Nova Patents
EP0321094A3

Treatment of factor viii inhibitors

Abstract

Fragments of human Factor VIII:C which bind to antibody inhibitors of Factor VIII in patients afflicted with such inhibitors are disclosed. The method of treating Factor VIII inhibitors, by administering one or more of these fragments, is also disclosed.

Term

Term ended

Projected expiry passed 16 November 2008, 17.9 years ago.

  1. Priority
  2. Filed
  3. Published
  4. Projected expiry
  5. Today

Every citation, both waysCites: the store holds 2 of 3

Citations
DocumentRelationOfficeCited during
EP0202853A2CitesEuropean Patent Office (EPO)Search report
WO8602838A1CitesWorld Intellectual Property Organization (WIPO)Search report
The Journal of Biological Chemistry, Vol. 261, No. 27, 25th September 1966, pages 12574-12578, American Society of Biological Chemists, Inc., US; R.L. BURKE et al.: "The functional domains of coagulation factor VIII:C", page 12576, figure 1.Non-patent–Search report
Proceedings of the National Academy of Sciences, USA, Vol. 82, November 1985, pages 7728-7732; C.A. FULCHER et al.: "Localization of human factor FVIII inhibitor epitopes to two polypeptide fragments", front page, Abstract; pages 7731-7732: "Discussion".Non-patent–Search report
Biochemistry, Vol. 25, No. 2, January 1986, pages 505-512, American Chemical Society, Washington, US; D. EATON et al.: "Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity", page 511, figure 8; page 511, column 1, lines 15-19.Non-patent–Search report
Nature, Vol. 312, No. 5992, November-December 1984, pages 337-342, London, GB; G.A. VEHAR et al.: "Structure of human factor VIII", page 339, figure 3.Non-patent–Search report