col2" nameend="col2" align="char" char=",">0.033 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">FD&amp;C yellow No. 5</entry><entry namest="col2" nameend="col2" align="char" char=",">0.064 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">FD&amp;C blue No. 1</entry><entry namest="col2" nameend="col2" align="char" char=",">0.003 parts</entry></row></tbody></tgroup></table></tables>

Modifiers

0058<tables id="tabl0011" num="0011"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">a) solvents for the dyes</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Propylene glycol</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">11.8 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0012" num="0012"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">b) matrix amplifier</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG-36 oleate ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.4 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">PEG-20 cetyl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.6 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 20</entry><entry namest="col2" nameend="col2" align="char" char=",">6.2 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Sodium lauryl sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">1.4 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0013" num="0013"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">c) viscosity-increasing and plasticizing additives</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Capryl pyrrolidone</entry><entry namest="col2" nameend="col2" align="char" char=",">0.8 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Lauryl pyrrolidone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0014" num="0014"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">d) preservatives</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Imidazolidinyl urea</entry><entry namest="col2" nameend="col2" align="char" char=",">0.2 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0 parts</entry></row></tbody></tgroup></table></tables>

Manufacturing

0059At 38 ° - 42 ° C, the FD&amp;C colors are dissolved in the solvent with stirring, then the matrix enhancers, the viscosity-increasing, the plasticizing and preserving additives are added. Then the non-volatile components are added and finally, in a closed vessel to avoid evaporation losses, the volatile components. It is stirred well until a homogeneous mass is formed - then the mixture is cooled to room temperature with stirring.

Example 3

0060Deepening of the complexion and protection of the skin with pigments, UV dispersants and free radical scavengers. <tables id="tabl0015" num="0015"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Non-volatile component</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PPG 40 butyl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.9 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Dimethyl trimethyl polysiloxane</entry><entry namest="col2" nameend="col2" align="char" char=",">12.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0016" num="0016"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Volatile components</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Cyclomethicone D</entry><entry namest="col2" nameend="col2" align="char" char=",">56.75 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0017" num="0017"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Active substances</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Wackherr W 9814 black iron oxide pigment</entry><entry namest="col2" nameend="col2" align="char" char=",">0.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Wackherr W 3801 red iron oxide pigment</entry><entry namest="col2" nameend="col2" align="char" char=",">0.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Wackherr W 1803 yellow iron oxide pigment</entry><entry namest="col2" nameend="col2" align="char" char=",">0.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Titanium dioxide</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Tocopherol acetate</entry><entry namest="col2" nameend="col2" align="char" char=",">0.5 parts</entry></row></tbody></tgroup></table></tables>

Modifiers

0061<tables id="tabl0018" num="0018"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">a) pigment dispersant</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Sorbitol</entry><entry namest="col2" nameend="col2" align="char" char=",">2.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Glycereth-26</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">10.5 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0019" num="0019"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">b) matrix amplifier</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG-40 stearate ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">PEG-25 lauryl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 20</entry><entry namest="col2" nameend="col2" align="char" char=",">4.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 40</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Sodium lauryl sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">1.3 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0020" num="0020"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">c) preservatives</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Methylchloroisothiazolinone</entry><entry namest="col2" nameend="col2" align="char" char=",">0.05 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0 parts</entry></row></tbody></tgroup></table></tables>

Manufacturing

0062While stirring, the iron oxide and titanium dioxide pigments are finely distributed in the dispersant in a closed container at 40 - 45 ° C. Then the matrix amplifier is added and the preservative dissolved in the water is added. The tocopherol acetate is then added to the mixture of non-volatile components and mixed. Finally, the cyclomethicone is slowly added, stirred until a uniform mixture is formed and then cooled.

Example 4

Non-staining iodine / polyvinylpyrrolidone disinfectant

0063<tables id="tabl0021" num="0021"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Non-volatile components</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PPG-40 butyl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.9 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Dimethyl / trimethyl polysiloxane</entry><entry namest="col2" nameend="col2" align="char" char=",">12.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0022" num="0022"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Volatile Shares</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Cyclomethicone D₄ / D₅</entry><entry namest="col2" nameend="col2" align="char" char=",">56.3 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0023" num="0023"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Active ingredients</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Povidone iodine</entry><entry namest="col2" nameend="col2" align="char" char=",">5.0 parts</entry></row></tbody></tgroup></table></tables>

Modifiers

Modifiers

0065<tables id="tabl0024" num="0024"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">a) Povidone iodine solvent</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">2.5 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">12.5 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0025" num="0025"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">b) matrix amplifier</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG-40 stearate ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">PEG-25 lauryl ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 20</entry><entry namest="col2" nameend="col2" align="char" char=",">5.5 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Sodium laurite sulfate</entry><entry namest="col2" nameend="col2" align="char" char=",">1.3 parts</entry></row></tbody></tgroup></table></tables>

Manufacturing

0066The iodine / polyvinyl pyrrolidone are dissolved in the glycerol / water mixture in a closed container with stirring. Then the matrix enhancers and the non-volatile components are added, followed by the cyclomethicone. The mixture is stirred until uniform and then cooled.

Example 5

0067Extension of the effectiveness of UV filter substances.

0068This concept delays the reduction in effectiveness that normally results from the absorption of the UV filter substances by the skin. This can be particularly important:<ul id="ul0010" list-style="none"><li>a) to protect the immune system of the skin, which is reduced by the absorption of the filter substances</li><li>b) because the absorption of the filter substances lead to toxicological problems.</li></ul><tables id="tabl0026" num="0026"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Non-volatile components</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Ultra high viscosity dimethicone</entry><entry namest="col2" nameend="col2" align="char" char=",">1.56 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0027" num="0027"><img file="EP0478906A2_D0003.tif" /></tables><tables id="tabl0028" num="0028"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Active ingredient</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Benzophenone-2</entry><entry namest="col2" nameend="col2" align="char" char=",">1.0 parts</entry></row></tbody></tgroup></table></tables>

Modifiers

0069<tables id="tabl0029" num="0029"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">a) Solvent for benzophenone-2</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Glycerin</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">12.85 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0030" num="0030"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">b) matrix amplifier to reduce absorption</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG-40 stearate ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">PEG-25 lauryl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 20</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Polysorbate 40</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0031" num="0031"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">c) viscosity-increasing and plasticizing additives</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Ceteareth-3</entry><entry namest="col2" nameend="col2" align="char" char=",">0.4 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Ceteareth-6</entry><entry namest="col2" nameend="col2" align="char" char=",">0.2 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0032" num="0032"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">d) preservatives</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Methylchloroisothiazolinone</entry><entry namest="col2" nameend="col2" align="char" char=",">0.05 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row></tbody></tgroup></table></tables>

Manufacturing

0070The benzophenone-2 is dissolved in its solvent in a closed container at 38 ° - 42 ° C, then the matrix enhancers, the viscosity-increasing and plasticizing components and the preservative are added, then the non-volatile dimethicone and finally the volatile components. It is stirred until a uniform mass is formed and then cooled with stirring.

Examples 6A-6D

0071<tables id="tabl0033" num="0033"><img file="EP0478906A2_D0004.tif" /></tables>

Modifiers

0072<tables id="tabl0034" num="0034"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">a) Solvent for gentian violet</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG 400</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Glycereth 26</entry><entry namest="col2" nameend="col2" align="char" char=",">2.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">water</entry><entry namest="col2" nameend="col2" align="char" char=",">10.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0035" num="0035"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">b) matrix amplifier</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">PEG-40 stearate ester</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">PEG-25 lauryl ether</entry><entry namest="col2" nameend="col2" align="char" char=",">1.5 parts</entry></row><row><entry namest="col1" nameend="col1" align="left">Polysorbate 20</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Polysorbate 40</entry><entry namest="col2" nameend="col2" align="char" char=",">3.0 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0036" num="0036"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">c) viscosity-increasing and plasticizing additives</entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Ceteareth-3</entry><entry namest="col2" nameend="col2" align="char" char=",">0.4 parts</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Ceteareth-6</entry><entry namest="col2" nameend="col2" align="char" char=",">0.2 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0037" num="0037"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">d) preservatives</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Methylchloroisothiazolinone</entry><entry namest="col2" nameend="col2" align="char" char=",">0.05 parts</entry></row></tbody></tgroup></table></tables><tables id="tabl0038" num="0038"><img file="EP0478906A2_D0005.tif" /></tables><tables id="tabl0039" num="0039"><table frame="all"><tgroup cols="2" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="78.75mm" /><colspec colnum="2" colname="col2" colwidth="78.75mm" /><thead valign="top"><row><entry namest="col1" nameend="col2" align="center">Volatile components</entry></row></thead><tbody valign="top"><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Cyclomethicone (tetramer) to total</entry><entry namest="col2" nameend="col2" align="char" char=",">100.0 parts</entry></row></tbody></tgroup></table></tables>

Manufacturing

0073In a closed container, the active substances intended for the corresponding examples are dissolved in the modifying agents a), b), c) and d), then the non-volatile components are added, and finally the cyclomethicone (tetramer). It is stirred until a homogeneous mass has formed and then cooled.