Methods of and apparatus for generating low frequency electrical stimulus signals.

The present invention relates to methods of and apparatus for generating low frequency electrical stimulus signals, which signals may be used to provide an electrical stimulus to a biological body.

It has been proposed that, when audible stimulus is given to a biological body by, for example, playing suitable music such as light or classical music, curative effects for pain such as shoulder discomfort or for other unpleasant feelings can be achieved since the biological body feels pleasant or unpleasant based upon the experimental conception, or its attention is forcibly concentrated on to matters other than pain and unpleasant feelings. Similarly, it is also known that when an electrical stimulus (such as skin or percutaneous stimulus) is given to a biological body, pain, shoulder discomfort or other unpleasant feelings can be relaxed or cured.

According to experimental ideas, it has also been proposed that a biological body can feel increased refresh stimulus, which can achieve higher curative effects, when a relatively frequent stimulus is given to the biological body rather than a stimulus which is provided at a lower rate, and also that a stimulus regularly given to the biological body is better than an irregular stimulus.

Based upon the above-described observations and proposals, various curing methods have been proposed to reduce pain.

As one example of an electrical stimulus signal generating technique, there has been proposed a method of producing an electrical stimulus signal, the pulse repetition frequency of which is not varied in accordance with a lapse in time, and for giving such a stimulus signal to a biological body, in particular to sympathetic nerves and parasympathetic nerves. Moreover, an electrical stimulus signal generating apparatus has been proposed, for example, In Japanese Patent Publication No. 56-5543 (hereinafter referred to as "the first reference") and Japanese Utility Model Publication No.56-22921 (hereinafter referred to as "the second reference").

The first reference describes a technique in accordance with the so-­called l/f fluctuation theory, in which a musical signal is analyzed as a frequency spectrum, the power spectrum density of the analyzed signal being inversely proportional to the frequency, while the frequency of the electrical stimulus signal is changed over a relatively long time period from 0.5 to 4 seconds within a frequency range between 10 and 100 Hz, and an electrical stimulus signal is thereby produced.

On the other hand, the second reference describes a technique in which the pulse repetition frequency of the electrical stimulus signal and also an irregular pulse pattern (in which the generating duration time of the same pulse repetition is varied) are previously recorded on a recording medium, and the reproduction of the recorded data from the recording medium is performed in accordance with the l/f fluctuation theory.

Since, as has been found in this field, when the tempo of music is synchronized with the nerves and further with tissue and cells, the effects of pain reduction can be enhanced. Accordingly, this effect can be realized in that, if the sound volume level (or sound pressure level) is used as sound information, the percutaneous stimulus can be given to a biological body in synchronism with the tempo of the music.

However, since according to the above-described technique, the percutaneous stimulus is given to a biological body in accordance with the frequency as derived by the l/f fluctuation theory, it is practically difficult to fit this stimulus with the tempo of the music.

Moreover, it is known in this field that when an audible stimulus such as music or other sounds and a percutaneous stimulus (electrical stimulus) reflecting the audible information are combined and provided to a biological body, a greater curative effect in reducing pain can be expected as compared with a single stimulus. The curative effect may be furthermore emphasized when both the audible stimulus and the electrical stimulus are provided to the biological body in substantially real time.

However, according to the above-described techniques, neither method can provide both stimuli to a biological body in real time. Accordingly, since the electrical stimulus is given to a biological body even when the music is under a rest condition or muted, thereby providing lower sound pressure, this stimulus is not matched with the experimental pain reduction of a biological body. As a result, the biological body experiences this stimulus as continuous variation of mere stimulus patterns, so that no significantly-increased curative effects can be expected to lead to reduced pain.

According to a first aspect of the present invention there is provided a method of generating a low frequency electrical stimulus signal, characterized in that, to generate the electrical stimulus signal to give electrical stimulus to a biological body, either current control or voltage control or both current and voltage control is performed in accordance with sound volume levels supplied from a sound source to modulate said electrical stimulus signal, and said electrical stimulus signal is arranged to be at a low frequency.

The sound volume level is preferably sampled at the rate at which the biological body senses it in substantially real time, the respective sound levels obtained by the sampling are converted into frequencies within a low frequency region, and then the current or voltage frequency modulation is performed by these frequencies so as to control the current or voltage.

In this case, the low frequency range of the sound volume level-to-­frequency conversion is preferably selected to be between 0 and 60 Hz.

The sound volume level may be sampled at a predetermined rate at which the biological body senses it in substantially real time, whereupon the respective sound volume levels acquired by this sampling operation are converted into amplitude control values corresponding thereto, and finally the amplitude modulation is carried out in accordance with these amplitude control values within a range of 0 to 100% of the voltage or current initial setting amplitude value, so as to control the current or voltage.

In addition, the sound volume level may be sampled at a predetermined rate at which the biological body senses it in substantially real time, the respective sound levels obtained by this sampling operation are then converted into pulse number control values, and finally pulse number modulation is carried out in accordance with these pulse number control values so as to effect the current or voltage control.

In the preferred embodiment, the pulse number modulation is performed in such a manner that the pulse number is within a range from 0 to 30 in response to the second volume level. Moreover, the above-­described sampling operation may be performed in a period from 0.01 to 0.5 seconds.

According to a second aspect of the present invention there is provided low frequency electrical stimulus signal generating apparatus for applying an electrical stimulus to a biological body, the apparatus comprising: a control section wherein a sound volume level derived from a sound source is samples at a rate at which the biological body can sense it in substantially real time, the respective samples sound levels are converted into frequencies corresponding to low frequencies and output, as well as predetermined control information; and a current and/or voltage controlling section wherein current and/or voltage stimulus signals are frequency-modulated separately based upon said frequencies, said control section and current and/or voltage controlling section being included ina stimulus signal generating section.

The stimulus generating section preferably includes a control system selecting section for switching only one of the current and voltage stimulus signals based upon control information derived from the control section and for ouputting the same as the electrical stimulus signal.

Moreover, the current control section may include a waveform generating section for outputting a voltage waveform signal corresponding to the sound volume levels, and a current stimulus signal generating circuit for outputting a current stimulus signal having the same waveform as that of an input voltage waveform signal.

In addition, the control section may include a waveform generating section for generating a voltage waveform signal having a frequency corresponding to the sound volume level, and a voltage stimulus signal generating circuit for outputting the input voltage waveform signal as a voltage stimulus signal.

Furthermore, the low frequencies are preferably within a region between 0 and 60 Hz.

Moreover, the sampling period is preferably selected to be 0.01 to 0.5 seconds.

In the preferred embodiment, the control section includes means for subdividing the second volume levels into a plurality of level steps, a read-­only-memory for previously storing a sound volume level-to-frequency conversion table, and means for reeading out from the read-only-memory a frequency corresponding to the second volume level at each sampling opeation.

In the preferred embodiment, the sound volume level is set to a zero level of the sound volume level when the sound volume level is equal to a zero or lower level.

In accordance with preferred features of the first and second aspects of the invention, the current or voltage controlling is performed based upon the sound pressure level of the sound information, so as to modulate the electrical stimulus signal in an irregular manner. Accordingly, a biological body can be stimulated by electrical stimulus in response to the tempo of the sound information. Also, no stimulus time period can be made with the hearing stimulus when the music is in a rest or muted condition, or the sound volume level is low. As a result, percutaneous stimulus is given to the biological body at the timing at whicht eh biological body senses in substantially real time, and thus the curing effects of a musical cure using this technique can be improved as compared with the previously-proposed curing effects.

According to the preferred embodiments, since the sound pressure sampling is performed with a shorter cycle by which the biological body feels in substantially real time, the electrical stimulus can be modulated in substantially real time with the hearing stimulus, so that unpleasant feelings are removed and the curative effects to reduce pain can also be improved.

In addition, the frequency of the electric stimulus signal is selected to be a low frequency, for instance between 0 and 60 Hz, so that the mental and physical reactions of a biological body can be relaxed by a pulling phenomenon against the natural vibration of automatic nerve reaction (for instance, in the so-called phenomena of "KEDACHI (goose flesh)" and "FURUE (tremble)" in order to provide a relaxed feeling to the biological body, the natural vibration of which is approximately 15 Hz.

According to a third aspect of the present invention there is provided a method of generating a low frequency electrical stimulus signal for applying the signal to a biological body, characterized in that, in response to a waveform of sound information derived from a sound source, at least one of current control and voltage control is performed to rhythm-modulate said electrical stimulus signal, and said electrical stimulus signal is arranged to be a low frequency.

In the preferred embodiment, a judgement is first made whether or not sound information is present. If this sound information is present, only low frequency information having a frequency lower than approximately 200 Hz is derived.

As a result of the detection, when no sound information is detected, quasi-sound information having an arbitrary waveform is generated from a rhythm generator which may be provided independently. The current or voltage control is performed by utilizing the respective waveforms of the low frequency sound information and quasi-sound information.

In accordance with the preferred embodiment, it is preferable that the intensity of the electrical stimulus signal is selectively adjustable based upon the information supplied from the external source.

According to a fourth aspect of the present invention there is provided low frequency electrical stimulus signal generating apparatus comprising: an input section for setting conditions and for adjusting the same; and a stimulus signal generating section, said stimulus signal generating section including: a waveform control section for outputting a rhythm-modulated waveform signal by deriving low frequency sound information from a sound source; a current control section for generating a current stimulus signal based upon the rhythm-modulated waveform signal; a voltage control section for generating a voltage stimulus signal based upon the rhythm-modulated waveform signal; a control system selecting section for outputting at least one of the current stimulus signal and the voltage stimulus signal as the electrical stimulus signal; and a control section for controlling operation of the aforementioned sections and selection based upon a signal derived from the input section.

The waveform control section preferably includes a comparator for detecting whether or not sound information is present, a low pass filter for filtering low frequency sound information only having a frequency lower than approximately 200 Hz, a rhythm generator for generating quasi-sound information, and a selection switch for selecting the low frequency sound information when sound information is input, and the quasi-sound information when sound information is not input.

In the preferred embodiment, the current control section includes an intensity setting circuit of the rhythm-modulation waveform signal, and a current stimulus signal generating circuit for outputting a current stimulus signal having the same waveform as that of a waveform input from the intensity setting circuit, and further the voltage control section includes a voltage stimulus circuit for outputting a voltage stimulus signal by adjusting the rhythm-modulated waveform signal.

In the preferred embodiment, the intensity of the electrical stimulus signal is selectively adjustable.

Either current control or voltage control may ber performed based upon the waveform of the sound information so as to modulate the electric stimulus signal in an irregular manner. As a result, the biological body can be electrically stimulated, in other words, a percutaneous stimulus can be provided in accordance with the tempo of the music or the like. When there is no sound information, the biological body can be stimulated by the waveforms of the quasi-sound information which has been generated. Consequently, since the biological body can be stimulated with the percutaneous stimulus at the rate at which it can be sensed in substantially real time, reduction in pain and curative effects can be further improved, as compared with the previously-proposed musical medical treatments.

Furthermore, since only the sound information is utilized which contains low frequencies (lower than about 200 Hz) typically of the bass and drum, unpleasant feelings can be effectively eliminated.

According to a fifth aspect of the present invention there is provided low frequency electrical stimulus signal generating apparatus comprising a stimulus signal generating section which includes: a control section in which sound volume levels supplied from a sound source are samples at a rate at which a biological body senses it in substantially real time, each of the sampled volume levels is converted into a corresponding amplitude control value and the resultant value is output, and predetermined control information is output; and a current/voltage control section for performing amplitude modulation in response to the amplitude control value within a range of 0 to 100% of an initial set amplitude value of current and/or voltage stimulus signals.

The stimulus signal generating section preferably includes a control system selecting section for switching only one of the current and voltage stimulus signals based upon control information derived from the control section and for outputting the same as the electrical stimulus signal.

In the preferred embodiment, the current control section includes a waveform generating section for outputting a voltage waveform having an arbitrary frequency, an intensity setting circuit for controlling the intensity of the voltage waveform signal by the amplitude control value, and a current stimulus signal generating circuit for outputting a current stimulus signal having the same waveform as that of the voltage waveform signal input from the intensity setting circuit.

In the preferred embodiment, the voltage control section includes a waveform generating section for outputting a voltage waveform signal having an arbitrary frequency, and a voltage stimulus signal generating circuit for controlling the intensity of the input voltage waveform signal based upon the amplitude control value and for ouputting the same as a voltage stimulus signal.

In the preferred embodiment, the frequency is selected to be from 0 to 60 Hz, and the sampling operation is performed within a time period from 0.01 to 0.5 seconds.

Furthermore, in the preferred embodiment, the control section includes means for subdividing the sound volume levels into a plurality of level steps, and means for converting the subdivided levels into the corresponding amplitude control values and for outputting the converted control values.

Moreover, in the preferred embodiment, an electrical stimulus signal having 24 steps is obtained as the amplitude control value within a range between 0 and 100% of the initial setting intensity.

The current or voltage controlling may be performed based upon the sound pressure level of the sound information so as to modulate the electrical stimulus signal in an irregular manner. Accordingly, the biological body can be stimulated by electrical stimulus in response to the tempo of the sound information. Also, no stimulus time period can be made with the hearing stimulus when the music is in a rest or muted condition, or the sound volume level is low. As a result, percutaneous stimulus is given to the biological body at the timing at which the biological body senses in substantially real time, and thus the curing effects can be improved as comapred with the previously-proposed curing effects.

According to the preferred embodiments, since the sound pressure sampling is performed with a shorter cycle by which the biological body feels in substantially real time, the electrical stimulus can be modulated in substantially real time with the hearing stimulus, so that unpleasant feelings are removed and the curative effects for reducing pain can also be improved.

In addition, the frequency of the electrical stimulus signal may be selected to be a low frequency, for instance, 0 to 60 Hz, so that the mental and physical reactions of the biological body can be relaxed, as explained above.

According to a sixth aspect of the present invention there is provided a method of generating a low frequency electrical stimulus signal, characterized in that, to generate an electrical stimulus signal to be provided to a biological body, control information previously stored in a control section is read out without using acoustic information from a sound source so as to control current and voltage stimulus signals, and said current and voltage stimulus signals are alternately output as the electrical stimulus.

The control information is preferably selected from more than one sort of waveform, frequency and intensity information. The control information may be selectable and variable to appropriate values suitable for the biological body in response to external input.

Moreover, the alternating operations of the current and voltage stimulus signals may be performed at random.

The time interval between the succeeding alternating operations is preferably settable at random within a range from several seconds to several tens of seconds. In particular, the alternating time interval is preferably selected to be approximately 2 seconds to 1 minutes.

Furthermore, the frequency of the electrical stimulus signal is preferably selected to be a low frequency signal at a frequency between 0 and 60 Hz.

According to a seventh aspect of the present invention there is provided low frequency electrical stimulus signal generating apparatus comprising an input section for setting and adjusting conditions, and a stimulus signal generating section, said stimulus signal generating section including: a control section for previously sorting control information which is readily accessible; a current control section for generating a current stimulus signal controlled by said control information; a voltage control section for generating a voltage stimulus signal controlled by said control information; and a control system selecting section for alternately switching said current stimulus signal and said voltage stimulus signal based upon said control signal so as to output the switched signal as the electrical stimulus signal.

The control information of the current and electrical stimulus signals is preferably information which is selected from more than one sort of waveform, frequency and intensity, and the control information is selectable and variable based upon external input.

In a preferred embodiment, the alternating selection of the current and voltage stimulus signal is performed at random.

Furthermore, in a preferred embodiment, a time interval of the alternating selection of the current and voltage stimulus signals is set at random within several seconds to several tens of seconds, and the frequency of the electrical stimulus signal is selected to be a low frequency between 0 and 60 Hz.

The current or voltage control is based upon the waveforms of the sound information so as to modulate the electrical stimulus signal in an irregular manner. Accordingly, the frequency, waveform, and intensity of the sound information of favourable music are previously stored, so that a biological body can be provided with an electrical stimulus (percutaneous stimulus) in response to the tempo of this favourable music. As a result, the percutaneous stimulus can be applied to the biological body at predetermined timing at which the body can sense this stimulus in substantially real time, with the result that improved curing effects can be achieved compared to the previously-proposed musical curing methods.

In addition, according to the preferred embodiment, the current control system and the voltage control system are alternately switched to give the alternating stimulus to the biological body, with the result that it is possible to avoid the situation whereby the biological body can feel no stimulus upon receipt of the electrical stimulus; therefore, unpleasant feelings can be eliminated, the effects of pain can be reduced, and the curative effects can be improved.

The invention will now be described by way of example with reference to the accompanying drawings, throughout which like parts are referred to by like references, and in which: <ul id="ul0001" list-style="none"><li>Figure 1 is a block diagram illustrating a basic arrangement according to an embodiment of the present invention;</li><li>Figures 2A and 2B are block diagrams, each of which shows a portion of a detailed block diagram of a low frequency electrical stimulus signal generating apparatus according to an embodiment of the present invention;</li><li>Figures 3A to 3K are voltage waveform signal diagrams of signals appearing in the circuit of Figures 2A and 2B;</li><li>Figure 4 is a schematic diagram for explaining a table conversion.</li><li>Figure 5 is a functional block diagram of a CPU shown in Figure 2A;</li><li>Figures 6 to 14 are flowcharts of operations according to embodiments of the present invention.</li></ul>

Figure 1 is a block diagram illustrating a basic arrangement for explaining aspects of the present invention, while Figures 2A and 2B are block diagrams each of which illustrates a portion of a detailed block diagram of a low frequency electrical stimulus signal generating apparatus embodying the present invention. In Figures 2A and 2B, portions indicated by the same reference marks "a" to "j" should be connected to each other.

Referring now to Figure 1, there is shown a low frequency electrical stimulus signal generating apparatus including a stimulus signal generating section 10 for generating a low frequency electrical stimulus signal, a host section 12 for selectively supplying data required to drive the stimulus signal general generating section 10, an electrode section 14 for applying the generated electrical stimulus signal to a biological or living body and, if required, a sound source device 16.

In the preferred embodiment, the host section 12 includes an input section 20 for inputting various types of signal to the stimulus signal generating section 10. These signals are to set the initial or predetermined conditions, to adjust the required conditions, or to initialize the generation of the electrical stimulus signal. The above-described predetermined conditions include, for instance, the amplitudes (or intensity), the waveforms, the frequencies, the stimulus patterns, controlling systems for controlling current or voltage, and selection of electrodes. In addition, if required, the host section 12 may further include a sound source device for generating music or other sounds, an electric converting or transducer device, such as a speaker or earphone for reproducing the acoustic information originating from the sound source device, and/or a display section 21 for visually displaying the generated electrical stimulus signals. Alternatively, instead of provision of a sound source device in the host section 12, it may be connectred to the stimulus signal generating section 10 as an external sound source device 16.

In the present embodiment, the stimulus signal generating section 10 employs a current or voltage control system. According to this system, the volume of the sound level supplied from the sound source device 16 is detected, and the physical quantities of the current or voltage stimulus signals such as frequencies, amplitudes (intensity) and pulse rate or shape are controlled in response to the detected volume levels, while these electrical stimulus signals are continuously modulated; thus modulated electrical stimulus signals are output from the stimulus signal generating section 10. In this case, the electrical stimulus signals are preferably selected in such a manner that the frequency of the stimulus signals is a low frequency within the frequency range of approximately 0 to 50 Hz, at which biological bodies such as patients feel pleasant. To this end, the stimulus signal generating section 10 includes a control section 30 having a CPU (central processing unit) for converting the volume level for controlling the physical quantities into predetermined controlling quantities, and for effecting other desired controls; a current control section 40 for controlling the current in response to the above-defined controlling quantities; a voltage control section 50 for controlling the voltage in response to the above-defined controlling quantities; a controlling system selection section 60 for selecting either the voltage stimulus signal generated from the voltage control section 50, or the current stimulus signal produced from the current control section 40; and an output section 70.

Moreover, in the preferred embodiment, the stimulus signal generating section 10 includes a waveform control section 80 for performing rhythmic stimulus (also referred to as "rhythmic modulation") by controlling the rhythm of the electrical stimulus signal in such a manner that the waveforms of both the current and voltage are controlled by a sound waveform less than approximately 200 Hz during presence of the sound, and by a quasi-sound waveform produced during absence of the sound, independently of the volume level.

In addition, according to the preferred embodiment, the control section 30 includes means for generating various control signals for waveforms, pulse widths, frequencies, intensity (amplitudes) and changing over as parameters to stimulate biological bodies in order to alternately change, at random, the current control system or voltage control system, independently of the music or other acoustic information. As will be discussed later, the pattern of the current or voltage stimulus signal is preset by this control means to the stimulus pattern suitable for the respective biological body.

Referring to Figures 2A and 2B, a description will now be given of the arrangements and also the controlling system. It shoudl be noted that the same reference numerals will be employed to designate the same circuit arrangements as those shown in Figure 1.

In Figure 2A and 2B, the acoustic information from the sound source device 16, e.g. a radio, a television or other acoustic device, is transferred via an amplifier 90 to a sound volume-to-DC level converter 91. The resultant volume level signal is fed to an A/D (analogue-to-digital) converter 92.

The output of the amplifier 90 is also connected to an electric­acoustic converter or transducer 95, such as a speaker or an earphone, via an electronic volume control 93 which can be adjusted by an external switch SW, and an amplifier 94. This output is reproduced and provided to the biological body as a hearing or audible stimulus. It should be noted that the sound reproduction system is not necessarily employed in this electrical stimulus aparatus, but may be substituted by the reproduction system of the external sound source device 16.

The output of the amplifier 94 may be displayed by a light emitting display section 21 in such a manner that variations in the acoustic information are displayed. Int his case, the output is processed in a DC converter 22 of the display section 21 which also includes a light emitting diode (LED) 23. It should also be noted that the light emitting display section 21 may be provided within the host section 12.

In the preferred embodiment, the control section 30 includes a series interface 31 for receiving the signal sent from the input section 20 of the host section 12 by way of a wireless or wire system, a central processing unit (CPU) 32 for performing various processes in response to the signal from the interface 31, a random access memory (RAM) 33 for reading and writing data required for performing the various processes in the CPU 32, a read only memory (ROM) 34 for reading out the necessary data which have previously been stored therefrom for processing in the CPU 32, a programmable time unit (PTM) 35 for automatically outputting arbitrary frequencies as an internal clock with respect to the data set by the CPU 32, an output port 36 for outputting the outputs containing various control signals fromt he control section 30 to other circuit arrangements, and an input port 37 for receiving an input to the control section 30, such as a signal to detect the end of one cycle of the frequency from the PTM 35.

A portion of the output derived from the output port 36 is supplied as a control signal to a pulse number generator 96, and a changing switch 97 for changing the signals from the PTM 35 and the pulse number generator 96.

In the preferred embodiment, both the current control section 40 and the voltage control section 50 commonly employ a waveform generating section 41 and a waveform selecting section 42 comprising, for instance, an electronic switch for selectively deriving the generated voltage waveform. A frequency or pulse number control signal is transferred to a frequency clock section 43 of this waveform generating section 41 via the changing switch 97, and the frequency control signal from the output port 36 is also supplied thereto. Moreover, data for changing the pulse width of the oltage waveform to be generated is transferred to a pulse width data son of the waveform generating section 41.

In the waveform generating section 41, there is provided a waveform generating circuit 45. This waveform generating circuit 45 employs plenty of circuits from which various types of voltage waveform signals can be output, as illustrated in Figures 3A to 3K. The frequency of the voltage waveform signal can be controlled by a signal from the frequency clock section 43, and furthermore, the width of the signals can be varied by the data from the pulse width data section 44. It should be noted that such waveform generating circuit 45, frequency clock section 43 and pulse width data section 44 can be easily fabricated by utilizing conventional electronic circuit techniques, and therefore need employ no specific electronic circuit. At least one or more than two of the waveform generating circuits 45 are operated to select one, or more than two sets of the voltage waveform patterns in response to the control signal derived from the output port 36 as a waveform select signal. Also, the waveform generating section 41 is so designed that one or more than two sets of the voltage waveform patterns output from the waveform generation section 41 can be derived based upon a waveform select signal from the output port 36. The circuit arrangement of the waveform selecting section 42 may also be manufactured by employing conventional circuit techniques, and requires no specific circuit arrangement.

One of the voltage waveform signals selected by this waveform selecting section 42 is supplied to a current stimulus generating circuit 47 via an intensity (amplitude) setting circuit 46 of the current control section 40. The other of the voltage waveform signals is supplied to a voltage stimulus generating circuit 51 of the voltage control section 50.

In the current control section 40, the voltage waveform signal input into the intensity setting circuit 46 is set to a voltage waveform signal having a suitable amplitude in response to the control signal from the output port 36, whereas in the current stimulus generating circuit 47, its input voltage waveform pattern is converted into a current waveform type electrical stimulus signal having the same pattern as the voltage waveform pattern.

In, on the other hand, the voltage control section 50, the voltage waveform signal input into a supply voltage stimulus generating circuit 51 via the waveform selecting section 42, is converted into a voltage waveform type electrical stimulus signal having a particular intensity and frequency in response to an intensity (amplitude) and frequency control signal from the output port 36.

In addition, in the preferred embodiment, there is a controlling system selecting section 60 for selecting the electrical stimulus signal produced in accordance with either the current control system, or the voltage control system, and for supplying the selected electrical stimulus signal to a biological body as skin stimulus. This selecting operation can be performed in response to a selecting system control signal derived from the output port 36, whereby either the current control system, or the voltage control system is selected; otherwise, both control systems are alterately selected.

The electrical stimulus signal obtained via this controlling system selecting section 60 is transferred to an output section of the low frequency electrical stimulus signal generating apparatus. To this output section 70, electrodes for applying skin stimulus to more than one portion of the biological body are connected. A selection of the electrodes is under the control of an electrode selection controlling signal derived from the output port 36.

In the preferred embodiment, the waveform control section 80 includes: means for detecting acoustic information from the amplifier 90, for instance, a comparator 81; a low-pass filter 82 for passing therethrough acoustic information having a frequency lower than approximately 200 Hz; a rhythm generator 83 for generating a quasi-acoustic waveform during a rest or mute period of the acoustic information; and a selection switch 84 for selecting the acoustic information having a frequency lower than approximately 200 Hz supplied from the low-pass filter 82 when the acoustic or sound information is detected by the comparator 81, and for transferring the quasi-acoustic information as a rhythm-modulated (stimulus) waveform to the waveform selecting section 42 when the comparator 81 detects no acoustic information. The above-described acoustic information is also transferred via an A/D converter 92 to the control section, and is dispalyed as a rhythmic illustration at the display section 21 under the control of the control signal from the output port.

In the present embodiment, the frequency of the electrical stimulus signal for providing the skin stimulation is selected to be a low frequency. In the preferred embodiment, a frequency range is determined to be approximately 0 to 60 Hz, at which a biological body receives a pleasant sensation. By controlling either the current controlling or the voltage controlling in accordance with the sound volume level of the sound source, the electrical stimulus signal is modulated.

In the case of this current controlling system, cells of a biological body feel electric charges as energy, whereas in the case of the voltage controlling system, a small current is sufficient if the body is to feel the same pleasant sensation as that in the current controlling system, because the voltage is fluctuated. It is known in the art that, according to both controlling systems, a biological body can feel a pleasant sensation.

In the preferred embodimetn, the following three modulations are performed. <ul id="ul0002" list-style="none"><li>(1) The electrical stimulus signal is modulated by controlling the frequencies of the current and voltage, amplitude and pulse number, in relation to the sound level.</li><li>(2) The electrical stimulus signal is rhythm-modulated by controlling the current and voltage while using proper sound waveforms and quasi-sound waveforms having frequencies lower than about 200 Hz, without utilizing the sound level.</li><li>(3) The electrical stimulus signal is stimulus pattern-modulated by controlling the current and voltage patterns based upon a combination of various types of control information (waveforms, frequencies and amplitudes) which is previously set in the control section, without using the sound information.</li></ul>

Referring now to Figures 4 to 16, a detailed description will be given. Figure 4 is a schematic diagram for explaining a table conversion. Figure 5 is a functional block diagram of the CPU 32. Figures 6 to 14 are flowcharts of the operations according to the preferred embodiment, where the respective processing steps are indicated by "S".

Sound level frequency modulation will now be described.

First, a power switch is turned on to energize the music source device 16. Thus, acoustic information such as music is produced, thereby giving hearing stimulation to a biological body such as a patient.

The acoustic or sound information originating from the music sound device 16 is converted into a sound level composed of data of suitable bit numbers such as, for example, 8-bit data or 256-bit data, as illustrated in the upper column of Figure 4, by utilizing a sound volume-to-DC level converter 91 and an A/D converter 92 in real time processing.

Predetermined initial information containing the modulation, waveform, frequency, electrode selection, controlling system and so on is input by the input section 20 (e.g. an input key) of the host section 12 to the control section 30 of the stimulus signal generating section 10. Based upon this initial information, the processing is performed by the setting means of the CPU 32 (S1), and corresponding control information is read out from the ROM 34, or converted into predetermined control information. Thereafter, the above-described control information is supplied to the respective circuit arrangement components of the output port 36 to set the initial conditions (S2).

For instance, a waveform select signal is transferred to a waveform generating section 41 to actuate the waveform generating circuit 45, while this control signal is sent to the pulse width data section 44 so as to initial-­set the proper pulse width.

When the initial frequency information is sent to the frequency clock section 43, the frequency of the voltage waveform signal from the waveform generating circuit 45 is initial-set in such a manner that a biological body feels the maximum stimulation, for instance, at 30 Hz, when the waveform of the electrical stimulus signal is the same. This initial setting of the frequency is set independently of presence of the sound information supplied from the music sound device 16.

Simultaneously, the control signal is supplied to the voltage controlling and current controlling system selecting section 60 in order to select either controlling system, thereby determining the corresponding electrical stimulus signal.

The intensity of these electrical stimulus signals is set every time the control signal read out from the ROM 34 is transferred to an intensity setting circuit 46 and a voltage stimulus generating circuit 51 in accordance with the selection by the input section 20. This intensity of the electrical stimulus signal can be adjusted until a user feels a pleasant sensation while receiving this electrical stimulus signal.

When this stimulus intensity reaches a desired level, the start input is transported to the control section 30 by turning on the start key of the input section 20 in the host section 12, the medical treatment commencement data is sent to the stimulus signal generating section 10 (S3) while processing in the CPU 32, and then, the control section 30 starts to receive the volume level from the A/D converter 92 (S4). This signal reception is carried out by the sampling operation of the CPU 32. The respective volume levels are once written into the RAM 33, which have been acquired every sampling operation (S5), and are sequentially read out from the RAM 32, if required (S6). The volume level of data of suitable bit numbers such as, for example, 8-bit data or 256-bit data is converted in the CPU 32 into 16-stepped level data (S7).

In this level conversion, not only a zero volume, but also a lower volume is recognized as the electrical stimulus signal having the zero level intensity, which forcibly corresponds to the zero step. The 16-step volume levels are converted into the corresponding frequencies for the lower frequency region (step 8). According to this level conversion, the conversion frequencies corresponding to the respective volume levels are previously stored in the ROM 34 in table form, and thus, the corresponding frequency is read out by comparing it with the frequency conversion table every volume level (S8). This frequency information is sent via the ouput port 36 to the corresponding circuit arrangement (S9). In this case, the period of sampling is preferably selected to be in a range from approximately 0.01 to 0.5 seconds, for example, at which a biological body senses or feels practically in real time. Also, as the frequency table, the stimulus frequencies from 0 to 60 Hz are allocated to the 16-step volume levels, as illustrated in Figure 4, at which a biological body feels comfortable or pleasant. The frequencies of the stimulus signal are preferably selected to be in a range from 0 to 30 Hz. As is easily understood from Figure 4, the volume level "0" is set to 1.5 Hz, the level "1" is set to 2 Hz, the level "5" corresponds to 5 Hz, the level "10" is equal to 10 Hz, the level "11" is selected to be 15 Hz, ---, the level "15" is selected to be 30 Hz. To carry out such frequency converting, the CPU 32 includes conversion means 102 for performing the frequency conversion by the sampling operation (See Figure 5).

When the volume level is frequency-converted and output from the output port 36 every sampling period, this frequency is supplied to the frequency clock section 43 of the waveform generating section 41 and the voltage stimulus generating circuit 51, whereby the frequencies which have been initially set are sequentially updated by the frequencies newly converted by the received volume level. Under this condition, the current or voltage frequency converting operation is effected, so that the frequency modulation of the electrical stimulus signal can be automatically achieved.

As previously described, music and other sounds are utilized as a hearing stimulus, the sound volume level supplied from the sound source device 16 is sampled in substantially real time in synchronism with the hearing stimulus, and the frequency of the electrical stimulus signal is modulated to the frequency corresponding to the sound volume level at the same time as the sampling time, whereby this electrical stimulus signal is applied to a biological body as a skin or percutaneous stimulus.

The most important aspect of such a frequency modulation is to substantially perform the real-time sampling, and also to set the electrical stimulus (corresponding to the percutaneous stimulus) in response to this sampling oepration. In the preferred embodiment, when the sound volume (sound pressure) level is equal to zero, or a very low level (e.g. less than one sixteenth (1/16) of the maximum level), the frequency is set, for instance, to be less than 1.5 Hz. Under such circumstances, the waiting time period for the succeeding stimulus is preset as follows. For instance, for the 1 Hz frequency, the waiting time period is 1 second; for the 0.5 Hz frequency, the waiting time period is 2 seconds; for the 0.25 Hz frequency, the waiting time period is set to 4 seconds. As a result, when using actual music, no percutaneous stimulus is performed during the rest time and lower sound volume conditions. Since no stimulus time of this percutaneous stimulus will in practice be synchronized with no stimulus time period of the hearing stimulus, the cerebrum cortex feels no or reduced pain because the nerve supervision may occur by the experimental concept in the music field, which improves the effects of the cure.

When the waiting time period for the subsequent percutaneous stimulus becomes long, the case may arise where in fact generation of the electrical stimulus signal does not reflect the hearing stimulus. To avoid such a problem, in the preferred embodiment, the control section 30 of the stimulus signal generating section 10 includes frequency forcibly converting means 103 for forcibly converting the input signal to a new frequency corresponding to the newly sampled volume level, when the waiting time period becomes longer than a predetermined level, while continuously monitoring the converting frequency and the sound volume level.

Operation flows of the frequency forcibly converting means 103 will now be described with reference to Figure 8.

At first, a judgement is carried out whether or not the sampled volume level is lower than one sixteenth of the maximum level (S10). If the answer is NO, another judgement is performed whether or not the present frequency is lower than, for instance, 5 Hz (S12). If the answer is YES, that is, if the sound volume level is lower than one sixteenth of the maximum level, the cure intensity is set to the zero step (S11). Then, if the frequency is higher than 5 Hz, a judgement is made whether or not one cycle of this frequency is completed (S13). If one cycle of the frequency is not yet completed, the cure intensity is set to the setting intensity (i.e., the initial setting intensity) (S16). When one cycle of this frequency is accomplished, the volume level is converted into the frequency corresponding to the volume level which has been acquired in the succeeding sampling operation (S15). The resultant signal is output via the step S16. When the present frequency is lower than 5 Hz which has been judged in the above step S13, it is compared with the secound volume level obtained at the previous sampling oepation occurring just before the present sampling operation (S14). If the present volume level is higher than the previous volume level, it is forcibly set to the frequency corresponding to the present volume level during the signal process in the step S15, and thereafter processed in the step S16 to output the resultant signal. On the contrary, if the present volume level is lower than the comparison level, the process of the step S16 is carried out. The above-described overall signal process is continuously performed during the operation of the electrical stimulus signal generating apparatus. It should be noted that although the converting means 102 and the frequency forcibly converting means 103 are separately employed in the preferred embodiment, the frequency forcibly converting means 103 may be included as part of the converting means 102. In addition, the operation flow is not limited to the above-described flow.

In order to effect amplitude modulation, at first, an initialization is performed in a simialr manner to that effected for frequency modulation (see Figures 5 and 6). In this embodiment, the initialized intensity corresponds to the maximum intensity by which a biological body feels maximum stimulus. This initialized intensity is equal to a set intensity which is written in the RAM 33 and read therefrom, if required.

When, for example, an 8-bit data sound volume level is sequentially taken in by the sampling operation, the set intensity is sequentially updated in real time by another intensity (amplitude) corresponding to the above sound level in a range from 0 to 100 percent (0 - 100%). As a result, amplitude modulation for the electrical stimulus signal can be achieved, whereby the intensity modulation for the percutaneous stimulus can also be achieved. This amplitude (intensity) conversion is performed continuously.

This amplitude modulation is mainly performed by employing the cure intensity setting means 104.

Referring now to Figure 9, the amplitude modulation process will be described. First, the set intensity is read out from the RAM 33 (S20), and secondly, the 8-bit volume level is read out from the RAM 33 (S21). Subsequently, to execute the following equation (I), the 8-bit data of this volume level is divided by 256, and the resultant quotient is multiplied by the set intensity to obtain the cure intensity, that is to say, an amplitude control value (S22). It should be noted that the calculation process is not limited to the above process. The cure intensity = (the set intensity) x {(the 8-bit data of the sound volume data)/256}      ...(I).

In this case, the 24-stepped electrical stimulus signal intensity is preferably obtained as the amplitude control value, which is set within a range from 0 to 100 percent. Also, when the music/sound volume level is equal to zero, or ver low, the electrical stimulus signal intensity is forcibly set to zero. However, the intensity becomes low when the sound volume level is low, even if this intensity is not set to zero. As a result, a biological body feels no stimulus so that the body sensation is related to the music/sound.

In the preferred embodiment, the calculation process is accomplished int he functional block of the cure intensity setting means 104. It is also possible that the cure intensity (or amplitude control value) is stored as the conversion table in the ROM 34, and this conversion table is read to convert the data into the cure intensity.

The resultant amplitude control value is output from the ouput port 36, and then transferred to the intensity setting circuit 46 and the voltage stimulus generating circuit 51, where the amplitudes of the current and voltage stimulus signals are modulated. In this case, either the current control system, or the voltage control system is selected by the control system selecting section 60 in the same manner as in the frequency modulation system.

In accordance with this amplitude modulation, the sound volume level supplied from the sound source device is sampled in substantially real time as the hearing stimulus, and amplitude-converted at the same time as the sampling time, so that the amplitude of the electrical stimulus signal is set within a range from 0 to 100 percent of the set intensity in real time.

The main feature of the present amplitude modulation is to supply no electrical stimulus when the music or other sound is in a rest condition and the sound volume is low. That is to say, no stimulus signal of the percutaneous stimulus can be produced in accordance with the music, which causes a significant curing effect in the music curing method.

In order to effect pulse number modulation, similar initialization as for frequency modulation is carried out. Instead of the frequency, a pulse having a pulse rate of, for instance, 16 pulses/second (corresponding to 30 Hz) is produced from the pulse number generator 96 (Figures 5 and 6).

Then, when the 8-bit data of the volume level is sequentially read out, it is sequentially updated in real time by the pulse numbers corresponding to the read volume level within a range of the initialized set pulse number as a maximum pulse number, so that control of the electrical stimulus signal can be achieved, and thus the pulse number control of the percutaneous stimulus can be achieved. This pulse number modulation is continuously performed in the preferred embodiment.

This pulse number modulation is mainly performed by employing the pulse number setting means 105 of the CPU 32.

In accordance with the pulse number modulation process (see Figure 10), the sound volume level subdivided into 16-stepped levels is read out from the RAM 33 (S23), and then the corresponding pulse-number-converted value is obtained from the ROM 34 by the table conversion (S24). Subsequently, the following equation (II) is calculated (S25). Pulse number control value = (16-stepped converted values)-1      ...(II)

In the preferred embodiment, the pulse number control value calculation is based upon the equation (II), and thereafter sent via the ouput port 36 to the pulse number generator 96. Accordingly, the pulse is generated at the pulse rate corresponding to the sound volume level which has been sampled, and transferred via a changing switch 97 to the frequency clock section 43 in the waveform generating section 41. As a result, the current and voltage stimulus signals can be produced as the pulse signal, the pulse rate of which is controlled. The pulse numbers employed in the preferred embodiment are preferably set in the range from 0 to 30 pulses/second at which a biological body feels a pleasant sensation.

According to the above equation (II), the pulse number becomes zero when music is in the rest condition and the sound volume is low.

It should be noted that the calculation of the pulse number control value is not limited to the above-defined equation (II), but may be realized by different calculation methods. Instead of the equation calculation, the pulse number control value corresponding to the sound volume level is previously stored in the ROM 34, and then, the necessary data may be obtained from the ROM 34 by way of the table conversion.

As has been described in the above preferred embodiment, the percutaneous stimulus can be applied to a biological body with the hearing stimulus in substantially real time by employing pulse number modulation, in similar manner to the frequency modulation.

Referring now to Figure 11, a rhythmic modulation process will be described, not using the sound volume level. The setting conditions such as the modulation system, waveform, stimulus pattern, control method, and electrode selection are input into the control section 30 from the input section 20 of the host section 12 as curing data. This processing will now be described. As in the above-described frequency modulation and other modulations, the initial data setting is performed based upon these setting conditions. To sufficiently feel the strong intensity, a waveform having a large wave crest is employed while the initial setting is effected. For example, when a biological body starts to feel, as optimum stimulus, the stimulus pattern, the medical treatment will be commenced. At first, the rhythmic modulation command information is sent from the output port to the waveform control section 80 by the modulation system setting means 106 of the CPU 32, so as to enable this waveform control section 80 (S30). A judgement is made whether or not the sound information supplied from the sound source device 16 is present or not (S31). When the output is present, it is compared by the comparator 81 with, for instance, a set level, and the changing switch 84 is changed over to the low pass filter 82 so as to send sound information of frequency lower than approximately 200 Hz to the waveform selecting section 42 as the rhythmic modulation waveform (S32). When, on the other hand, no sound information is present (S33), in response to the command sent from the modulation system setting means 106, the waveform selection 42 is changed to select only the rhythm-modulation waveform, which is sent to the succeeding stage (S34).

The rhythm-modulated waveform is sent from this waveform selecting section 42 to the voltage stimulus generating circuit 51, and also to the current stimulus generating circuit 47 via the inensity setting circuit 46 (S32). Based upon both the rhythm-modulated waveform, the rhythm and/or intensity of the current and voltage stimulus signal are controlled (S33), and are output as the electrical stimulus signal in accordance with either the current or voltage controlling system, as in the above-described other modulation systems. As a result, rhythmic and intensity stimulus can be applied to a biological body.

In the preferred embodiment, the reason why the low pass filter has a pass band lower than approximately 200 Hz, is that the stimulus which is achieved by the frequency pattern within this frequency range can be derived from the stimulus obtained by the bass and drum sounds in music.

By receiving such rhythmic stimulus, unpleasant sensations of the biological body can be relaxed, mitigated or cured.

In the preferred embodiment, the parameters for stimulus patterns selected by the control section 30 are automatically varied with no reaction to music. Thus stimulus pattern modulation can be achieved without employing a sound source device alternately changing the current or voltage control systems. These parameters typically contain waveforms, pulse widths, frequencies and intensities.

In the present embodiment, two examples wehre the frequencies and intensities are used as variable parameters, will now be described for the stimulus pattern modulation processing with reference to Figures 2, 5 and 12.

The initial setting values and also the variable parameters values for the frequencies and intensities have been previously stored in the ROM 34.

Firstly, the case will be described in which the frequency is variable in stimulus pattern modulation processing.

In response to commands sent from the input section 20, the stimulus parameter modulation is designated by a modulation system setting means 106, as in the previous modulation system (S40). Then, the initial setting for the waveform, pulse width and intensities are performed by the setting means 101 (S41). Thereafter, in response to this command, the stimulus parameter setting means 107 is actuated to read out the frequencies from the ROM 34. These frequencies are output via the ouput port 36 to the waveform generating section 41 and voltage stimulus generating circuit 51 (S42). These frequencies may be fixed values, or variable at random. Thereafter, the electrical stimulus signal is similarly controlled as in the previous frequency modulation (S43). Subsequently, based upon the modulation system selected by the above-described modulation system setting means 106, the command for alternately outputting the current and voltage stimulus signals at a constant rate, or random rate, is given to the control system selecting section 60 by this setting means 106. Accordingly, these stimulus signals are altnerately output (S44), which enables the voltage and current stimulus to be alternately applied to a biological body.

The above alternate selection can be performed by the command from the input section 20 and the stimulus signals are read out and output from the ROM 34. These processes can be performed by the setting means 101.

Secondly, the situation will be described in which the intensity is variable in stimulus pattern modulation processing. Since this intensity variable process is, in principle similar to the above-described frequency variable process, the frequency as illustrated in Figure 12 is merely substituted by the intensity (amplitude) for the intensity variable process. However, to initialize the frequency, a control signal is sent from the setting means 101 to the PTM 35 and thus, the frequency is automatically locked by this PTM 35. The stimulus pattern modulation is carried out by such an intensity variable system whereby the voltage and current stimulus signals can be alternately applied to the biological body.

In both types of the stimulus pattern modulation processes, the stimulus patterns are controlled by the program previously stored in the CPU 32.

As has been described, the current and voltage stimulus signals are alternately changed in this type of stimulus pattern modulation system. The time period required for this signal change is selected to be from several seconds to several minutes. It is however preferable to select approximately two seconds to one minute.

The reason why such alternation stimulus employing the voltage and current stimulus signals is applied to the biological body is as follows. When, for instance, the current control is performed as a sine wave and an expotential function waveform, and also the voltage control is performed as a rectangular wave and a spike or pin-shaped waveform,no stimulus is given to the biological body during the current control, even if the same current value as in the voltage control method is used. Although the biological body feels no stimulus, it receives electric changes in the current control method, so that this current stimulus method is effective for a biological body under anesthesia, children, or a person who does not like to receive the electrical stimulus signal. However, if only current stimulus causes no sensation or feel to a biological body, it may feel the proper stimulus by alternately changing the voltage and current stimulus

Figure 13 shows one example of a main control flow of apparatus embodying the present invention.

First, a check is made whether or not the signal sent from the input section 20 is received (S50). If the input signal is received, then the subsequent frequency processing operation is performed after the data used for the above judgement and also each of the data have been set. If such an input signal is not yet received, the subsequent frequency processing operation is similarly carried out.

Thereafter, a judgement is made whether or not the frequency modulation is performed (S52). If its command is made, then the control advances to the next processing step after the frequency modulation processing has been carried out (S53). If no command is made, the control directly advances to the succcceeding process.

Thereafter, a judgement is made whether or not amplitude modulation is to be performed (S54). If its command is made, the control advances to the succeeding step after the amplitude modulation processing as been accomplished (S55). If no command is made, the control directly advances to the subsequent step.

Subsequently, a judgement is made whether or not rhythmic modulation is to be done (S56). If the command is made, then the control advances to the next processing step after the rhythmic modulation has been executed (S57). If no, then the control advances directly to the subsequent processing step.

Next, a judgement is made whether or not pulse number modulation is to be done (S58). If the command is made, the control advances to the subsequent processing step after the frequency modulation process has been performed (S59). If there is no command, the control directly advances to the next processing step.

Then, a judgement is made whether any modulation processing is to be done (S60). If no modulation command is made, the control advances to the next processing step after no modulation processing has been performed (S61). Otherwise, the control advances directly to the succeeding process step.

Then, in addition, a predetermined process such as a stimulus pattern process is controlled (S62).

It should be noted that these signal processing are repeated during a series of operations of the low frequency stimulus signal generating apparatus. The judgement processings for judging the sorts of various modulations are performed in the modulation system setting means 106 in the CPU 32. The judgement results are sent to the the respective frequency forcibly converting means 103, cure intensity setting means 104, pulse number setting means 105, and stimulus parameter setting means 107. Then, the desired signal process is effected.

In Figure 5, the sound volume level data which has been input from the A/D converter 92 into the CPU 32, is converted into 8-bit data and set into the RAM 33 by means of the converting means 102 as illustrated in the flowchart of Figure 14 (S63). This data conversion is carried out in such a manner that the data value derived from the A/D converter 92 is converted into the 8-bit data having 256 steps. This set data is further converted into 16-stepped data and set into another field in the RAM 33 (S64).

A brief explanation will now be made of the current stimulus generating circuit 47 and the voltage stimulus generating circuit 51 (which have previously been described in outline as shown in Figure 2) with reference to Figures 15 and 16.

It should be noted that both generating circuits 47 and 51 can be assembled by employing conventional electronic circuit technology.

In Figure 15, there is shown a block diagram of one example of the current stimulus signal generating circuit. As previously described, this circuit is operable to output a current having the same waveform as that of the input voltage.

This generating circuit may comprise a first stage 110, a second stage 120 and a third stage 130, including, for instance, an operational amplifier 111, a photocoupler 112, 121 and a darlington circuit 132.

The first stage 110 includes the operational amplifier 111 and a light emitting diode 112 of the photocoupler to convert the voltage waveform into the current waveform at a constant voltage level, and to convert the input voltage into a photo-output.

The second stage 120 includes a light receiving element 121 of the photocoupler, a current-to-voltage converting circuit 122 for converting the current supplied from the light receiving element 121 into a voltage, and an operational amplifier 123 for amplifying the resultant voltage, so as to produce an amplified voltage.

The third stage 130 produces the output current by amplifying the voltage with an operational amplifier 131 and thereafter, by converting the amplified voltage into a current in the darlington circuit 132. In this case, the circuit arrangement is designed so that even if the impedance of the biological body to which this output current is provided is varied, a current having the same waveform as that of the voltage can be continuously output by feeding back the output of the darlington circuit 132 to the operational amplifier 131.

It should be noted that the circuit arrangement of the current stimulus signal generating circuit 46 is not limited to the above embodiment, but may be modified.

The voltage stimulus generating circuit is a circuit for simply amplifying the input voltage, a suitable circuit arrangement for which is shown in Figure 16. This voltage stimulus generating circuit 51 comprises an operational amplifier 141 and a push-pull amplifier 142 for amplifying the output from the operational amplifier, so as to output a voltage which is obtained by converting the amplitude and frequency of the input voltage into a predetermined voltage.

Similarly, the generating circuit 51 is not limited to the above-­described circuit arrangement, but may be modified.

The control method and/or apparatus are not restricted to the above-­described method and circuit arrangement, but may be modified, for example as follows.

For instance, the arrangement of the apparatus as illustrated in Figure 2 may be constructed by employing other circuit arrangements. Similarly, the operation method may be modified.

It is also possible to generate the electrical stimulus signal by combining more than two modulations selected from the above-described frequency modulation, amplitude modulation, pulse modulation, rhythmic modulation, and stimulus pattern modulation (alternate stimulus).

As has been described in detail, the low frequency electrical stimulus in accordance with the sound volume (sound pressure) levels of music or other sounds can be given to a biological body in substantially real time by alternately changing the current or voltage control system. As a result, improved curative effects as well as pain relaxation effects can be achieved, compared with the previously-proposed cure systems based on the l/f fluctuation theory.

Particularly in the case of rhythm modulation, the current or voltage stimulus signal is controlled based upon the sound waveforms when the sound information is input. When no sound information is present, these voltage and current stimulus signals are controlled based upon a quasi-sound waveform. Then, since one of these stimulus signals can be output as the electrical stimulus signal in real time, pain reduction and curing effects can be improved compared with the previously-proposed l/f fluctuation theory. In addition, since the present arrangement utilizes only sound information containing low frequencies, typically lower than approximately 200 Hz (such as bass and drums in music), unpleasant feelings can be effectively reduced or eliminated by producing a rhythmic feeling.

Furthermore, particularly in the case where the current stimulus signal and voltage stimulus signal are altenrately switched-over to output as the electrical stimulus signal, since a biological body can be electrically stimulated in real time in accordance with the tempo of the favourable music, enhanced curing effects and pain reduction can be realized in the field of the musical curing method, as compared with the previously-­proposed musical curing method employing l/f fluctuation theory. Furthermore, as the current and voltage control systems are alternately switched to give such alternating stimulus to the biological body, it is possible to avoid the absence of stimulus feeling for the biological body. Accordingly, lack of sensation or feeling can be eliminated, pain effects can be reduced and the curative effects can be improved. Moreover, since a low frequency electrical stimulus signal is employed, relaxation can be expected both physically and mentally.