Preparation of n-2-diethylamino-ethyl-2 1 methoxy -4-amino- 5-chlorobenzamide

1328580 Anisamide derivative FRATMANN AG 6 Dec 1971 [4 Aug 1971] 56496/71 Heading C2C 4 - Amino - 5 - chloro - N - [2 - (diethylamino)- ethyl] - o - anisamide is prepared by hydrolysing 5 - chloro - N - [2 - (diethylamino)ethyl] - 4- (p - toluenesulphonamido)- o - anisamide, obtained by reacting 2-(diethylamino)ethylamine with methyl 5 - chloro - 4 - (p - toluenesulphonamido) - o - anisate, resulting from the chlorination of methyl 4-(p-toluensulphonamido)- o-anisate, which is made by reacting p-toluenesulphonyl chloride with methyl 4-amino-oanisate obtained by treating p-aminosalicylic acid with dimethyl sulphate. Reference has been directed by the Comptroller to Specification 994,023.