Halobutyl thermoplastic elastomer.

<u style="single">FIELD OF THE INVENTION</u>

The present invention relates to a halobutyl-based vulcanized thermoplastic elastomer which can be used in the pharmaceutical industry for products such as vial stoppers, blood tube stoppers, dropper bulbs and syringe tips. The product does not employ a zinc containing component.

<u style="single">BACKGROUND OF THE INVENTION</u>

Elastomeric compositions in which butyl rubber is dynamically vulcanized in the presence of polyolefins such as polypropylene have resulted in thermoplastic compositions which have been proposed for use for most applications where thermoplastic elastomers would be of advantage. However, many of the products produced by the dynamic vulcanization of butyl rubber in the presence of materials such as polypropylene have not resulted in products which are suitable for vial stoppers, blood tube stoppers and dropper bulb applications, for example, in the pharmaceutical industry. Because of extremely high quality control and concern for the integrity of the product contained in pharmaceutical containers, thermoplastic elastomers have been slow to be accepted as candidates for container closures, vials, stoppers, dropper bulbs and the like. The product must have mechanical strength and set resistance properties, but also must provide moisture and oxygen barriers while not allowing undesirable materials to be extracted from the product. Until the present time, such a material has not been developed which has all of the required properties for use successfully in the pharmaceutical industry.

United States Patent No. 4,130,534 describes a thermoplastic composition containing polyolefin resins and cross-linked butyl rubber. The product is formed by dynamic vulcanization, in which the rubber is the continuous phase prior to cross-linking but becomes the dispersed phase after the cross-linking step.

United States Patent No. 4,501,842 describes an adhesive in which a halogenated butyl rubber is combined with a styrene/ethylene butylene/styrene block thermoplastic polymer (SEBS) and other materials to form an effective adhesive. Zinc oxide is used as a strength increaser.

United States Patent No. 4,593,062 describes the combination of polyolefins, halogenated butyl rubber and polychloroprene in which these rubbers are dynamically vulcanized in the presence of the polyolefin. This patent contains an extensive description of the dynamic vulcanization process.

United States Patent No. 4,607,074 combines polypropylene, a zinc oxide cured halogenated butyl rubber, and a second rubber, preferably EPDM. Various curing agents are suggested for curing the rubber during dynamic vulcanization, including accelerators which assist the zinc oxide cure.

United States Patent No. 4,616,052 describes elastomeric compositions which are used as stoppers and syringe plunger tips. The principal component of the product is a dynamically vulcanized ethylene-propylene-diene terpolymer and polypropylene mixed with butyl rubber in the range of perhaps 5 to about 20 percent. A hindered amine is present to act as a stabilizer.

United States Patent No. 4,616,064 describes a mixture of polyolefins, SEBS polymers and materials such as polysiloxanes.

One particular method for preparing halogenated butyl rubbers through isomerization is described in United States Patent No. 4,634,741. All of the cure processes for these butyl rubbers are based upon a zinc oxide cure system.

United States Patent No. 4,639,487 describes a different system using a butyl rubber mixed into an ethylene copolymer resin which is dynamically vulcanized. The preferred curing agent contains zinc oxide.

None of the systems described above are capable of providing the ideal composition for use in the pharmaceutical industry. Accordingly, it is an object of this invention to provide a thermoplastic elastomer composition which is suitable for use as a vial stopper, blood tube stopper, dropper bulb or syringe tip in the pharmaceutical industry and which is useful in other applications where low hardness and a good barrier to moisture and oxygen is needed.

<u style="single">SUMMARY OF THE INVENTION</u>

The present invention provides a thermoplastic elastomer composition in which a halobutyl rubber is cured by dynamic vulcanization. A multifunctional amine curing agent is employed. The cure is effected in the presence of a mixture formed from polyolefins and thermoplastic elastomers. These compositions have properties which are highly desirable for use in the pharmaceutical industry, and are zinc free.

Specifically, the present invention comprises a halobutyl rubber which is cured by dynamic vulcanization, using a multifunctional amine curing agent, such that the cure is effected in the presence of at least 20 and preferably from about 20 to about 100 parts of a mixture formed from about 10 parts to 60 parts of a polyolefin and about 1 to about 90 parts of a thermoplastic elastomer. All of the parts are based on 100 parts by weight of the halobutyl rubber.

The preferred polyolefins are polypropylene and polyethylene. The preferred thermoplastic elastomers are thermoplastic, elastomeric block copolymers having terminal polystyrene units.

<u style="single">DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT</u>

As is noted in U.S. Patent No. 4,634,741, one of the first olefinically unsaturated synthetic elastomers to be commercially produced was butyl rubber. The expression butyl rubber is broadly understood to be the product made from a copolymerization of isobutylene and isoprene. For the purposes of this invention, any of the butyl rubbers which are commercially available may be used in the composition of this invention. Halobutyl rubbers are those butyl rubbers which have been halogenated with either chlorine or bromine. Again, the commercially available halogenated butyl rubbers are suitable for use in the present invention.

The concept of dynamic vulcanization of butyl rubbers and polyolefins is extensively described in U.S. Patent No. 4,130,534 to Coran et al, the disclosure of which is incorporated herein. Detailed therein are definitions of butyl rubber and halogenated butyl rubber. Also described are various thermoplastic olefin resins such as polyethylene, and polypropylene, among others. Polypropylene is the preferred polyolefin of the present invention. Based upon 100 parts of the halobutyl rubber, the amount of polyolefin will range from about 10 to about 60 parts by weight. Most preferred are about 15 to about 30 parts polypropylene per 100 parts of rubber. Also preferred is polyethylene in the same proportions.

The thermoplastic elastomer of the present invention, which forms the final component of the thermoplastic elastomer is present in an amount ranging from about 1.0 to about 90 parts of thermoplastic elastomer based upon 100 parts of the halobutyl rubber. Preferred is from about 18 to about 50 parts of thermoplastic elastomers. A most preferred amount is from about 15 to about 35 parts by weight. The thermoplastic elastomer is combined with the polyolefin to form a mixture which forms the continuous phase during the dynamic vulcanization of the halobutyl rubber. Prior to crosslinking, the butyl rubber is the continuous phase and the polyolefin and thermoplastic elastomers are added. During crosslinking of the halobutyl rubber, it becomes dispersed and, upon vigorous mixing, becomes particulate throughout the continuous phase of the mixture of polyolefin and thermoplastic elastomer. Normally, from about 25 to about 160 parts of mixture is needed per 100 parts of rubber.

Various thermoplastic elastomers may be employed with success in the present invention. Particularly preferred are thermoplastic elastomeric block copolymers having terminal polystyrene units. Most preferred are the ethylene, butylene, block copolymers which have terminal polystyrene units and which function as thermoplastic elastomers. These polymers are commercially available from Shell Chemical Company under the trademark <b>KRATON G</b>. Block copolymers described in U.S. Patent No. 3,686,364 and U.S. Patent No. 3,865,776 are typical examples of the block copolymers contemplated by the present invention. In the latter patent, assigned to Shell Oil Company, copolymers are described as having ethylene butylene central blocks of from 50 to 80 percent by weight of the copolymer molecule in approximately equal proportions of ethylene and butylene. The terminal blocks are polystyrene. These ethylene, butylene block copolymers having terminal polystyrene units are referred to by the shorthand designation of SEBS copolymers. SEBS copolymers are the preferred thermoplastic elastomer which is to be used to form a mixture prior to dynamic vulcanization of the halobutyl rubber. Other thermoplastic elastomeric block copolymers with terminal polystyrene units are also preferred. Among these are butylene polymers and isobutylene polymers, referred to by SBS and SIS. These are also available under the trademark <b>KRATON</b>.

Another class of thermoplastic elastomers which is useful in the present invention is the group generally known as olefinic thermoplastic elastomers. These products are available commercially.

A third class of thermoplastic elastomers which is useful in the present invention is based on a multiplicity of recurring short-chain ester units and long-­chain ester units joined through ester linkages. These polyester resins are available, for example, from the DuPont Company under the tradename <b>HYTREL</b>.

There are, of course, other thermoplastic elastomers which may be employed in the present invention. All that is necessary is that the thermoplastic elastomer be suitable for forming a continuous, though not necessarily homogeneous, phase in a mixture with the polyolefin during the dynamic vulcanization stage.

The dynamic vulcanization of the halobutyl rubber is carried out with a multifunctional amine curing agent. The curing agent, containing a diamine function, is very active, normally considered far too fast for straight vulcanization. Any diamine function which is slow enough to be mixed into the system and fast enough to react during dynamic vulcanization is appropriate. Stated another way, if a diamine curing agent can be incorporated into the system, it can operate to dynamically vulcanize the halobutyl rubber. One preferred curing agent is hexamethylene diamine carbamate, which is a blocked diamine having carbon dioxide blocking the amine function to form a carbamate. When heated, carbon dioxide is driven off to immediately cause a reaction during the dynamic vulcanization. Materials of this type are available under the tradename <b>DIAK</b>. <b>DIAK</b> is manufactured by the DuPont Company.

The amount of curing agent will be that amount necessary for a complete cure of the halobutyl rubber and will broadly range from less than one part to more than 6 parts of curing agent per 100 parts of halobutyl rubber. For bromobutyl rubber, the diamine can range from 1 phr to 3 phr, with a preferred range of 1.6 to 2.5 phr. For chlorobutyl rubber, 2 to 6 phr has been effective, and 3 phr to 5 phr is preferred. The exact amount of diamine will be sufficient to effect the cure without detrimental effects of overcure.

A number of experiments were performed to demonstrate the efficacy of the present invention. In one series of experiments, dynamic vulcanization of bromobutyl rubber was effected using 2 parts per 100 parts of bromobutyl rubber of a hexamethylene diamine carbamate curing agent. The amount of polyolefin and thermoplastic elastomer were varied, and various properties were maasured. Specifically, compression set, 100% modulus, tensile strength, and hardness were measured. Presented below in Table I are the results of those tests. <tables id="tabl0001" num="0001"><table frame="all"><title>TABLE I</title><tgroup cols="7" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="22.50mm" /><colspec colnum="2" colname="col2" colwidth="22.50mm" /><colspec colnum="3" colname="col3" colwidth="22.50mm" /><colspec colnum="4" colname="col4" colwidth="22.50mm" /><colspec colnum="5" colname="col5" colwidth="22.50mm" /><colspec colnum="6" colname="col6" colwidth="22.50mm" /><colspec colnum="7" colname="col7" colwidth="22.50mm" /><thead valign="top"><row><entry namest="col1" nameend="col1" align="left"><u style="single">Experiment No.</u></entry><entry namest="col2" nameend="col2" align="center"><u style="single">Polypropylene phr</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">SEBS phr</u></entry><entry namest="col4" nameend="col4" align="center"><u style="single">Compression set</u></entry><entry namest="col5" nameend="col5" align="center"><u style="single">100% modulus psi</u></entry><entry namest="col6" nameend="col6" align="center"><u style="single">Tensile psi</u></entry><entry namest="col7" nameend="col7" align="center"><u style="single">Hardness Shore A</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="right">1</entry><entry namest="col2" nameend="col2" align="right">25</entry><entry namest="col3" nameend="col3" align="right">33</entry><entry namest="col4" nameend="col4" align="right">25</entry><entry namest="col5" nameend="col5" align="right">282</entry><entry namest="col6" nameend="col6" align="right">1285</entry><entry namest="col7" nameend="col7" align="right">55</entry></row><row><entry namest="col1" nameend="col1" align="right">2</entry><entry namest="col2" nameend="col2" align="right">22</entry><entry namest="col3" nameend="col3" align="right">33</entry><entry namest="col4" nameend="col4" align="right">16</entry><entry namest="col5" nameend="col5" align="right">280</entry><entry namest="col6" nameend="col6" align="right">725</entry><entry namest="col7" nameend="col7" align="right">53</entry></row><row><entry namest="col1" nameend="col1" align="right">3</entry><entry namest="col2" nameend="col2" align="right">18</entry><entry namest="col3" nameend="col3" align="right">33</entry><entry namest="col4" nameend="col4" align="right">18</entry><entry namest="col5" nameend="col5" align="right">253</entry><entry namest="col6" nameend="col6" align="right">615</entry><entry namest="col7" nameend="col7" align="right">52</entry></row><row><entry namest="col1" nameend="col1" align="right">4</entry><entry namest="col2" nameend="col2" align="right">10</entry><entry namest="col3" nameend="col3" align="right">10</entry><entry namest="col4" nameend="col4" align="right">15</entry><entry namest="col5" nameend="col5" align="right">348</entry><entry namest="col6" nameend="col6" align="right">480</entry><entry namest="col7" nameend="col7" align="right">50</entry></row><row><entry namest="col1" nameend="col1" align="right">5</entry><entry namest="col2" nameend="col2" align="right">20</entry><entry namest="col3" nameend="col3" align="right">20</entry><entry namest="col4" nameend="col4" align="right">22</entry><entry namest="col5" nameend="col5" align="right">575</entry><entry namest="col6" nameend="col6" align="right">1070</entry><entry namest="col7" nameend="col7" align="right">65</entry></row><row><entry namest="col1" nameend="col1" align="right">6</entry><entry namest="col2" nameend="col2" align="right">40</entry><entry namest="col3" nameend="col3" align="right">40</entry><entry namest="col4" nameend="col4" align="right">31</entry><entry namest="col5" nameend="col5" align="right">645</entry><entry namest="col6" nameend="col6" align="right">1700</entry><entry namest="col7" nameend="col7" align="right">77</entry></row><row><entry namest="col1" nameend="col1" align="right">7</entry><entry namest="col2" nameend="col2" align="right">60</entry><entry namest="col3" nameend="col3" align="right">60</entry><entry namest="col4" nameend="col4" align="right">37</entry><entry namest="col5" nameend="col5" align="right">770</entry><entry namest="col6" nameend="col6" align="right">2080</entry><entry namest="col7" nameend="col7" align="right">85</entry></row><row><entry namest="col1" nameend="col1" align="right">8</entry><entry namest="col2" nameend="col2" align="right">80</entry><entry namest="col3" nameend="col3" align="right">80</entry><entry namest="col4" nameend="col4" align="right">47</entry><entry namest="col5" nameend="col5" align="right">720</entry><entry namest="col6" nameend="col6" align="right">2250</entry><entry namest="col7" nameend="col7" align="right">86</entry></row><row><entry namest="col1" nameend="col1" align="right">9</entry><entry namest="col2" nameend="col2" align="right">50</entry><entry namest="col3" nameend="col3" align="right">30</entry><entry namest="col4" nameend="col4" align="right">41</entry><entry namest="col5" nameend="col5" align="right">730</entry><entry namest="col6" nameend="col6" align="right">1580</entry><entry namest="col7" nameend="col7" align="right">82</entry></row><row><entry namest="col1" nameend="col1" align="right">10</entry><entry namest="col2" nameend="col2" align="right">50</entry><entry namest="col3" nameend="col3" align="right">10</entry><entry namest="col4" nameend="col4" align="right">33</entry><entry namest="col5" nameend="col5" align="right">845</entry><entry namest="col6" nameend="col6" align="right">1830</entry><entry namest="col7" nameend="col7" align="right">86</entry></row><row><entry namest="col1" nameend="col1" align="right">11</entry><entry namest="col2" nameend="col2" align="right">30</entry><entry namest="col3" nameend="col3" align="right">50</entry><entry namest="col4" nameend="col4" align="right">51</entry><entry namest="col5" nameend="col5" align="right">490</entry><entry namest="col6" nameend="col6" align="right">810</entry><entry namest="col7" nameend="col7" align="right">67</entry></row><row><entry namest="col1" nameend="col1" align="right">12</entry><entry namest="col2" nameend="col2" align="right">10</entry><entry namest="col3" nameend="col3" align="right">50</entry><entry namest="col4" nameend="col4" align="right">70</entry><entry namest="col5" nameend="col5" align="right">225</entry><entry namest="col6" nameend="col6" align="right">390</entry><entry namest="col7" nameend="col7" align="right">49</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="right">13</entry><entry namest="col2" nameend="col2" align="right">50</entry><entry namest="col3" nameend="col3" align="right">----</entry><entry namest="col4" nameend="col4" align="right">33</entry><entry namest="col5" nameend="col5" align="right">840</entry><entry namest="col6" nameend="col6" align="right">1900</entry><entry namest="col7" nameend="col7" align="right">86</entry></row></tbody></tgroup></table></tables>

Various other components making up the continuous phase mixture were evaluated and results are summarized in Table II below. Specifically, polyethylene and polypropylene were both evaluated as the polyolefin, based on 100 parts of bromobutyl rubber and 2 parts of <b>DIAK 1</b> curing agent. Various thermoplastic elastomers were also used at a 40 parts per 100 parts of rubber level. SEBS was used with both polypropylene and polyethylene. Also, tested were two polyesters. <tables id="tabl0002" num="0002"><table frame="all"><title>TABLE II</title><tgroup cols="5" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="31.50mm" /><colspec colnum="2" colname="col2" colwidth="31.50mm" /><colspec colnum="3" colname="col3" colwidth="31.50mm" /><colspec colnum="4" colname="col4" colwidth="31.50mm" /><colspec colnum="5" colname="col5" colwidth="31.50mm" /><thead valign="top"><row><entry namest="col1" nameend="col1" align="left"><u style="single">Experiment No.</u></entry><entry namest="col2" nameend="col2" align="center"><u style="single">Polyolefin phr</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">TPE phr</u></entry><entry namest="col4" nameend="col4" align="center"><u style="single">Compression set</u></entry><entry namest="col5" nameend="col5" align="center"><u style="single">Tensile psi</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="right">14</entry><entry namest="col2" nameend="col2" align="left">polypropylene, 40</entry><entry namest="col3" nameend="col3" align="left">SEBS, 40</entry><entry namest="col4" nameend="col4" align="right">31</entry><entry namest="col5" nameend="col5" align="right">1700</entry></row><row><entry namest="col1" nameend="col1" align="right">15</entry><entry namest="col2" nameend="col2" align="left">polyethylene, 40</entry><entry namest="col3" nameend="col3" align="left">SEBS, 40</entry><entry namest="col4" nameend="col4" align="right">40</entry><entry namest="col5" nameend="col5" align="right">800</entry></row><row><entry namest="col1" nameend="col1" align="right">16</entry><entry namest="col2" nameend="col2" align="left">polypropylene, 40</entry><entry namest="col3" nameend="col3" align="left">Polyester, 40</entry><entry namest="col4" nameend="col4" align="right">39</entry><entry namest="col5" nameend="col5" align="right">850</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="right">17</entry><entry namest="col2" nameend="col2" align="left">polypropylene, 40</entry><entry namest="col3" nameend="col3" align="left">Polyester, 40</entry><entry namest="col4" nameend="col4" align="right">38</entry><entry namest="col5" nameend="col5" align="right">900</entry></row></tbody></tgroup></table></tables>

The experiments shown below in Table III demonstrate that both bromobutyl and chlorobutyl rubber may effectively be employed in the process of this invention. In both cases, a mixture of 40 parts of polypropylene and 40 parts of SEBS were employed as a continuous phase. Dynamic vulcanization was effected using 2 parts of <b>DIAK 1</b> for bromobutyl and 5 parts <b>DIAK 1</b> for the chlorobutyl experiment. <tables id="tabl0003" num="0003"><table frame="all"><title>TABLE III</title><tgroup cols="6" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="26.25mm" /><colspec colnum="2" colname="col2" colwidth="26.25mm" /><colspec colnum="3" colname="col3" colwidth="26.25mm" /><colspec colnum="4" colname="col4" colwidth="26.25mm" /><colspec colnum="5" colname="col5" colwidth="26.25mm" /><colspec colnum="6" colname="col6" colwidth="26.25mm" /><thead valign="top"><row><entry namest="col1" nameend="col1" align="left"><u style="single">Experiment No.</u></entry><entry namest="col2" nameend="col2" align="center"><u style="single">Rubber 100 parts</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">Polyolefin, and TPE</u></entry><entry namest="col4" nameend="col4" align="center"><u style="single">Hardness, Shore A</u></entry><entry namest="col5" nameend="col5" align="center"><u style="single">Tensile, psi</u></entry><entry namest="col6" nameend="col6" align="center"><u style="single">Compression set</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="right">18</entry><entry namest="col2" nameend="col2" align="left">bromobutyl</entry><entry namest="col3" nameend="col3" align="right">80 parts</entry><entry namest="col4" nameend="col4" align="right">77</entry><entry namest="col5" nameend="col5" align="right">1700</entry><entry namest="col6" nameend="col6" align="right">31</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="right">19</entry><entry namest="col2" nameend="col2" align="left">chlorobutyl</entry><entry namest="col3" nameend="col3" align="right">80 parts</entry><entry namest="col4" nameend="col4" align="right">70</entry><entry namest="col5" nameend="col5" align="right">1100</entry><entry namest="col6" nameend="col6" align="right">51</entry></row></tbody></tgroup></table></tables>

As shown in Table IV below, in which the amount of hexamethylene diamine carbamate was varied. For bromobutyl rubber, a preferred range is 1.6 to 2.5 parts of the multifunctional amine such as shown in Table IV. <tables id="tabl0004" num="0004"><table frame="all"><title>TABLE IV</title><tgroup cols="5" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="31.50mm" /><colspec colnum="2" colname="col2" colwidth="31.50mm" /><colspec colnum="3" colname="col3" colwidth="31.50mm" /><colspec colnum="4" colname="col4" colwidth="31.50mm" /><colspec colnum="5" colname="col5" colwidth="31.50mm" /><thead valign="top"><row><entry namest="col1" nameend="col1" align="left"><u style="single">Experiment No.</u></entry><entry namest="col2" nameend="col2" align="center"><u style="single">DIAK 1 phr</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">Tensile psi</u></entry><entry namest="col4" nameend="col4" align="center"><u style="single">Compression set</u></entry><entry namest="col5" nameend="col5" align="center"><u style="single">Hardness Shore A</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="right">20</entry><entry namest="col2" nameend="col2" align="char" char=".">1.0</entry><entry namest="col3" nameend="col3" align="right">520</entry><entry namest="col4" nameend="col4" align="right">65</entry><entry namest="col5" nameend="col5" align="right">62</entry></row><row><entry namest="col1" nameend="col1" align="right">21</entry><entry namest="col2" nameend="col2" align="char" char=".">1.5</entry><entry namest="col3" nameend="col3" align="right">520</entry><entry namest="col4" nameend="col4" align="right">76</entry><entry namest="col5" nameend="col5" align="right">56</entry></row><row><entry namest="col1" nameend="col1" align="right">22</entry><entry namest="col2" nameend="col2" align="char" char=".">1.67</entry><entry namest="col3" nameend="col3" align="right">970</entry><entry namest="col4" nameend="col4" align="right">23</entry><entry namest="col5" nameend="col5" align="right">66</entry></row><row><entry namest="col1" nameend="col1" align="right">23</entry><entry namest="col2" nameend="col2" align="char" char=".">2.0</entry><entry namest="col3" nameend="col3" align="right">1250</entry><entry namest="col4" nameend="col4" align="right">22</entry><entry namest="col5" nameend="col5" align="right">70</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="right">24</entry><entry namest="col2" nameend="col2" align="char" char=".">2.2</entry><entry namest="col3" nameend="col3" align="right">1010</entry><entry namest="col4" nameend="col4" align="right">23</entry><entry namest="col5" nameend="col5" align="right">66</entry></row></tbody></tgroup></table></tables>

Shown below in Table V are experiments using 2 parts per 100 parts of rubber of 4 curing agents, except for experiment 28 which used 2.5 phr. <tables id="tabl0005" num="0005"><table frame="all"><title>TABLE V</title><tgroup cols="5" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="31.50mm" /><colspec colnum="2" colname="col2" colwidth="31.50mm" /><colspec colnum="3" colname="col3" colwidth="31.50mm" /><colspec colnum="4" colname="col4" colwidth="31.50mm" /><colspec colnum="5" colname="col5" colwidth="31.50mm" /><thead valign="top"><row><entry namest="col1" nameend="col1" align="left"><u style="single">Experiment No.</u></entry><entry namest="col2" nameend="col2" align="center"><u style="single">Curing agent at 2 phr</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">Tensile psi</u></entry><entry namest="col4" nameend="col4" align="center"><u style="single">Compression set</u></entry><entry namest="col5" nameend="col5" align="center"><u style="single">Hardness Shore A</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="right">25</entry><entry namest="col2" nameend="col2" align="left">DIAK 1</entry><entry namest="col3" nameend="col3" align="right">1700</entry><entry namest="col4" nameend="col4" align="right">31</entry><entry namest="col5" nameend="col5" align="right">77</entry></row><row><entry namest="col1" nameend="col1" align="right">26</entry><entry namest="col2" nameend="col2" align="left">DYTEK A</entry><entry namest="col3" nameend="col3" align="right">1400</entry><entry namest="col4" nameend="col4" align="right">37</entry><entry namest="col5" nameend="col5" align="right">74</entry></row><row><entry namest="col1" nameend="col1" align="right">27</entry><entry namest="col2" nameend="col2" align="left">Tetraethylene pentamine</entry><entry namest="col3" nameend="col3" align="right">1600</entry><entry namest="col4" nameend="col4" align="right">40</entry><entry namest="col5" nameend="col5" align="right">75</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="right">28</entry><entry namest="col2" nameend="col2" align="left">Polyethylene polyamine (2.5 phr)</entry><entry namest="col3" nameend="col3" align="right">1850</entry><entry namest="col4" nameend="col4" align="right">37</entry><entry namest="col5" nameend="col5" align="right">76</entry></row></tbody></tgroup></table></tables>

Finally, presented below in Table VI are various pharmaceutical properties and functionality of a preferred embodiment of the present invention which was shown in Experiment 1 in Table I. This product compares favorably with a standard commercially available butyl based thermoset product manufactured by The West Company. Thermosets, of course, cannot be reprocessed. <tables id="tabl0006" num="0006"><table frame="all"><title>TABLE VI</title><tgroup cols="3" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="52.50mm" /><colspec colnum="2" colname="col2" colwidth="52.50mm" /><colspec colnum="3" colname="col3" colwidth="52.50mm" /><thead valign="top"><row><entry namest="col1" nameend="col3" align="center">Pharmaceutical Closure Properties Comparison</entry></row><row><entry namest="col1" nameend="col1" /><entry namest="col2" nameend="col2" align="center"><u style="single">Invention</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">Standard</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="left">Compression set, %</entry><entry namest="col2" nameend="col2" align="right">25</entry><entry namest="col3" nameend="col3" align="right">13</entry></row><row><entry namest="col1" nameend="col1" align="left">Autoclave set, %</entry><entry namest="col2" nameend="col2" align="right">80</entry><entry namest="col3" nameend="col3" align="right">14</entry></row><row><entry namest="col1" nameend="col1" align="left">Moisture vapor transmission (g/m²/day)</entry><entry namest="col2" nameend="col2" align="right">0.4</entry><entry namest="col3" nameend="col3" align="right">0.65</entry></row><row><entry namest="col1" nameend="col1" align="left">Oxygen transmission (cc/m²/day)</entry><entry namest="col2" nameend="col2" align="right">287</entry><entry namest="col3" nameend="col3" align="right">214</entry></row><row><entry namest="col1" nameend="col1" align="left">pH shift</entry><entry namest="col2" nameend="col2" align="right">-0.3</entry><entry namest="col3" nameend="col3" align="right">-0.3</entry></row><row><entry namest="col1" nameend="col1" align="left">Turbidity (Nephelos units)</entry><entry namest="col2" nameend="col2" align="right">7.0</entry><entry namest="col3" nameend="col3" align="right">2.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Reducing agents (ml of 0.01 N I)</entry><entry namest="col2" nameend="col2" align="right">0.01</entry><entry namest="col3" nameend="col3" align="right">0.01</entry></row><row><entry namest="col1" nameend="col1" align="left">Total extractables (mg)</entry><entry namest="col2" nameend="col2" align="right">1.4</entry><entry namest="col3" nameend="col3" align="right">0.6</entry></row><row><entry namest="col1" nameend="col1" align="left">Heavy metals, ppm lead and zinc</entry><entry namest="col2" nameend="col2" align="right">0.0</entry><entry namest="col3" nameend="col3" align="right">0.0</entry></row><row><entry namest="col1" nameend="col1" align="left">Toxicity, acute systemic</entry><entry namest="col2" nameend="col2" align="right">non</entry><entry namest="col3" nameend="col3" align="right">non</entry></row><row><entry namest="col1" nameend="col1" align="left">Toxicity, intracutaneous</entry><entry namest="col2" nameend="col2" align="right">non</entry><entry namest="col3" nameend="col3" align="right">non</entry></row><row><entry namest="col1" nameend="col1" align="left">Toxicity, cytotoxicity</entry><entry namest="col2" nameend="col2" align="right">non</entry><entry namest="col3" nameend="col3" align="right">non</entry></row><row><entry namest="col1" nameend="col1" align="left">Coefficient of friction</entry><entry namest="col2" nameend="col2" align="right">47</entry><entry namest="col3" nameend="col3" align="right">65</entry></row><row><entry namest="col1" nameend="col1" align="left">Needle penetration, mg</entry><entry namest="col2" nameend="col2" align="right">364</entry><entry namest="col3" nameend="col3" align="right">342</entry></row><row><entry namest="col1" nameend="col1" align="left">Reseal</entry><entry namest="col2" nameend="col2" align="right">acceptable</entry><entry namest="col3" nameend="col3" align="right">acceptable</entry></row><row><entry namest="col1" nameend="col1" align="left">Freezer leaks</entry><entry namest="col2" nameend="col2" align="right">none</entry><entry namest="col3" nameend="col3" align="right">none</entry></row><row><entry namest="col1" nameend="col1" align="left">Vacuum retention, in Hg</entry><entry namest="col2" nameend="col2" align="right">21</entry><entry namest="col3" nameend="col3" align="right">21</entry></row><row><entry namest="col1" nameend="col1" align="left">Swelling, sesame oil, %</entry><entry namest="col2" nameend="col2" align="right">5</entry><entry namest="col3" nameend="col3" align="right">16</entry></row><row><entry namest="col1" nameend="col1" align="left">Swelling, cotton oil, %</entry><entry namest="col2" nameend="col2" align="right">5</entry><entry namest="col3" nameend="col3" align="right">10</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="left">Swelling, mineral oil, %</entry><entry namest="col2" nameend="col2" align="right">91</entry><entry namest="col3" nameend="col3" align="right">82</entry></row></tbody></tgroup></table></tables>

Presented in Table VII are additional experiments on which other thermoplastic elastomeric block copolymers having terminal polystyrene units are shown to be very effective embodiments of the present invention. Both SBS and SIS demonstrated effectiveness in preparations which are useful thermoplastic elastomer composition. All of these products had 100 parts of bromobutyl rubber and 2 parts of <b>DIAK 1</b> curing agent. <tables id="tabl0007" num="0007"><table frame="all"><title>TABLE VII</title><tgroup cols="7" colsep="1" rowsep="0"><colspec colnum="1" colname="col1" colwidth="22.50mm" /><colspec colnum="2" colname="col2" colwidth="22.50mm" /><colspec colnum="3" colname="col3" colwidth="22.50mm" /><colspec colnum="4" colname="col4" colwidth="22.50mm" /><colspec colnum="5" colname="col5" colwidth="22.50mm" /><colspec colnum="6" colname="col6" colwidth="22.50mm" /><colspec colnum="7" colname="col7" colwidth="22.50mm" /><thead valign="top"><row><entry namest="col1" nameend="col1" align="left"><u style="single">Experiment No.</u></entry><entry namest="col2" nameend="col2" align="center"><u style="single">Polypropylene phr</u></entry><entry namest="col3" nameend="col3" align="center"><u style="single">TPE phr</u></entry><entry namest="col4" nameend="col4" align="center"><u style="single">Compression set</u></entry><entry namest="col5" nameend="col5" align="center"><u style="single">100% modulus psi</u></entry><entry namest="col6" nameend="col6" align="center"><u style="single">Tensile psi</u></entry><entry namest="col7" nameend="col7" align="center"><u style="single">Hardness Shore A</u></entry></row></thead><tbody valign="top"><row><entry namest="col1" nameend="col1" align="right">29</entry><entry namest="col2" nameend="col2" align="right">40</entry><entry namest="col3" nameend="col3" align="left">SBS, 40</entry><entry namest="col4" nameend="col4" align="right">56</entry><entry namest="col5" nameend="col5" align="right">570</entry><entry namest="col6" nameend="col6" align="right">1400</entry><entry namest="col7" nameend="col7" align="right">75</entry></row><row rowsep="1"><entry namest="col1" nameend="col1" align="right">30</entry><entry namest="col2" nameend="col2" align="right">40</entry><entry namest="col3" nameend="col3" align="left">SIS, 40</entry><entry namest="col4" nameend="col4" align="right">59</entry><entry namest="col5" nameend="col5" align="right">590</entry><entry namest="col6" nameend="col6" align="right">1360</entry><entry namest="col7" nameend="col7" align="right">75</entry></row></tbody></tgroup></table></tables>

As can be seen, a variety of useful compositions can be prepared according to to the present invention, particularly for use in the pharmaceutical industry. The above formulations have been made into pharmaceutical products such as vial stoppers, blood tube stoppers, dropper bulbs, syringe tips and the like.