EP0198352A3
Method for preparing (+)r-2-methyl-hexane-1,2-diol
Abstract
A method for preparing important stereospecific intermediates in the synthesis of prostaglandin analogs is disclosed. Said intermediates are (+)R-2-methyl-hexane-1,2-diol and (-)S-2-methyl-hexane-1,2-diol and are prepared via an asymmetric halolactonization reaction utilizing L-proline and D-proline, respectively as the chiral agent.
Term
Term ended
Projected expiry passed 4 April 2006, 20.5 years ago.
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Every citation, both waysCites: the store holds 1 of 2
| Document | Relation | Office | Category | Cited during |
|---|---|---|---|---|
| EP0034567A2 | Cites | European Patent Office (EPO) | A | Search report |
| TETRAHEDRON, vol. 35, 1979, pages 2337-2343, Pergamon Press Ltd; S.-S.JEW et al.: "Asymmetric halolactonisation reaction-1 - Asymmetric synthesis of optically active alpha,alpha-disubstituted-alpha-hydroxy acids from alpha,beta-unsaturated acids by the novel use of halolactonisation reaction" | Non-patent | – | – | Search report |
| TETRAHEDRON LETTERS, vol. 21, 1980, pages 2481-2482, Pergamon Press Ltd; Y.FUJIMOTO et al.: "(S)-citramalic acid, a useful chiral synthon for the synthesis of 15-deoxy-16(S)-hydroxy-16-methylprostaglandins" | Non-patent | – | – | Search report |
| CHEMICAL ABSTRACTS, vol. 98, 1983, page 730, no. 54485d, Columbus, Ohio, US; & ES-A-504 293 (REVILLA TORRES, JUAN) 01-06-1982 | Non-patent | – | – | Search report |
| CHEMICAL ABSTRACTS, vol. 98, no. 15, April 1983, page 579, no. 125404q, Columbus, Ohio, US; & JP-A-57 158 733 (SUNTORY, LTD) 30-09-1982 | Non-patent | – | – | Search report |
| TETRAHEDRON, vol. 40, no. 8, 1984, pages 1313-1324, Pergamon Press Ltd; D.SEEBACH et al.: "Alpha-alkylation of alpha-heterosubstituted carboxylic acids without racemization" | Non-patent | – | – | Search report |
7 members in 4 offices
Priority claims10
| Document | Office | Kind | Date |
|---|---|---|---|
| 723576 | United States of America | – | |
| 72357685 | United States of America | A | |
| 72357685 | United States of America | A | |
| 817068 | United States of America | – | |
| 81706886 | United States of America | A | |
| 81706886 | United States of America | A | |
| 723576 | – | – | – |
| 817068 | – | – | – |
| US19850723576 | – | – | – |
| US19860817068 | – | – | – |
Members7
| Document | Office | Kind | |
|---|---|---|---|
| EP0198352A2 | European Patent Office (EPO) | A2 | |
| JPS61238744A | Japan | A | |
| US4633025A | United States of America | A | |
| JPS638091B2 | Japan | B2 | |
| EP0198352A3This record | European Patent Office (EPO) | A3 | |
| CA1265819A | Canada | A | |
| CA1265819C | Canada | C |
12 legal events, as the office reported them to INPADOC
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| Event | Code | |
|---|---|---|
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | |
| Application withdrawn (corrected)WithdrawnR18W | R18W | |
| Application withdrawnWithdrawn18W | 18W | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: THE APPLICATION HAS BEEN WITHDRAWNSTAA | STAA | |
| First examination report despatched17Q | 17Q | |
| Designated contracting statesAK | AK | |
| Search report despatchedORIGINAL CODE: 0009013PUAL | PUAL | |
| Party data changed (applicant data changed or rights of an application transferred)RAP1 | RAP1 | |
| Party data changed (applicant data changed or rights of an application transferred)RAP1 | RAP1 | |
| Request for examination filed17P | 17P | |
| Designated contracting statesAK | AK | |
| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI |
Numbers
- Publication
- 0198352
- Publication, DOCDB
- 0198352
- Publication, EPODOC
- EP0198352
- Application
- 86104593
- Application, DOCDB
- 86104593
- Application, EPODOC
- EP19860104593
Titles3
- German
- Herstellungsverfahren von (+)R-2-Methyl-hexan-1,2-diol
- English
- Method for preparing (+)R-2-methyl-hexane-1,2-diol
- French
- Méthode de préparation du (+)R-2-méthyl-hexane-1,2-diol
Classification
- CPC, 2
- C07C59/115
- C07C31/20
- IPC, 2
- C07C31 20
- C07C59 115
Designated states1
- Contracting states, 1
- Sweden