CU20160120A7
Benzimidazol-2-amines as midh1 inhibitors
Abstract
The present invention relates to benzimidazole-2-amines with the general formula (I): FORMULA SPACE which inhibits the mutated isocitrate dehydrogenase 1 (mIDH1 R123H), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, methods for making them and intermediates useful for their preparation. The compounds of formula I are useful in the prophylaxis or treatment of various diseases, particularly in neoplasms.
Term
No projected expiry on record.
- Priority
- Filed
- Published
- Today
1 sheet
Sheet 1
49 members in 27 offices
Priority claims14
| Document | Office | Kind | Date |
|---|---|---|---|
| 14154680 | European Patent Office (EPO) | A | |
| 14154680 | European Patent Office (EPO) | A | |
| 141546804 | European Patent Office (EPO) | – | |
| 14182002 | European Patent Office (EPO) | A | |
| 14182002 | European Patent Office (EPO) | A | |
| 141820027 | European Patent Office (EPO) | – | |
| 2015052676 | European Patent Office (EPO) | W | |
| 2015052676 | European Patent Office (EPO) | W | |
| 141546804 | – | – | – |
| 141820027 | – | – | – |
| EP20140154680 | – | – | – |
| EP20140182002 | – | – | – |
| PCTEP2015052676 | – | – | – |
| WO2015EP52676 | – | – | – |
Members49
| Document | Office | Kind | |
|---|---|---|---|
| CA2939021A1 | Canada | A1 | |
| CA2939026A1 | Canada | A1 | |
| WO2015121209A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO2015121210A1 | World Intellectual Property Organization (WIPO) | A1 | |
| UY35991A | Uruguay | A | |
| TW201613874A | Taiwan Province of China | A | |
| AR099464A1 | Argentina | A1 | |
| AU2015217788A1 | Australia | A1 | |
| SG11201605810WA | Singapore | A | |
| AP2016009371A0 | African Regional Intellectual Property Organization (ARIPO) | A0 | |
| IL246785A0 | Israel | A0 | |
| DOP2016000208A | Dominican Republic | A | |
| CN105980365A | China | A | |
| CR20160361A | Costa Rica | A | |
| KR20160115991A | Republic of Korea | A | |
| MX2016010474A | Mexico | A | |
| EP3105209A1 | European Patent Office (EPO) | A1 | |
| EP3105210A1 | European Patent Office (EPO) | A1 | |
| CU20160120A7This record | Cuba | A7 | |
| PH12016501581A1 | Philippines | A1 | |
| JP2017505790A | Japan | A | |
| JP2017505793A | Japan | A | |
| EA201691590A1 | Eurasian Patent Organization (EAPO) | A1 | |
| PE20170143A1 | Peru | A1 | |
| CL2016002033A1 | Chile | A1 | |
| CN106573897A | China | A | |
| US2017197921A1 | United States of America | A1 | |
| US2017197922A1 | United States of America | A1 | |
| BR112016018604A2 | Brazil | A2 | |
| HK1226398A | Hong Kong, China | A | |
| HK1226398A1 | Hong Kong, China | A1 | |
| MA39256A1 | Morocco | A1 | |
| US9951027B2 | United States of America | B2 | |
| US9957235B2 | United States of America | B2 | |
| SV2016005257A | El Salvador | A | |
| EP3105210B1 | European Patent Office (EPO) | B1 | |
| EA031655B1 | Eurasian Patent Organization (EAPO) | B1 | |
| US2019062285A1 | United States of America | A1 | |
| CU24410B1 | Cuba | B1 | |
| CN105980365B | China | B | |
| JP6534675B2 | Japan | B2 | |
| AU2015217788B2 | Australia | B2 | |
| TWI666202B | Taiwan Province of China | B | |
| EP3105209B1 | European Patent Office (EPO) | B1 | |
| CN106573897B | China | B | |
| US10442772B2 | United States of America | B2 | |
| ES2732902T3 | Spain | T3 | |
| JP6688735B2 | Japan | B2 | |
| CA2939021C | Canada | C |
Numbers
- Publication
- 2016000120
- Publication, DOCDB
- 20160120
- Publication, EPODOC
- CU20160120
- Application
- 20160000120
- Application, DOCDB
- 20160120
- Application, EPODOC
- CU20160000120
Titles2
- Spanish
- BENZIMIDAZOL-2-AMINAS COMO INHIBIDORES DE MIDH1
- English
- BENZIMIDAZOL-2-AMINES AS INHIBITORS OF MIDH1
Classification
- CPC, 9
- C07D235/30
- A61K31/4184
- A61K31/4439
- C07D401/12
- A61P35/00
- A61P35/02
- A61P35/04
- A61K45/06
- A61K2300/00
- IPC, 3
- A61K31 4184
- A61P35 00
- C07D235 30