EP0467031A3

Medical-grade lipid-coated microbubbles, paramagnetic labelling thereof and their therapeutic use

Abstract

This invention relates to a large scale method for the production of medical grade lipid-coated microbubbles, to the paramagnetic labeling of such microbubbles and to therapeutic applications for the microbubbles. More particularly, the invention relates to a method of the production of medical grade, concentrated suspensions of stable, paramagnetically derivatized or underivatized microbubbles useful for ultrasonic and magnetic resonance imaging and also relates to therapeutic interventions such as selective tumor destruction.

EP0467031A3, drawing sheet 1 — Sheet 1 of 1

Term

Term ended

Projected expiry passed 13 May 2011, 15.4 years ago.

1 sheet

Sheet 1

Every citation, both ways

Citations
Document	Relation	Office	Category	Cited during
EP0160552A2	Cites	European Patent Office (EPO)	X	Search report
EP0272091A2	Cites	European Patent Office (EPO)	X	Search report
US4684479A	Cites	United States of America	XD	Search report
US4900540A	Cites	United States of America	X	Search report
WO8905160A1	Cites	World Intellectual Property Organization (WIPO)	X	Search report
INVESTIGATIVE RADIOLOGY, vol. 25, December 1990, pages 1300-1304, Philadelphia, PA, US; R.H. SIMON et al.: "Lipid-coated ultrastable microbubbles as a contrast agent in neurosonography"	Non-patent	–	–	Search report
MAGNETIC RESONANCE IN MEDICINE, vol. 3, 1986, pages 541-548, Academic Press, Inc., New York, US; R.B. LAUFFER et al.: "1/T1 NMRD profiles of solutions of Mn2+ and Gd3+ protein-chelate conjugates"	Non-patent	–	–	Search report

10 members in 5 offices; this record represents the family

This recordMember, by publication datePriority claim

Priority claims2

Priority claims
Document	Office	Kind	Date
550620	United States of America	–	1990-07-10
55062090	United States of America	A	1990-07-10

Members10

Family members, oldest first
Document	Office	Kind
AU8029791A	Australia	A	1992-01-16
EP0467031A2	European Patent Office (EPO)	A2	1992-01-22
EP0467031A3This record	European Patent Office (EPO)	A3	1992-11-25
US5215680A	United States of America	A	1993-06-01
AU657480B2	Australia	B2	1995-03-16
EP0467031B1	European Patent Office (EPO)	B1	1997-07-30
AT156020T	Austria	T	1997-08-15
ATE156020T1	Austria	T1	1997-08-15
DE69127032D1	Germany	D1	1997-09-04
DE69127032T2	Germany	T2	1998-02-26

42 legal events, as 4 offices reported them to INPADOC

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	Event	Code	Office
2013-06-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2011-06-01	Patent expired after termination of 20 yearsExpiredPE20	PE20	GB
2011-05-13	Expiry of rightR071	R071	DE
2010-08-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2010-08-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2010-07-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2010-06-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2002-01-01	European patent in force as of 2002-01-01IF02	IF02	GB
1998-09-09	Correction of patent specification (complete document) publishedK2C3	K2C3	EP
1998-07-22	No opposition filedOpposition26N	26N	EP
1998-06-05	No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE	PLBE	EP
1998-06-05	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA	STAA	EP
1998-05-13	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1998-01-30	Patent ceasedCeasedPL	PL	CH
1998-01-05	Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents actLapsedNLV1	NLV1	EP
1997-12-05	Fr: translation filedET	ET	EP
1997-10-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-10-21	It: translation for a ep patent filedITF	ITF	EP
1997-10-21	It: translation for a ep patent filedITF	ITF	EP
1997-09-04	Corresponds to:REF	REF	EP
1997-07-31	European patent takes effect as a national patent in ch/liEP	EP	CH
1997-07-30	Designated contracting statesAK	AK	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
1997-07-30	Corresponds to:REF	REF	EP
1997-06-13	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
1997-02-07	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOS IGRAGRAH	GRAH	EP
1996-11-06	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOS IGRAGRAH	GRAH	EP
1996-07-03	Despatch of communication of intention to grantORIGINAL CODE: EPIDOS AGRAGRAG	GRAG	EP
1995-06-21	First examination report despatched17Q	17Q	EP
1993-06-23	Request for examination filed17P	17P	EP
1992-11-25	Designated contracting statesAK	AK	EP
1992-10-05	Search report despatchedORIGINAL CODE: 0009013PUAL	PUAL	EP
1992-01-22	Designated contracting statesAK	AK	EP
1991-12-07	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Medical-grade lipid-coated microbubbles, paramagnetic labelling thereof and their therapeutic use

Abstract

Term

Priority claims2

Members10

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Titles3

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Designated states14