Postopek za pripravo 1-hidroksi-2-piridinov

1,238,106. Pyridone derivatives. FARBWERKE HOECHST A.G. 27 Aug., 1969 [31 Aug., 1968], No. 42726/69. Heading C2C. Novel compounds I in which R 1 is 1-17C alkyl, 5-8C cycloalkyl, cyclohexylalkyl or phenalkyl with 1-3C alkylene chain, or α-furyl, which groups may be substituted by halogen atoms; and R 2 -R 4 are H or 1-4C alkyl, or an adjacent pair may together form a tri- or tetra-methylene chain and in which there are at least 2C in R 1 -R 4 taken together; are prepared by reaction of hydroxylamine or a salt or functional derivative thereof with an ester or or mixtures thereof followed by cyclization (R 5 = 1-6C alkyl). Intermediates isolated are the starting esters which may be prepared by reaction of R 1 COCl with and the oximes and Pharmaceutical compositions for topical application as antimycotics in treating dermatomycoses comprise a compound I together with a suitable carrier.