N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives

A compound selected from the group consisting of a glutamic acid derivative of the formula: in which:<br /> R¹ is -OH or -NH₂;<br /> R² is hydrogen or a carboxy protecting group;<br /> R³ is a carbon-carbon bond, alkylene of 1 to 4 car­bon atoms, cyclohexylene, or R⁴ is hydrogen or an amino protecting group;<br /> Q is -S- or -O-;<br /> R⁵ is hydrogen, chloro or fluoro; and<br /> the configuration about the carbon atom designated * is S; and<br /> the pharmaceutically acceptable salts thereof. Also disclosed is a method of combatting neoplastic growth in a mammal and a pharmaceutical composition for combatting neoplastic growth in a mammal making use of the above compound.