Nova Patents
EP0199480A3

Hepatitis a virus vaccines

Abstract

The complete genome of the hepatitis A virus - (HAV) is disclosed. With the entire genomic sequence available, epitopes are identified by analogy to known picornaviruses such as polio virus, synthesized chemically, and conjugated to carrier proteins to provide protective vaccines against HAV. Alternate methods of preparing vaccines include preparation of specified peptide sequences using recombinant techniques, preparation of deleted virions by modifying the genome to destroy the replicase and LTR regions, and preparation of particulate immunogenic materials containing an epitope from HAV. The foregoing alternatives for vaccine preparation are described, and proteins thus prepared used to raise antibodies against HAV.

Term

Term ended

Projected expiry passed 3 April 2006, 20.5 years ago.

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Every citation, both waysCites: the store holds 6 of 7

Citations
DocumentRelationOfficeCategoryCited during
EP0061740A2CitesEuropean Patent Office (EPO)ASearch report
EP0154587A2CitesEuropean Patent Office (EPO)ESearch report
EP0175613A2CitesEuropean Patent Office (EPO)ESearch report
US4031203ACitesUnited States of AmericaXSearch report
US4164566ACitesUnited States of AmericaXSearch report
WO8501517A1CitesWorld Intellectual Property Organization (WIPO)XPSearch report
PROC. NATL. ACAD. SCI. USA, vol. 80, October 1983, pages 5885-5889, Baltimore, US; J.R. TICEHURST et al.: "Molecular cloning and characterization of hepatitis A virus cDNA"Non-patent––Search report
PROC. NATL. ACAD. SCI. USA, vol. 82, May 1985, pages 2627-2631, Baltimore, US; R. NAJARIAN et al.: "Primary structure and gene organization of human hepatitis A virus"Non-patent––Search report