Device for the biofeedback control of body parameters.

p0001The invention relates to a device for biofeedback control of bodily functions according to the preamble of the main claim.

p0002From DE-OS 36 04 986 a device for preventing oxygen deficiency damage and to correct breathing disorders is known having breathing or with the tissue oxygenation standing associated sensors. If detected by the sensors values ​​predetermined threshold values ​​exceed or fall. below, switching devices are driven, proposed for the respiratory stimuli by blowing the patient with a special breathing gas mixture or Atemweckreize.

p0003The invention is based on the object to provide a device according to the preamble of the main claim, which allows continuous monitoring of biological body functions or therapy of a patient with automatic drug delivery.

p0004This object is achieved by the characterizing features of the main claim.

p0005By providing a treatment device with at least a pump for intravenous, intra-arterial, oral or intraluminal application and one associated with the pump drug reservoir, the pump being driven as a function of predetermined therapy targets for the body functions and predetermined drug dosage depending on the measured values ​​and the drug to the desired application site promotes and wherein the sensor is the possibly occurring effect of the drug continuously detected and made in accordance with the effect of a change in the actuation of the pump, an accurate, continuous and effective therapy of various biological functions of the body can be performed.

p0006The measures indicated in the dependent claims, advantageous developments and improvements are possible.

p0007An embodiment of the invention is illustrated in the drawing and is explained in more detail in the following description. The single figure shows a block diagram of the inventive device.

p0008The apparatus shown in figure 1 for the biofeedback control has a sensor arrangement, which consists of one or more sensors being provided in the drawing, a pH sensor 1, a pressure sensor 2 and a temperature sensor 3rd Of course, other sensors can be connected, for example, those that measure the pulse, respiratory rate, potential differences or biochemical parameters. The sensors 1, 2, 3 are associated with amplifiers 4, 5, 6, which are connected to a multiplexer 7, which is connected via an A / D converter 8 and directly with a microcomputer. 9 Furthermore, one or more data memory 10 are provided, which store the measured values ​​from the sensors and comparing and contain limits. The microcomputer 9 includes a keypad 11 and is provided with an alphanumeric and / or graphic display 12 and an alphanumeric and / or graphic printer 13 connected. Furthermore, it is provided with an interface 14 for data transfer and controls a visual and / or audible alarm device 15 on.

p0009In addition to the measuring and evaluating device 1 to 15 indicated in the upper part of the figure, a therapy device is provided, the at least one of a further microprocessor 16 driven pump, in the illustrated embodiment, there are two peristaltic pumps 17, 18, which the drugs to promote intravenous or intra-arterial and oral or intraluminal application. Each pump 17, 18 is a drug reservoir in the form of slots 19,20 associated with that contains the corresponding via the sensors 1,2,3 and the microcomputer 9 started diagnosis medication to be administered, wherein the drug reservoir to a hose 21 19.20 is 22 is connected, which is guided through the pump 17,18 to the patient. The insertion of each drug reservoirs 19,20 is provided with an identification code that is from a scanner 23.24, for example, an optoelectronic or magnetic pickup or the like, is detected. At the slots of the drug reservoirs 19,20 and level sensors can be arranged, which registers the respective fill level of the medicament in the slots. Instead of the level sensors or in addition to them, the level and the microprocessor 16 can be determined, knowing the initial quantity of the drug and each dose administered via the pump 17.18.

p0010The pumps 17,18 and 23,24 sampler are connected to both the microcomputer 16 and a monitoring unit 25 which receives information from the microcomputers 9.16 and the required redundancy ensures. The monitoring unit preferably has its own microprocessor, are said to live decisive parameters such as the intra-arterial pressure, a second sensor arrangement with measurement analysis unit and comparison unit, which are realized by the microprocessor provided. The measured from the main measured and -auswerteanordnung 1-9 values ​​are continuously checked. When occurring differences that make a failure of one of the two systems likely a visual and audible alarm pulse is achieved. For non-vital parameters, such as temperature or pH, a plausibility program contained in the internal microprocessor, which takes over the monitoring of the main program. Also for the treatment means are suitable peripherals such as display unit 26, keyboard 27 and visual and / or audible alarm unit 28 are provided which are connected to the microprocessor 16 and to the monitoring unit 25th

p0011Naturally, the microcomputer can be 9, 16 are combined into a single unit, then only a keypad, a display unit and an alarm device are necessary.

p0012In addition to the power supply via power, the inventive device to a power supply 29 by batteries or accumulators, the operation maintains at power failure for a long time (6 to 8 hours).

p0013The function of the device according to the invention is the following:

p0014The measured with the sensors 1, 2, 3 via defined time ranges, values ​​of the biological body sizes of the patient are stored in the memory 10 or in another memory of the microcomputer 9 and, where appropriate, for example, converted by calculation to determine the mean values, median values ​​or the like. The measured values ​​are compared with fixed reference values ​​or with input from the doctor on the keypad 11 comparison values ​​and interpreted in accordance with a stored in the microcomputer 9 Diagnostics.

p0015In the microcomputer 9 and 16 treatment goals, drug-highest doses, doses stored on specific time ranges and type of drug administration. Depending on the determined measurement values ​​by means of the diagnosis, the therapy device is activated, ie, the microcomputer 16 controls one or more pumps 17, 18, wherein either stimulatory or inhibitory drugs can be administered. the respective drug is identified prior to activation with the aid of the identification code detected scanner 23, 24, so that the erroneous infusion false drugs is not possible. The microcomputer 16, the pumps 17, 18 drive in such a way that the drug be administered continuously, pulsatile or bolus-wise, and a combination of pulsatile administration or continuous administration of bolus doses is possible.

p0016Parallel to the drug administration the interesting biological body sizes on the sensors 1, 2, 3 continue to be measured, so that the success of the therapy monitored continuously and optionally changed the Medikamentendarreichung or terminated or a different drug can be given.

p0017Depending on the use of the device, the dosage levels, for example, predefined steps or calculated by microcomputer doses within the maximum daily amounts and the maximum amounts per short unit time, device-specific hard-coded for general users or are for example freely programmable for research for all bodily functions. The display units 12, 26 allow the display of all data and functions and provide information about the entire treatment of data and information therapy functions. Accordingly, all data can be printed on the printer. 13

p0018The alarm devices 15, 28 emit optical and / or audible alarms when the functions of the individual components of the device, the information of the drug reservoir, the diagnosis values ​​or therapeutic goals do not match the predetermined or desired values.

p0019In the following are given two examples of the inventive device, namely is, first, a gastric pH control of synergistic therapeutic functions in DC circuit of the pump functions of the pump 17, 18 and secondly, a blood pressure control antagonistic therapy functions in counter circuit of the pump functions are performed.

p00201. gastric pH Control: The pH-sensor 1 measures intraluminal the H + ion activity, the measured data are stored and verglichen.Zur with the values ​​stored in the microprocessor adjusting the therapy target, for example, raising the pH value, the microprocessor activates 16 the first pump with a standard drug, for example, H2-antagonist or ATP-ase inhibitors, either as a "primed infusion", ie, a bolus followed by a continuous infusion or as a pulsatile infusion. The applied from the pump Standard Doses is the comparative therapeutic goal / success increased or gradually reduced accordingly. The temporal adjustment and definition of treatment success / -mißerfolges be predetermined. If missing the target therapy despite maximum dose is either an alarm or activate the second pump with a combination preparation. The treatment steps with the second

p0021Pump made in accordance with those in the first pump.

p00222. Blood Pressure: Two or three independent pressure sensors measure the intra-arterial pressure, which is compared with the target pressure over defined periods of time. The adjustment of the current pressure to the target pressure is carried out with extremely controllable medications, said the first pump associated drugs increase the pressure and the second pump associated drugs can reduce the pressure. The system can be equipped with one or two additional, downstream pumps that can apply additional synergistic or antagonistic drugs. The sensor functions are continuously monitored by the instrument and the measurement data of two or three sensors are compared with each other. In the event of deviations which are greater than a predetermined value, an alarm is triggered and the control of the pump is stopped.