Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of submicronic liposomes
Abstract
Process for the preparation of colloidal dispersible systems of amphiphilic lipids, in the form of submicron oligolamellar liposomes, whose wall is constituted by lipids and optionally of a substance A and whose nucleus is constituted by water or an aqueous solution , and optionally containing a substance B, characterized in that: (1) a liquid phase consisting essentially of a solution of the lipids and optionally of the substance A in a solvent or a mixture of solvents is prepared, and may contain the substance B in solution, (2) a second liquid phase consisting essentially of water or an aqueous solution of the substance B is prepared, (3) the first phase is added, with moderate stirring, to the second phase, so as to obtain ,a colloidal suspension of liposomes, (4) if desired, removing all or part of the solvent or mixture of solvents and water, so as to obtain a colloidal suspension of desired concentration of liposomes. Applications: drugs, cosmetics.
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Projected expiry passed 28 June 2009, 17.2 years ago.
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Every citation, both waysCites: the store holds 3 of 4
| Document | Relation | Office | Category | Cited during |
|---|---|---|---|---|
| EP0130577A2 | Cites | European Patent Office (EPO) | X | Search report |
| EP0190050B1 | Cites | European Patent Office (EPO) | A | Search report |
| GB2002319A | Cites | United Kingdom | X | Search report |
| STN FILE SUPPLIER (Karlsruhe) & FILE CA & CHEMICAL ABSTRACTS, vol. 102, 1984, no. 138256u, New York, US; L. RYDHAG et al.: "Colloidal stability of liposomes", & SURFACTANTS SOLUTION, ÄPROC. INT. SYMP.Ü, 4TH, MEETING DATE 1982, VOLUME 3, 2039-57 | Non-patent | – | – | Search report |
31 members in 10 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 8808874 | France | A | |
| 8808874 | France | – | |
| 8808874 | – | – | – |
| FR19880008874 | – | – | – |
Members31
| Document | Office | Kind | |
|---|---|---|---|
| FR2608942A1 | France | A1 | |
| EP0274961A1 | European Patent Office (EPO) | A1 | |
| JPS63232840A | Japan | A | |
| EP0349429A2 | European Patent Office (EPO) | A2 | |
| FR2634375A1 | France | A1 | |
| KR900000074A | Republic of Korea | A | |
| JPH02149336A | Japan | A | |
| EP0349429A3This record | European Patent Office (EPO) | A3 | |
| FR2608942B1 | France | B1 | |
| FR2634375B3 | France | B3 | |
| US5049322A | United States of America | A | |
| CA1293170C | Canada | C | |
| EP0274961B1 | European Patent Office (EPO) | B1 | |
| AT74025T | Austria | T | |
| DE3777793D1 | Germany | D1 | |
| ES2031529T3 | Spain | T3 | |
| US5174930A | United States of America | A | |
| EP0349429B1 | European Patent Office (EPO) | B1 | |
| AT85888T | Austria | T | |
| GR3004198T3 | Greece | T3 | |
| DE68904999D1 | Germany | D1 | |
| GR3007265T3 | Greece | T3 | |
| DE68904999T2 | Germany | T2 | |
| ES2054053T3 | Spain | T3 | |
| JPH0693998B2 | Japan | B2 | |
| JPH0824840B2 | Japan | B2 | |
| KR960014869B1 | Republic of Korea | B1 | |
| EP0349429B2 | European Patent Office (EPO) | B2 | |
| ES2054053T5 | Spain | T5 | |
| GR3022121T3 | Greece | T3 | |
| DE68904999T3 | Germany | T3 |
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| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
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| Nl: receipt of modified translations in the netherlands language after an opposition procedureOppositionNLR3 | NLR3 | EP | |
| Gb: translation of amended ep patent filed (gb section 77(6)(b)/1977)GBTA | GBTA | EP | |
| Patent modifiedDC2A | DC2A | ES | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Scope or validity of the patent modifiedMAINTIEN DU BREVET DONT L'ETENDUE A ETE MODIFIEEAEN | AEN | CH | |
| Patent maintained in amended form27A | 27A | EP | |
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| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: PATENT MAINTAINED AS AMENDEDSTAA | STAA | EP | |
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| Interlocutory decision in oppositionOppositionORIGINAL CODE: EPIDOS IDOPPLAW | PLAW | EP | |
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| Nl: opposition has been filed with the epoOppositionNLR1 | NLR1 | EP | |
| Nl: opposition has been filed with the epoOppositionNLR1 | NLR1 | EP | |
| Opposition filedOpposition26 | 26 | EP | |
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| Opposition filedOppositionORIGINAL CODE: 0009260PLBI | PLBI | EP | |
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| Validation in greece3007265FG4A | FG4A | GR | |
| It: translation for a ep patent filedITF | ITF | EP | |
| It: translation for a ep patent filedITF | ITF | EP | |
| Gb: translation of ep patent filed (gb section 77(6)(a)/1977)GBT | GBT | EP | |
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| (expected) grantORIGINAL CODE: 0009210GRAA | GRAA | EP | |
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Numbers
- Publication
- 0349429
- Publication, DOCDB
- 0349429
- Publication, EPODOC
- EP0349429
- Application
- 89401857
- Application, DOCDB
- 89401857
- Application, EPODOC
- EP19890401857
Titles3
- English
- PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL SYSTEMS OF AMPHIPHILIC LIPIDS IN THE FORM OF SUBMICRONIC LIPOSOMES
- German
- Verfahren zur Herstellung dispergierbarer kolloidaler Systeme aus amphiphilen Lipiden in Form von Liposomen in Submikrongrösse
- French
- Procédé de préparation de systèmes colloidaux dispersibles de lipides amphiphiles sous forme de liposomes submicroniques
Classification
- CPC, 1
- A61K9/1277
- IPC, 5
- A61K8 11
- A61K8 14
- A61K8 34
- A61K9 127
- B01J13 02
Designated states1
- Contracting states, 1
- Sweden