Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
Abstract
A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 ug/cm2hr and preferably in the range of 50-150 ug/cm2hr. Ethanol delivered at a rate of from 250-500 ug/cm2hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.
Term
Term ended
Projected expiry passed 2 May 2006, 20.4 years ago.
- Priority
- Filed
- Published
- Projected expiry
- Today
Every citation, both ways
| Document | Relation | Office | Category | Cited during |
|---|---|---|---|---|
| GB2095108A | Cites | United Kingdom | A | Search report |
| DD217989A1 | Cites | German Democratic Republic (until 1990) | A | Search report |
| US4573996A | Cites | United States of America | XP | Search report |
11 members in 7 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 730714 | United States of America | – | |
| 73071485 | United States of America | A | |
| 730714 | – | – | – |
| US19850730714 | – | – | – |
Members11
| Document | Office | Kind | |
|---|---|---|---|
| US4615699A | United States of America | A | |
| EP0200562A2 | European Patent Office (EPO) | A2 | |
| AU5703386A | Australia | A | |
| JPS61280427A | Japan | A | |
| US4681584A | United States of America | A | |
| EP0200562A3This record | European Patent Office (EPO) | A3 | |
| AU576724B2 | Australia | B2 | |
| ES554626A0 | Spain | A0 | |
| ES8900038A1 | Spain | A1 | |
| NZ216029A | New Zealand | A | |
| CA1262098A | Canada | A |
11 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | |
| Application deemed to be withdrawnWithdrawn18D | 18D | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWNSTAA | STAA | |
| Party data changed (applicant data changed or rights of an application transferred)RAP3 | RAP3 | |
| First examination report despatched17Q | 17Q | |
| Request for examination filed17P | 17P | |
| Designated contracting statesAK | AK | |
| Search report despatchedORIGINAL CODE: 0009013PUAL | PUAL | |
| Designated contracting statesAK | AK | |
| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI |
Numbers
- Publication
- 0200562
- Publication, DOCDB
- 0200562
- Publication, EPODOC
- EP0200562
- Application
- 86303367
- Application, DOCDB
- 86303367
- Application, EPODOC
- EP19860303367
Titles3
- English
- TRANSDERMAL DELIVERY SYSTEM FOR DELIVERING NITROGLYCERIN AT HIGH TRANSDERMAL FLUXES
- French
- Dispositif pour administrer de la nitroglycérine par voie transdermique à de hauts débits
- German
- System zur transdermalen Verabreichung von Nitroglycerin mit hoher Durchtrittsrate durch die Haut
Classification
- CPC, 4
- A61K9/7084
- A61K31/21
- Y10S514/964
- A61P9/00
- IPC, 4
- A61K31 045
- A61K9 70
- A61K31 21
- A61P9 00
Designated states11
- Contracting states, 11
- Austria
- Belgium
- Switzerland
- Germany
- France
- United Kingdom
- Italy
- Liechtenstein
- Luxembourg
- Netherlands (Kingdom of the)
- Sweden