Active substance for treating alterations of the skin and the mucous membranes.

p0001The invention assumes that occurs as a result of a change in the metabolism of most diseases. These metabolic changes are determine to a large extent differences in the field of trace elements. It is well known that a lack of trace elements causing specific deficiencies. Oversupply also triggers atypical disorders.

p0002For the treatment of metabolic disorders such as exist in Schwermetallintoxikationen or arteriosclerosis and related diseases, have polyamino, particularly ethylenediaminetetraacetic acid (EDTA) proven (BW Halstead "The Scientific Basis of EDTA Chelation Therapy" Golden Quill Publ. Inc., Colton 1979 pages 21 to 27).

p0003The complexing action of polyhydroxycarboxylic and their salts, such as the D-gluconates, one uses in the calcium therapy and for providing bioavailable iron in toning agents from (pharmaceutical substance list, eds. ABDA, Frankfurt / Main "gluconic" P. 84 to 87).

p0004Fruit acids, citric insbesonder previously found application in pharmaceuticals as acidifiers in effervescent tablets, taste modifier, Desinfizienz and stomach acid substitution (pharmaceutical substance list, Edit .: ABDA, Frankfurt / Main "citric" p 86 to 89).

p0005In DE-OS 16 17 607, mixtures of heavy metal salts, input and polybasic Di-nitrilo-R-carboxylic acids and R-oxy-R-carboxylic acids indicated that have physiological effects on rheumatism, viral infections and promote wound healing.

p0006these groups of substances have been used so far neither alone nor in combination for the treatment of the consequences of metabolic disorders in the skin, mucous membranes and skin appendages.

p0007It has now surprisingly been found that, as described in the claims, by a combination of salts or derivatives of fruit acids with salts complex-forming organic acids such as of aminopolycarboxylic acids and / or their salts and / or their derivatives or of a salt and / or derivative of gluconic can influence the consequences of metabolic and tissue diseases of skin, mucous membranes and skin appendages positive.

p0008Thus excess supply can be eliminated by complexing salts or can be brought into a form which allows for better or easier distribution at a lower supply.

p0009The claimed formulations showed a surprisingly wide spectrum of action. For all diseases described below occurred in a very short time a relief or cure. As very much must be emphasized that the formulations are not toxic and do not show any side effects.

p0010The active substance of the invention was used in various skin and mucosal changes:<ul><li>1. Presentation by<ul><li>a) <u>bacteria</u> eg folliculitis, boils</li><li>b) <u>viruses</u> for example herpes simplex, varicella, aphthous</li><li>c) <u>microbes</u> eg stomatitis, periodontitis</li><li>d) <u>mushrooms</u> eg intertrigo</li></ul></li><li>2. diseases caused by physical or chemical noxae eg hyperkeratosis, mechanical skin damage (eg scars)</li><li>3. Diseases caused by exogenous or endogenous allergens eg cheilitis, contact dermatitis due to plants, metals or drugs, psoriatic group, eczema, lichen planus</li><li>4. Diseases caused by metabolic disorders (including toxic) eg acne vulgaris, eczema seborroicum, hyperhidrosis</li><li>5. Diseases caused by endocrine disorders eg periodontal disease, fibrosis There is evidence that the agents may also have a cytostatic effect (see FIG. 5)</li><li>7. A cosmetic skin treatment.</li></ul>

application examples

p0011<ul><li>1. With a solution consisting of: 20% ammonium citrate 10% sodium gluconate 5% sodium lactate 65% H₂O Subjects were treated. The solution was applied with cotton swabs.<ul><li>A) <u>Diagnosis:</u> Allergic eczema on both hands Therapy: a) cortisone preparations - no improvement b) solution claimed - skin lesions healed within 6 days</li><li>B) <u>Diagnosis:</u> Psoriasis all over the body (histologically proven in Dermatology) After 15 weeks of inventive treatment lesion healed; Itching removed after 3 days.</li><li>C) <u>Diagnosis:</u> Acne vulgaris (for 7 years) Rouge By treating with an inventive solution after 2 weeks</li></ul></li><li>2. Using a solution consisting of: 20% ammonium citrate 10% (Ethylendinitrilotetraessigasäure disodium) dihydrate 5% sodium lactate 65% H₂O Subjects were treated in the same manner. The healing effect was congruent with the Example 1. In some cases, the substance mixture was applied as a gel, in order to achieve better adherence to the treatment sites. To this end, the solution was placed in ointment consistency with highly disperse silica. It was observed in the treated subjects a strong tightening of the upper parts of the skin, so that it can be assumed that this preparation is to be used as a cosmetic.</li><li>3. solution consisting of 10% by weight citric acid 5 wt% ethylenediaminetetraacetic 85 wt% H₂O pH adjusted to 9 with KOH. With this solution, 6 subjects were treated. <u>Diagnosis:</u> seborrheic dermatitis <u>Therapy:</u> The affected areas were 2 - 3 times a day easily rubbed.. Skin lesions healed after 8 days.</li><li>4. solution consisting of: 0.1% by weight citric acid 0.5 wt% (ethylenediaminetetraacetic acid disodium salt) dihydrate 99.4 wt% H₂O pH adjusted to 5.2 with NaOH. With this solution, 3 subjects (infants) were treated. <u>Diagnosis:</u> neurodermatitis <u>Therapy:</u> The affected areas were slightly daily rubbed with the solution 3 times. Relief of typical itching after 8 hours. Healing after 12 days.</li><li>5. solution consisting of: 10% by weight malic acid 5% by weight (ethylenediaminetetraacetic acid disodium salt) dihydrate 85 wt% H₂O pH was adjusted with ammonia to 5.2. With this solution, 10 subjects were treated. <u>Diagnosis:</u> gingivitis simplex <u>Therapy:</u> Brush the affected areas. Already after the first treatment, a decay of the inflammatory symptoms was observed. Healing in 2 times a day. Application after about 7 days.</li><li>6. A solution consisting of: 10% by weight potassium citrate 3% by weight cyclohexylene (1,2) -dinitrilotetraessigsäure (monohydrate) 87 wt% H₂O was placed in ointment consistency means highly disperse silica. This ointment 4 subjects were treated.<u>Diagnosis:</u> Heavily exuding and itchy eczema <u>Therapy:</u> 2 times a day. Applying the ointment. Skin changes depending on the severity after 4 - 9 weeks abgheilt.</li><li>7. A solution consisting of: 20% by weight potassium citrate 5 wt% diethylenetriaminepentaacetic acid, 3-aza-3- (carboxymethyl) pentamethylendinitrilotetraessigsäure 75 wt% H₂O was placed in ointment consistency with highly disperse silica. This ointment subject was enrolled. <u>Diagnosis:</u> Wasp sting with local infection, allergic skin reaction and swelling of the left lower leg lateral. <u>Therapy:</u> 2 times a day. Applying the ointment. Itching after 10 minutes. Decayed. After 3 days the entire allergic skin reaction had subsided and healed the local infection at the injection site. After discontinuation of the ointment no recurrence.</li><li>8. A reading consisting of: 5% by weight potassium citrate 0.1 wt% of bis (aminoethyl) glycol ethers-N, N, N ', N'-tetraacetic acid (3.6 Dioxaoctamethylen-dinitrilo-tetraacetic acid) 94.9 wt% H₂O was brought to salve consistency with talc. This ointment 4 patients were treated. <u>Diagnosis:</u> Strong contact allergy <u>Therapy:</u> 1 -. 2 times daily application of ointment to the affected areas. Skin lesions after 4 - 6 days healed.</li><li>9. Using a solution consisting of: 10% by weight ammonium citrate 5% by weight sodium gluconate 85 wt% H₂O were treated 9 subjects: <u>Diagnosis:</u> tonsillitis <u>Therapy:</u> The initial solution was developed by the subjects themselves with tap water to 1: 1 - 1: 4 diluted and 3 - 4 times a day gargled.. After 2 - 3 days, the subjects were free of symptoms.</li><li>10. With a solution of: 20% by weight ammonium citrate 10% by weight ethylenediaminetetraacetic acid disodium salt - dihydrate 70 wt% W / O emulsion 3 treated subjects. <u>Diagnosis:</u> rosacea <u>Therapy:</u> 2 times daily application of the emulsion. After 4 days there is a clear decline in the lesions. After treatment for 4 weeks and discontinuation of ointment no recurrence.</li><li>11. With a solution consisting of: 20% by weight ammonium citrate 10 wt% (ethylenediaminetetraacetic acid disodium salt) - dihydrate 70 wt% H₂O treated 32 subjects. <u>Diagnosis:</u> Strong periodontitis <u>Therapy:</u> was administered by 2 - 3 times a day applying with cotton swabs.. Healing, after 10 - 14 days depending on the severity of the phenomenon.</li><li>12. solution consisting of: 20% by weight ammonium citrate 10 wt% (ethylenediaminetetraacetic acid disodium salt) - dihydrate 70 wt% H₂O This solution was adjusted by means of highly disperse silica in ointment consistency. It dealt herewith 8 subjects. <u>Diagnosis:</u> Lichen Planus <u>Therapy:</u> The parts to be treated, 1 - 2 times daily with the ointment pocketed.. Significant improvement already after the 3rd treatment. Recovery without relapse after about 4 months.</li><li>13 solution consisting of: 3% by weight ammonium tartrate 3% by weight (ethylenediaminetetraacetic acid disodium salt) dihydrate 94 wt% H₂O With this solution, 1 subject was enrolled. <u>Diagnosis:</u> herpes simplex <u>Therapy:</u> was applied 2 - 3 times a day with cotton swabs.. In all cases, healing after 3 - 4 days.</li><li>14 solution consisting of: 0.1% by weight of nitrilotriacetic acid 0.2 wt% of fumaric acid disodium salt 50.0 wt% ethyl alcohol 49.7 wt% H₂O This solution was adjusted by means of highly disperse silica in ointment consistency. were treated 11 subjects. <u>Diagnosis:</u> contact dermatitis <u>Therapy:</u> By rubbing the affected areas decrease in lesions after about 8-12 hrs .; Healing after 3 - 4 days.</li></ul>