Container for nasal administration

Nasal cavity drug delivery container technical field

[0001] The present invention relates to a nasal cavity administration container for supplying medicinal liquid to the nasal cavity.

Background technique

[0002] As disclosed in Japanese Patent Application Laid-Open No. 2001-137344 (Patent Document 1), a nasal cavity administration container is used to supply liquid medicine to the left and right nasal cavities. When using the nasal cavity administration container, first, in a state where the nasal cavity administration container is inserted into one nasal cavity, a predetermined amount of medicinal solution is supplied to the one nasal cavity. Then, with the nasal cavity administration container inserted into the other nasal cavity, the remaining amount of the medicinal solution is supplied to the other nasal cavity.

[0003] As a nasal cavity administration container, it is generally desirable to simply and appropriately supply a predetermined amount (eg, half the amount) of the medicinal solution to each nasal cavity when the medicinal solution is supplied to the left and right nasal cavities.

[0004] Prior Art Literature

[0005] Patent Literature

[0006] Patent Document 1: Japanese Patent Laid-Open No. 2001-137344 Summary of the Invention

[0007] The technical problem to be solved by the invention

[0008] An object of the present invention is to provide a nasal cavity administration container that can more simply and appropriately supply the medicinal solution when the medicinal solution is supplied to the left and right nasal cavities.

[0009] Technical solutions adopted to solve technical problems

[0010] The nasal cavity administration container according to the present invention is provided with a main body and a plunger movement amount restricting member, wherein the main body includes a medicinal solution storage section with a spray nozzle on one end side and an opening on the other end side, and A plunger inserted into the medicinal solution reservoir from one end side through the opening, and provided with a pressing part on the other end; the plunger movement restriction member is included between the pressing part and the opening The stop part is arranged to be engaged with the main body part, and the engagement state with the main body part is released only when the pressing part is in contact with the stop part. In addition, the column The plug is pushed into the liquid storage portion to advance until the pressing portion comes into contact with the stopper, and the plunger is removed from the main body by the plunger movement restriction member. In the lower state, it is further pressed into the inside of the liquid medicine reservoir.

[0011] Preferably, a first fitting portion is provided on the outer peripheral surface of the main body portion, and the plunger movement amount restricting member has a first fitting portion in a state where it is mounted on the main body portion. The second fitting portion that is fitted with each other, through the fitting between the first fitting portion and the second fitting portion, the plunger movement amount restricting member mounted on the main body portion is relative to The movement of the main body is restricted.

[0012] Preferably, the plunger movement amount restricting member has a clamping portion that engages with the plunger so as to be sandwiched from the outside of the plunger, and the plunger is provided on the other end side. There is a contraction part, and in a state where the pressing part is in contact with the stop part, the clamping part is at a position opposite to the contraction part, and the plunger movement limit member and the column The jammed state of the plug is released.

[0013] Preferably, the plunger has a function of releasing the first

A first contact part that engages between the fitting part and the second fitting part.

[0014] Preferably, the plunger has a second contact that is arranged between the stopper portion and the pressing portion in a state in which the plunger movement amount restricting member is engaged with the main body portion Part, by the plunger being inserted into the inside of the medicinal solution storage part, the second contact part is in contact with one of the stop part and the main body part, and is directed by the plunger The press-fitting of the inside of the medicinal solution storage portion and the state in which the plunger is in contact with the stop portion and the main body portion are released.

[00Inventive effect

[0016] According to the present invention, it is possible to obtain a nasal cavity administration container that can more simply and appropriately supply a medicinal solution when the medicinal solution is supplied to the left and right nasal cavities.

Description of the drawings

[0017] FIG. 1 is a perspective view showing a nasal cavity administration container in Embodiment 1.

[0018] FIG. 2 is a front view of the nasal cavity administration container in Embodiment 1, and is a view in the direction of arrow II in FIG. 1.

[0019] FIG. 3 is a side view showing the nasal cavity administration container in Embodiment 1, and is a view in the direction of arrow III in FIG. 1.

4 is a cross-sectional view taken along line IV-IV in FIG. 2.

[0021] FIG. 5 is a perspective view showing a state in which a part of the nasal cavity administration container in Embodiment 1 is disassembled (the plunger movement amount restriction member is removed from the main body).

[0022] FIG. 6 is a cross-sectional view taken along line VI-VI in FIG. 5.

[0023] FIG. 7 is a cross-sectional view showing a first administration preparation state of the nasal cavity administration container in Embodiment 1.

[0024] FIG. 8 is a cross-sectional view showing a first administration start state of the nasal cavity administration container in Embodiment 1.

[0025] FIG. 9 is a cross-sectional view showing a first administration completion state of the nasal cavity administration container in Embodiment 1. [0026] FIG. 10 is a cross-sectional view showing a second preparation state of the nasal cavity administration container in the first embodiment.

[0027] FIG. 11 is a cross-sectional view showing a second administration start state of the nasal cavity administration container in Embodiment 1.

[0028] FIG. 12 is a cross-sectional view showing a second administration completion state of the nasal cavity administration container in Embodiment 1.

[0029] FIG. 13 is a perspective view showing a nasal cavity administration container in Embodiment 2.

14 is a perspective view showing a state in which a part of the nasal cavity administration container in Embodiment 2 is disassembled (the plunger movement amount restriction member is removed from the main body).

15 is a side view showing the nasal cavity administration container in Embodiment 2. [0031] FIG.

16 is a first perspective view showing a state in which a part of the nasal cavity administration container in Embodiment 3 is disassembled (the plunger movement amount restriction member is removed from the main body).

[0033] FIG. 17 is a second perspective view showing a state in which a part of the nasal cavity administration container in Embodiment 3 is disassembled (the plunger movement amount restriction member is removed from the main body).

[0034] FIG. 18 is a side view showing a nasal cavity administration container in Embodiment 3.

[0035] FIG. 19 is a perspective view showing a nasal cavity administration container in Embodiment 4.

[0036] FIG. 20 is a cross-sectional view taken along the line XX-XX in FIG. 19.

21 is a cross-sectional view showing the state of the nasal cavity administration container in the fourth embodiment when assembled.

[0038] FIG. 22 is a first perspective view showing the nasal cavity administration container in the fifth embodiment.

[0039] FIG. 23 is a second perspective view showing the nasal cavity administration container in the fifth embodiment.

[0040] FIG. 24 is a perspective view showing a state in which the nasal cavity administration container in the fifth embodiment is disassembled.

[0041] FIG. 25 is a perspective view showing a state in which the plunger movement amount restricting member and the finger grip portion included in the nasal cavity medication container in the fifth embodiment are assembled to each other.

[0042] FIG. 26 is a perspective view showing a finger grip included in the nasal cavity medication container in the fifth embodiment.

[0043] FIG. 27 is a cross-sectional view showing the nasal cavity administration container in the fifth embodiment when assembled.

[0044] FIG. 28 is a cross-sectional view showing the nasal cavity administration container in the fifth embodiment in a first preparation state for administration.

29 is a cross-sectional view showing a first administration start state of the nasal cavity administration container in Embodiment 5. [0045] FIG.

[0046] FIG. 30 is a cross-sectional view showing a first administration completion state of the nasal cavity administration container in the fifth embodiment.

[0047] FIG. 31 is a cross-sectional view showing a second administration preparation state of the nasal cavity administration container in the fifth embodiment.

32 is a cross-sectional view showing a second administration start state of the nasal cavity administration container in Embodiment 5. [0048] FIG.

[0049] FIG. 33 is a cross-sectional view showing a second administration completion state of the nasal cavity administration container in the fifth embodiment.

Detailed ways

[0050] Hereinafter, each embodiment based on the present invention will be described with reference to the drawings. When referring to the number, number, etc. in the description of each embodiment, the scope of the present invention is not necessarily limited to the number, number, etc., unless otherwise specified. In the description of the respective embodiments, the same reference signs are sometimes given to the same components and corresponding components without overlapping descriptions.

[0051] [Embodiment 1]

[0052] (Constitution of nasal cavity administration container 100)

[0053] Hereinafter, the configuration of the nasal cavity administration container 100 in this embodiment will be described with reference to FIGS. 1 to 6.

[0054] FIG. 1 is a perspective view showing a nasal cavity administration container 100. FIG. 2 is a front view showing the nasal cavity medication container 100, and is a view in the direction of arrow II in FIG. 1. Fig. 3 is a side view showing the nasal cavity drug delivery container 100, and is a view in the direction of arrow III in Fig. 1.

[0055] As shown in FIGS. 1 to 3, the nasal cavity medication container 100 includes a main body 30 and a plunger movement amount restricting member 40. The main body 30 includes a liquid medicine reservoir 10 and a plunger 20.

[0056] (Medicinal Solution Storage Unit 10)

[0057] The medicinal solution storage portion 10 is composed of a cylinder 11 and a finger grip portion 14. The cylinder 11 is formed into a hollow substantially cylindrical shape. A plunger 20 and a sealing plug 28 which will be described later are inserted into the cylinder 11. One end of the cylinder 11 constitutes one end 12 of the medicinal solution reservoir 10. A nozzle 12N (syringe nozzle) is formed on the side of one end 12 of the medicinal solution reservoir 10. A spray nozzle 12M that communicates with the inside of the cylindrical body 11 via a nozzle 12N is attached to the one end 12 side of the medicinal solution reservoir 10 (see FIG. 1 ). Although the spray nozzle 12M shown in FIG. 1 is not shown in other drawings, in this embodiment and the following embodiments, the spray nozzle 12M is in a state of being attached to the cylinder 11. The cylinder 11 and the spray nozzle 12M may be formed integrally with each other, or may be formed as separate bodies as in the present embodiment and then assembled with each other.

4 is a cross-sectional view taken along the line IV-IV in FIG. 2. As shown in Fig. 4 (and Fig. 1), on the other end side of the cylinder 11, an annular flange portion HR bulging outward in the cylinder diameter direction is provided-on the inner side of the flange portion 11R is formed to communicate with the cylinder 11. Internal opening 11H (refer to FIG. 4).

[0059] The finger grip portion 14 is provided with a cutout portion 14U corresponding to the outer shape of the flange portion 11R (see also FIG. 1). The notch portion 14U communicates with an opening portion 14J that penetrates to the outer edge of the finger grip portion 14. The finger grip portion 14 is sandwiched between the flange portion 11R, and is attached to the flange portion 11R by frictional engagement with the flange portion 11R.

[0060] The finger grip 14 is also provided with an opening 14H for allowing the plunger 20 and the sealing plug 28 to pass therethrough (refer to FIG. 4). The hanging part 15 is provided continuously with the opening part 14H so that it may hang down. The hanging portion 15 is formed into a substantially half-cylindrical shape. The front end of the hanging portion 15 in the vertical downward direction constitutes the other end 13 of the medicinal solution reservoir 10. On the other end 13 side of the medicinal solution reservoir 10, an opening 13Ho for the plunger 20 and the sealing plug 28 to pass therethrough is formed

[0061] (Plunger 20)

[0062] FIG. 5 is a perspective view showing a state in which a part of the nasal cavity medication container 100 is disassembled (the plunger movement amount restricting member 40 is removed from the main body 30). As shown in FIG. 5 (and FIG. 4), the plunger 20 has a substantially rod shape. The plunger 20 has four thin-plate-shaped ribs 21.

[0063] The four ribs 21 extend along the length direction of the plunger 20 from one end 22 (refer to FIG. 4) to the other end 23 (refer to FIG. 4) of the plunger 20. As shown in FIG. 5, the four ribs 21 are arranged at 90° intervals, and are erected to the outside so as to be orthogonal to the longitudinal direction of the plunger 20.

[0064] Referring again to FIG. 4, a rubber sealing plug 28 is provided at one end 22 of the plunger 20. A disc-shaped pressing portion 23P is provided at the other end 23 of the plunger 20_OAs described above, the plunger 20 is inserted into the medicinal solution reservoir 10 (cylinder body 11) from the one end 22 side and the sealing plug 28 through the opening 13H of the medicinal solution reservoir 10 (cylinder body 11).

[0065] A constriction 26 is provided on the other end 23 side of the plunger 20 in this embodiment. The height of the constricted portion 26 (the dimension in the direction orthogonal to the longitudinal direction of the plunger 20 (the left-right direction on the paper surface of FIG. 4 )) is set relatively lower than the height of the front end portion 24 in the erecting direction of each rib 21. In other words, each rib 21 is reduced in the constricted portion 26.

[0066] In each of the four ribs 21, a contact portion 25 (second contact portion) is provided between the front end portion 24 and the constricted portion 26. In addition, the contact portion 25 can be provided as required. When the contact portion 25 is provided between the front end portion 24 and the contraction portion 26, the contact portion 25 is provided so as to protrude from the front end portion 24 of the rib 21 in a direction orthogonal to the longitudinal direction of the plunger 20. The front end portion of the contact portion 25 in the protruding direction is slightly outside the inner diameter (in the left-right direction of the paper surface of FIG. 4) of the hanging portion 15 of the finger grip portion 14. More details of the contact portion 25 and the contraction portion 26 will be described later.

[0067] (Plunger Movement Amount Restricting Member 40)

[0068] Referring again to FIG. 5, the plunger movement amount restricting member 40 includes a grip portion 41, a stopper portion 42, and a stopper portion 43. The stopper portion 42 and the stopper portion 43 are formed so as to be continuous from the end of the flat plate-shaped grip portion 41. The stopper portion 42 and the stopper portion 43 are formed symmetrically with the grip portion 41 interposed therebetween, and have a substantially half-cylindrical shape as a whole.

[0069] FIG. 6 is a cross-sectional view taken along line VI-VI in FIG. 5. As shown in FIG. 6, a clamping portion 42E is provided at the front end of the stopper 42. The clamping portion 42E is formed so as to be folded back inward from the front end of the stopper 42. A clamping portion 43E is provided at the front end of the stop portion 43. The clamping portion 43E is also formed so as to be folded back inward from the front end of the stop portion 43.

[0070] The interval L1 between the clamping portion 42E and the clamping portion 43E is set to be slightly smaller than the interval L2 between the front end portions 24 in the erecting direction of the rib 21 (interval L1<interval L2)_oThe plunger movement amount restricting member 40 can be engaged with the plunger 20 so as to sandwich the rib 21 (the front end 24 of the rib 21) of the plunger 20 from the outside by the clamping portions 42E and 43E.

[0071] On the other hand, the interval L1 between the clamping portion 42E and the clamping portion 43E is set to be slightly larger than the interval L3 between the front ends of the contraction portion 26 (interval L1>interval L3). In addition, as shown in FIG. 4, the dimension H1 of the clamping portions 42E and 43E in the longitudinal direction is set to be slightly smaller than the dimension H2 of the contraction portion 26 of the plunger 20 in the same direction (dimension H1<dimension H2). In a state where the clamping portions 42E. 43E and the contraction portion 26 are arranged to face each other, the plunger movement amount restricting member 40 is not engaged with the plunger 20.

[0072] As shown in FIGS. 5 and 6, a long groove 40M may be provided on the inner peripheral side of the stopper 42 and the stopper 43. Long slot

The shape of 40M is formed in a manner corresponding to the shape of the rib 21 of the plunger 20. In the state where the plunger movement restriction member 40 is attached to the plunger 20 (the state where the clamping portion 42E.43E of the plunger movement restriction member 40 and the rib 21 of the plunger 20 are engaged with each other), the rib The mutual fitting between the front end portion 24 of the portion 21 and the long groove 40M can suppress or prevent the rotation of the plunger movement amount restricting member 40 relative to the plunger 20. In addition, a rib 40Y (refer to FIG. 6) may be provided inside the long groove 40M (the operation of the rib 40Y will be described later).

[0073] (Assembly of the nasal cavity administration container 100)

[0074] Referring again to FIG. 4, when the nasal cavity administration container 100 is assembled, first, the sealing plug 28 is inserted into the cylinder 11 through the opening 11H of the cylinder 11. It is also possible to install a rubber cap or the like on one end 12 of the cylinder 11 before the sealing plug 28 is inserted into the inside of the cylinder 11, and to fill the inside of the cylinder Π with a liquid medicine in this state.

[0075] After filling the inside of the cylinder 11 with a medicinal solution as needed, the plunger 20 is installed on the sealing plug 28. The finger grip 14 is attached to the flange portion 11R of the cylinder 11. As described above, the finger gripping portion 14 is sandwiched between the flange portion 11R, and is attached to the flange portion 11R by friction engagement.

[0076] Then, the plunger movement amount restricting member 40 is mounted on the plunger 20 (refer to arrow AR40). When the plunger movement amount restricting member 40 is attached to the plunger 20, the plunger movement amount restricting member 40 is brought close to the finger grip portion 14. The stopper portions 42, 43 of the plunger movement amount restricting member 40 are slightly elastically deformed outward due to the engagement of the clamping portions 42E. 43E with the rib 21.

[0077] The stopper portions 42, 43 pass over the rib 21 by the clamping portions 42E. 43E to engage with the plunger 20. In addition, as described above, a spray nozzle 12M (refer to FIG. 1) is installed at one end 12 of the cylinder 11. In this way, the nasal cavity administration container 100 is assembled. [0078] In addition, the plunger movement amount restricting member 40 may be attached to the main body 30 (the plunger 20) in the following manner. First, the plunger 20 is inserted into the medicinal solution storage portion 10 so that the contact portion 25 of the plunger 20 is in contact with the other end 13 of the hanging portion 15. In a state where the relative positional relationship between the medicinal solution storage portion 10 and the plunger 20 is fixed, the contraction portion 26 of the plunger 20 and the stopper portions 42, 43 of the plunger movement amount restricting member 40 are arranged so as to face each other. Configuration. The plunger movement amount restricting member 40 and the plunger 20 are arranged so as to be adjacent to each other such that the stoppers 42 and 43 of the plunger movement amount restricting member 40 surround the outer periphery of the contraction portion 26.

[0079] Next, in a state where the relative positional relationship between the plunger movement restriction member 40 and the medicinal solution reservoir 10 is fixed, the plunger 20 is moved in a direction away from the medicinal solution reservoir 10. When the contact portion 25 of the plunger 20 passes inside the stopper portions 42, 43 of the plunger movement amount restricting member 40, the stopper portions 42, 43 are slightly elastically deformed outward. The contact portion 25 passes the end inside the stop portion 42.43, and the same state as that shown in FIG. 4 is obtained. In this way, the nasal cavity drug delivery container 100 can also be assembled.

[0080] Referring again to FIG. 1, in the assembled state of the nasal administration container 100, the stopper 42.43 of the plunger movement limit member 40 is arranged on the pressing portion 23P of the plunger 20 and the liquid medicine storage portion 10 (finger clip Between the openings 13H of the holding portion 14). The plunger movement amount restriction member 40 is engaged with the main body portion 30 (specifically, the rib 21 of the plunger 20) by the clamping portions 42E and 43E. The contact portion 25 of the plunger 20 is arranged between the stopper portion 42.43 of the plunger movement amount restricting member 40 and the pressing portion 23P of the plunger 20.

[0081] As described above, in the nasal cavity administration container 100, the relationship between the interval L1 in FIG. 6 <interval L2, and interval L1 in FIG. 6>, the interval L3, and the size H1<size H2 in FIG. 4 is established. With this configuration, it is possible to release the plunger movement restriction member 40 and the main body only in a state (the state shown in FIG. 9) where the pressing portion 23P of the plunger 20 is in contact with the stopper portion 42.43 of the plunger movement restriction member 40. The details of the engagement state of the portion 30 will be described later with reference to FIG. 9.

[0082] (Action of the nasal cavity drug delivery container 100)

[0083] Hereinafter, the operation of the nasal cavity administration container 100 will be described with reference to FIGS. 7 to 12. The nasal cavity administration container 100 is sequentially transferred to the following various states: the first administration preparation state S11 (refer to FIG. 7), the first administration start state S12 (refer to FIG. 8), and the first administration completion state S13 (refer to FIG. 9) The second administration preparation state S14 (refer to FIG. 10), the second administration start state S15 (refer to FIG. 11), and the second administration completion state S16 (refer to FIG. 12).

[0084] The first administration of the medicinal solution 60 is performed through the first administration preparation state S11, the first administration start state S12, and the first administration completion state S13. The second administration of the medicinal solution 60 is performed through the second administration preparation state S14, the second administration start state S15, and the second administration completion state S16. The details will be described below.

[0085] (First dosing preparation state S11)

[0086] Referring to FIG. 7, the nasal cavity administration container 100 is in a state where the assembly is completed, and the medicinal solution 60 is injected (or inhaled) from the nozzle 12N side (the state shown in FIG. 7). With the completion of the injection of the medicinal solution 60, the nasal cavity administration container 100 shifts to the first administration preparation state S1L. In some cases, at this time, the air 62 enters the side of one end 12 of the medicinal solution storage portion 10 (the cylinder 11).

[0087] (First administration start state S12)

[0088] With reference to FIG. 8, for the purpose of regulating the amount of the medicinal solution 60 to be administered to the nasal cavity to a predetermined value and (as necessary) expelling the air entering the medicinal solution reservoir 10 (the cylinder 11) as the purpose, the implementation of " "Priming" is the action.

[0089] Specifically, the plunger 20 is inserted into the medicinal solution reservoir 10 (cylinder body 11) (see arrow AR1). The plunger 20 and the sealing plug 28 slide against the inside of the cylinder 11 and enter the inside of the cylinder 11 until the contact portion 25 of the plunger 20 contacts the stopper portions 42, 43 of the plunger movement restriction member 40 . On the inner side of the stopper portions 42, 43, ribs that contact the contact portion 25 when the plunger 20 is inserted into the cylinder 11 (the rib 40Υ in FIG. 6 described above) may be provided._οThrough the provision of the rib 40Y, the contact portion 25 of the plunger 20 is in contact with this rib 40Y_οThe plunger 20 enters the inside of the cylinder 11 until the contact occurs.

[0090] The contact portion 25 of the plunger 20 is in contact with the stopper portions 42, 43 (or the rib 40Y provided on the inner side of the stopper portion 42, 43) of the plunger movement amount restricting member 40, and the plunger movement amount The movement of the restriction member 40 with respect to the main body portion 30 is stopped (the state shown in FIG. 8 ). In the present embodiment, the stoppers 42 and 43 correspond to one of the stoppers 42 and 43 and the main body 30.

[0091] As the movement of the plunger movement amount restricting member 40 with respect to the main body 30 is stopped, the nasal cavity administration container 100 shifts to the first administration start state S12. The air inside the medicinal solution reservoir 10 (the cylinder 11) is The amount of the medicinal liquid 60 that is extruded to the outside of the medicinal liquid storage portion 10 to be supplied to the nasal cavity is regulated to a predetermined value ("priming" is implemented).

[0092] (The first administration completion state S13)

[0093] Referring to FIG. 9, after the amount of the medicinal solution 60 to be supplied to the nasal cavity is regulated to a predetermined value, the spray nozzle 12M (refer to FIG. 1) attached to the nozzle 12N side is arranged in one nasal cavity. In this state, the plunger 20 is strongly pressed into the liquid medicine reservoir 10 (cylinder body 11) by the pressing portion 23P (refer to arrow AR2)_O

[0094] As the plunger 20 is swiftly pressed in, the contact portion 25 of the plunger 20 contacts the stopper portion 42, 43 (or the rib provided inside the stopper portion 42, 43) of the plunger movement amount restricting member 40 40Y) is released. As the contact portion 25 enters the inside of the stopper portions 42 and 43, the plunger 20 advances inside the liquid medicine storage portion 10. The sealing plug 28 enters the inside of the medicinal solution storage portion 10 due to the pressing of the plunger 20. In addition, because ribs 40Y are provided inside the stopper portions 42, 43, and the contact portion 25 and the rib 40Y are engaged with a pressing force of a predetermined value or more, it is possible to stabilize the nasal cavity at high pressure from the beginning of spraying. spray.

[0095] The liquid medicine 60 inside the liquid medicine storage portion 10 is sprayed from the spray nozzle 12M (refer to FIG. 1) due to the movement of the sealing plug 28. From the spray nozzle 12M to one nasal cavity, the medicinal solution 60 is administered in a mist form. The plunger 20 advances until the pressing portion 23P is in contact with

The plunger movement amount restricting member 40 reaches the lower end of the stopper 42.43.

[0096] When the pressing portion 23P comes into contact with the lower ends of the stoppers 42, 43 of the plunger movement amount restricting member 40, the movement of the plunger 20 with respect to the medicinal solution storage portion 10 is stopped (the state shown in FIG. 9). As the movement of the plunger 20 stops, the first administration is completed, and the nasal cavity administration container 100 shifts to the first administration completion state S13_oThe stroke amount of the plunger 20 with respect to the medicinal solution reservoir 10 defines the first dose of the medicinal solution 60.

[0097] (Second Dosing Preparation State S14)

[0098] Referring to FIG. 10, in the state where the first administration of the drug solution 60 is completed (the state shown in FIG. 9), the gripping portion 42E.43E of the plunger movement restriction member 40 and the constriction portion 26 of the plunger 20 relatively. The engagement state of the plunger movement amount restricting member 40 and the plunger 20 (rib portion 21) is released by the arrangement relationship between the clamping portions 42E. 43E and the contraction portion 26.

[0099] In order to perform the second administration of the medicinal solution 60, as indicated by arrow AR3, the plunger movement amount restricting member 40 is detached from the main body 30 (state shown in FIG. 10). As the plunger movement amount restricting member 40 is removed from the main body 30, the nasal cavity administration container 100 shifts to the second administration preparation state S14o

[0100] (Second administration start state S15)

11, after the plunger movement amount restricting member 40 is removed from the main body 30 (second administration preparation state S14), the spray nozzle 12M on the nozzle 12N side of the nasal administration container 100 is installed (refer to Figure 1) is deployed in another nasal cavity. Thereby, the nasal cavity administration container 100 shifts to the second administration start state S15_o

[0102] (Second administration completion state S16)

12, after the spray nozzle 12M (refer to FIG. 1) of the nasal cavity administration container 100 is placed in the other nasal cavity, the plunger 20 is directed toward the medicinal solution reservoir 10 (the cylinder 11) by the pressing portion 23P Push in further inside (refer to arrow AR4). The plunger 20 advances inside the medicinal solution storage part 10. The sealing plug 28 further enters the inside of the medicinal solution storage portion 10 due to the pressing of the plunger 20.

[0104] A rib having the same function as the aforementioned rib 14Y (refer to FIG. 6) may be provided on the inner side of the hanging portion 15 of the finger grip portion 14. When the plunger 20 is further pressed into the inside of the cylinder 11, the contact portion 25 is engaged with this rib. Since the contact portion 25 is engaged with this rib to have a pressing force equal to or higher than a predetermined value, it is possible to stably spray into the nasal cavity at a high pressure from the start of spraying.

[0105] The liquid medicine 60 inside the liquid medicine reservoir 10 is sprayed from the spray nozzle 12M (refer to FIG. 1) due to the movement of the sealing plug 28. From the spray nozzle 12M to the other nasal cavity, the medicinal solution 60 is administered in a mist form. The plunger 20 advances until the sealing plug 28 contacts the upper end inside the cylinder 11. The plunger 20 may also be configured to advance until the pressing portion 23P contacts the lower end (the other end 13) of the hanging portion 15 of the finger grip portion 14.

[0106] As the plunger 20 advances until the sealing plug 28 comes into contact with the upper end of the inside of the cylinder 11, the movement of the plunger 20 with respect to the liquid medicine reservoir 10 is stopped (the state shown in FIG. 12). As the movement of the plunger 20 stops, the second administration is completed, and the nasal cavity administration container 100 shifts to the second administration completion state S16_oThe stroke amount of the plunger 20 with respect to the medicinal solution reservoir 10 defines the second administration amount of the medicinal solution 60. The nasal cavity administration container 100 operates in the above manner, and the administration of the medicinal solution 60 by the nasal cavity administration container 100 is implemented in the above manner.

[0107] (Action, Effect)

[0108] In the nasal cavity medication container 100, as described above, the contact portion 25 is provided on the plunger 20, and the plunger movement amount restricting member 40 is mounted on the plunger 20 of the main body portion 30. The contact portion 25 of the plunger 20 is in contact with the stopper portions 42, 43 of the plunger movement amount restricting member 40, and the nasal cavity administration container 100 can be easily transferred from the first administration preparation state S11 (refer to FIG. 7) The first administration start state S12 (refer to FIG. 8). In addition, as described above, the contact portion 25 can be provided as required.

Set.

[0109] In the nasal cavity administration container 100, as described above, the first administration preparation state S11 (refer to FIG. 7), the first administration start state S12 (refer to FIG. 8), and the first administration completion state S13 (Refer to FIG. 9 ), the plunger movement amount restricting member 40 is always engaged with the main body 30. Only in a state where the pressing portion 23P of the plunger 20 is in contact with the stopper portion 42.43 of the plunger movement amount restricting member 40, the state in which the plunger movement amount restricting member 40 is engaged with the main body portion 30 can be released.

[0110] Until the first administration of the medicinal solution 60 is completed, since the plunger movement amount restricting member 40 is not removed from the main body 30, the nasal cavity administration container 100 can reliably administer an appropriate amount of administration. At the same time that the first administration of the medicinal solution 60 is completed, the plunger movement amount restricting member 40 can be easily detached from the main body portion 30 by the contraction portion 26 of the plunger 20. The nasal cavity administration container 100 is highly convenient in preparing for the second administration after the first administration is completed.

[0111] (Other Configurations of Embodiment 1)

[0112] At the start of the second administration of the medicinal solution 60 (the second administration start state S15 (see FIG. 11)), the contact portion 25 of the plunger 20 may also be frictionally engaged with the inner peripheral surface of the hanging portion 15. Way to constitute. This configuration is obtained by making the protruding size of the contact portion 25 slightly larger than the inner diameter size of the hanging portion 15.

[0113] According to this configuration, at the start of the second administration, in order to release the frictional engagement between the contact portion 25 and the inner peripheral surface of the pendant portion 15, the pressing portion 23P receives a large pressing force. After the frictional engagement is released by a large pressing force, the plunger 20 can be rapidly pushed into the liquid medicine reservoir 10 in this state. The medicinal solution 60 can also form a good mist in the second administration and can be administered appropriately.

[0114] Also, at the start of the first administration of the medicinal solution 60, the contact portion 25 may also be configured to frictionally engage with the inner peripheral surface of the stopper portion 42.43. According to this configuration, at the start of the first administration, in order to release the frictional engagement between the contact portion 25 and the inner peripheral surfaces of the stoppers 42, 43, the pressing portion 23P receives a large pressing force. After the frictional engagement is released by a large pressing force, the plunger 20 can be rapidly pushed into the liquid medicine reservoir 10 in this state. The medicinal solution 60 can also form a good mist in the first administration and can be administered appropriately.

[0115] [Embodiment 2]

[0116] Next, the nasal cavity administration container 101 in this embodiment will be described with reference to FIGS. 13 to 15. The nasal cavity administration container 101 is different from the nasal cavity administration container 100 (refer to FIG. 1) in the first embodiment described above in the following points.

[0117] FIG. 13 is a perspective view showing the nasal cavity administration container 101. As shown in FIG. 13, the nasal cavity administration container 101 includes a main body portion 30 and a plunger movement amount restricting member 40A. The main body portion 30 includes a medicinal solution storage portion 10 and a plunger 20.

14 is a perspective view showing a state in which a part of the nasal cavity administration container 101 is disassembled (the plunger movement amount restriction member 40A is removed from the main body 30). As shown in FIG. 14, the medicinal solution storage portion 10 in the present embodiment includes a finger grip portion 14A. A convex portion 15P (first fitting portion) is provided on the outer peripheral portion of the hanging portion 15 of the finger grip portion 14A.

[0119] The plunger movement amount restricting member 40A in this embodiment is provided with an enclosing portion 46 so as to abut the stopper 42 and the stopper 43 (not shown). The surrounding portion 46 is formed in a semi-cylindrical shape. The surrounding portion 46 is provided with an opening 46C (a second fitting portion) having a shape corresponding to the shape of the convex portion 15P provided on the hanging portion 15.

15 is a side view showing the nasal cavity administration container 101. As shown in Figure 15, the plunger movement limit member 40A is mounted on the main body 30 (refer to arrow AR40A)_oIn this state, the convex portion 15P and the opening 46C are fitted with each other. By this fitting, the movement of the plunger movement amount restricting member 40A with respect to the main body portion 30 in the direction of the arrow AR41A is restricted.

[0121] In addition, as in the first embodiment described above, the plunger movement amount restricting member 40A may be attached to the main body 30 in a state where the contact portion 25 of the plunger 20 is in contact with the other end 13 of the hanging portion 15. At this time, through the plunger movement limit

For the mounting of the control member 40A on the main body portion 30, the convex portion 15P and the opening portion 46C are fitted with each other. After the protrusion 15P is fitted with the opening 46C, the plunger 20 moves in a direction away from the medicinal solution storage portion 10. This assembly can also obtain the state shown in Figure 13.

[0122] In addition, before the finger grip portion 14A is mounted on the flange portion 11R, the plunger movement amount restricting member 40A and the finger grip portion 14A may be assembled to each other in advance. When the plunger movement restriction member 40A and the finger grip portion 14A are integrated, the plunger movement restriction member 40A and the finger grip portion 14A can be easily mounted on the cylinder 11 (flange portion 11R) .

[0123] In the nasal cavity administration container 101, as in the above-mentioned first embodiment, the first administration and the second administration are respectively administered. In the first administration, the movement of the plunger movement amount restricting member 40A relative to the main body portion 30 in the arrow AR41A direction (refer to FIG. 15) is restricted. Since the plunger movement amount restricting member 40A is fixed to the main body 30, the nasal cavity administration container 101 has good operational stability when the plunger 20 is pushed into the medicinal solution storage section 10.

[0124] [Embodiment 3]

[0125] Next, the nasal cavity administration container 102 in this embodiment will be described with reference to FIGS. 16 to 18. The nasal cavity administration container 102 is different from the nasal cavity administration container 100 (refer to FIG. 1) in the first embodiment described above in the following points.

16 is a first perspective view showing a state in which a part of the nasal cavity medication container 102 is disassembled (the plunger movement amount restricting member 40B is removed from the main body 30). As shown in FIG. 16, the nasal cavity administration container 102 includes a main body portion 30 and a plunger movement amount restricting member 40Bo. The main body portion 30 includes a medicinal solution storage portion 10 and a plunger 20.

[0127] FIG. 17 is a second perspective view showing a state in which a part of the nasal cavity medication container 102 is disassembled (the plunger movement amount restricting member 40B is removed from the main body 30). As shown in FIG. 17, the medicinal solution storage part 10 in this embodiment includes the finger grip part 14Bo, and the recessed part 15C (1st fitting part) is provided in the outer peripheral part of the hanging part 15 of the finger grip part 14B.

[0128] In the plunger movement amount restricting member 40B in this embodiment, a convex portion 46P (second fitting portion) having a shape corresponding to the shape of the concave portion 15C provided in the hanging portion 15 is provided at the end surface 41T of the grip portion 41 ).

[0129] FIG. 18 is a side view showing the nasal cavity administration container 102. As shown in Figure 18, the plunger movement limit member 40B is attached to the main body 30 (refer to arrow AR40B)_oIn this state, the concave portion 15C and the convex portion 46P are fitted with each other. By this fitting, the movement of the plunger movement amount restricting member 40B with respect to the main body portion 30 in the arrow AR41B direction is restricted.

[0130] In addition, similar to the first embodiment described above, the plunger movement amount restricting member 40B may be attached to the main body portion 30 in a state where the contact portion 25 of the plunger 20 is in contact with the other end 13 of the hanging portion 15. At this time, by the attachment of the plunger movement amount restricting member 40B to the main body portion 30, the concave portion 15C and the convex portion 46P are fitted to each other. After the concave portion 15C and the convex portion 46P are fitted between, the plunger 20 moves in a direction away from the medicinal solution storage portion 10. This assembly can also obtain the state shown in FIG. 18.

[0131] In addition, before the finger grip portion 14B is attached to the flange portion 11R, the plunger movement amount restricting member 40B and the finger grip portion 14B may be assembled to each other in advance. In a state where the plunger movement restriction member 40B and the finger grip portion 14B are integrated, the plunger movement restriction member 40B and the finger grip portion 14B can be easily mounted on the cylinder 11 (flange portion 11R) .

[0132] In the nasal cavity administration container 102, the first administration and the second administration are respectively administered in the same manner as in the above-mentioned first embodiment. In the first administration, the movement of the plunger movement amount restricting member 40B relative to the main body portion 30 in the arrow AR41B direction (refer to FIG. 18) is restricted. As in the second embodiment described above, since the plunger movement amount restricting member 40B is fixed to the main body portion 30, the nasal cavity administration container 102 is stable in operation when the plunger 20 is pushed into the medicinal solution storage portion 10 it is good.

[Embodiment 4]

[0134] Next, the nasal cavity administration container 103 in this embodiment will be described with reference to FIGS. 19 to 21. The nasal cavity administration container 103 is different from the nasal cavity administration container 100 (refer to FIG. 1) in the first embodiment described above in the following points.

[0135] FIG. 19 is a perspective view showing the nasal cavity administration container 103. As shown in FIG. 19, the nasal cavity administration container 103 includes a main body portion 30 and a plunger movement amount restricting member 40. The main body portion 30 includes a medicinal solution storage portion 10 and a plunger 20.

[0136] FIG. 20 is a cross-sectional view taken along the line XX-XX in FIG. 19. As shown in FIG. 20, the medicinal solution storage portion 10 in the present embodiment includes the finger grip portion 14Co. The cut portion 14U of the finger grip portion 14C is cut so as to open the periphery of the flange portion 11R. In this embodiment, the flange portion 11R constitutes the first fitting portion.

[0137] The plunger movement amount restricting member 40C in this embodiment has a recessed portion 46K (a second fitting portion) whose shape corresponds to the shape of the flange portion 11R. The recessed portion 46K is fitted with the flange portion 11R in a state where the plunger movement amount restricting member 40C is attached to the main body portion 30.

21 is a cross-sectional view showing the nasal cavity administration container 103, which shows the state of the nasal cavity administration container 103 when assembled. As shown in FIG. 21, the plunger movement restriction member 40C is installed on the royal body 30 (refer to arrow AR40C). By installing the plunger movement restriction member 40C on the main body 30, the recess 46K and the flange 11R are mutually connected. Chimera. By this fitting, the movement of the plunger movement amount restricting member 40C with respect to the main body portion 30 in the arrow AR41C direction is restricted.

[0139] In addition, as in the first embodiment described above, the plunger movement amount restricting member 40C may be attached to the main body portion 30 in a state where the contact portion 25 of the plunger 20 is in contact with the other end 13 of the hanging portion 15. At this time, by mounting the plunger movement amount restricting member 40C on the main body portion 30, the recessed portion 46K and the flange portion 11R are fitted to each other. After fitting between the recessed portion 46K and the flange portion 11R, the plunger 20 moves in a direction away from the medicinal solution storage portion 10. This assembly can also obtain the state shown in Figure 18.

[0140] In addition, before the finger grip portion 14C is attached to the flange portion 11R, the plunger movement amount restricting member 40C and the finger grip portion 14C may be assembled with each other in advance. In a state where the plunger movement amount restriction member 40C and the finger grip portion 14C are integrated, the plunger movement amount restriction member 40C and the finger grip portion 14C can be easily attached to the cylinder 11 (flange portion 11R) .

[0141] In the nasal cavity administration container 103, as in the above-mentioned first embodiment, the first administration and the second administration are respectively administered. At the time of the first administration, the movement of the plunger movement amount restriction member 40C relative to the main body portion 30 in the arrow AR41C direction (refer to FIG. 21) is restricted. Similar to the above-mentioned Embodiments 2 and 3, since the plunger movement amount restricting member 40C is fixed to the main body portion 30, when the nasal cavity administration container 103 presses the plunger 20 into the medicinal solution reservoir 10, the operation is Good stability.

[0142] [Embodiment 5]

[0143] (Constitution of nasal cavity administration container 104)

[0144] Next, the configuration of the nasal cavity administration container 104 in this embodiment will be described with reference to FIGS. 22 to 27. FIG. 22 is a first perspective view showing the nasal cavity administration container 104. FIG. 23 is a second perspective view showing the nasal cavity administration container 104.

[0145] As shown in FIGS. 22 and 23, the nasal cavity administration container 104 includes a main body portion 30 and a plunger movement amount restricting member 40. The main body portion 30 includes a medicinal solution storage portion 10 and a plunger 20.

[0146] (Medicinal Solution Storage Unit 10)

[0147] The medicinal solution storage portion 10 is composed of a cylindrical body 11 and a finger grip portion 14D. The cylinder 11 is formed into a hollow substantially cylindrical shape. A plunger 20 and a sealing plug 28 described later are inserted into the cylinder π. One end of the cylinder 11 constitutes one end 12 of the liquid medicine reservoir 10. The nozzle 12No is formed on the side of one end 12 of the liquid medicine reservoir 10, as in the above-mentioned first embodiment.

A spray nozzle 12M (refer to FIG. 1) communicating with the inside of the cylinder 11 via a nozzle 12N is attached to the one end 12 side of the reservoir 10. The cylinder 11 and the spray nozzle 12M may be formed integrally with each other, or may be formed as separate bodies as in the present embodiment and then assembled with each other.

[0148] FIG. 24 is a perspective view showing a state in which the nasal cavity administration container 104 is disassembled. As in the first embodiment described above, a flange portion 11R that bulges outward in the cylindrical diameter direction is provided on the other end side of the cylindrical body 11. On the inner side of the flange portion 11R, an opening UHo communicating with the inside of the cylindrical body 11 is formed

[0149] The finger grip portion 14D is provided with a cutout portion 14U corresponding to the shape of the flange portion 11R. The notch portion 14U communicates with an opening 14J (see FIG. 22) penetrating the outer edge of the finger grip portion 14D. The finger grip portion 14D sandwiches the flange portion 11R, and is attached by frictional engagement with the flange portion 11R.

[0150] The finger grip 14D is also provided with an opening 14H for allowing the plunger 20 and the sealing plug 28 to pass through. It is continuous with the opening part 14H, and the hanging part 15 is provided so that it may hang down. The hanging portion 15 is formed in a cylindrical shape. The front end portion of the hanging portion 15 in the hanging direction constitutes the other end 13 of the medicinal solution storage portion 10 (refer to FIG. 22 ). An opening 13Ho for passing the plunger 20 and the sealing plug 28 is formed on the other end 13 side of the medicinal solution reservoir 10

[0151] FIG. 25 is a perspective view showing a state in which the plunger movement amount restricting member 40D and the finger grip portion 14D included in the nasal cavity medication container 104 are assembled to each other. As shown in FIG. 25, the hanging portion 15 in this embodiment is provided with four notches 15U extending in the longitudinal direction of the hanging portion 15. The four cut-out portions 15U are arranged at 90° intervals (see FIG. 26). The end side of the hanging portion 15 (the other end 13) is provided with the cut-out portion 15U in the hanging portion 15, so that it can be elastically deformed in the shape of a leaf spring.

[0152] An opening 15Q is also provided in the hanging portion 15 (refer also to FIG. 24). The shape of the opening 15Q corresponds to the shape of the hook 46J of the plunger movement amount restricting member 40D described later. A folded-back portion 15V (refer to FIG. 27) is provided inside the opening 15Q. The folded-back portion 15V is provided so as to bend to the inner diameter side of the hanging portion 15 and is inclined to the opening 15Q side.

[0153] FIG. 26 is a perspective view showing the finger grip portion 14D included in the nasal cavity medication container 104. By providing the cut-out portion 15U in the hanging portion 15, the end side (the other end 13 side) of the hanging portion 15 is divided into four parts. On the end side of the hanging portion 15 (the other end 13?0), two opposing locations are provided with projections 15T that are generally trapezoidal when viewed in cross section (also refer to FIG. 27) o

[0154] (Plunger 20)

[0155] Referring again to FIG. 24, the plunger 20 in this embodiment is formed in a substantially rod shape. The plunger 20 has four thin-plate-shaped ribs 21. The four ribs 21 extend from one end 22 to the other end 23 of the plunger 20 along the length direction of the plunger 20. The four ribs 21 are arranged at an interval of 90°, and are erected outward so as to be orthogonal to the longitudinal direction of the plunger 20.

[0156] A sealing plug 28 made of rubber is provided on the side of one end 22 of the plunger 20. A disc-shaped pressing portion 23P is provided at the other end 23 of the plunger 20_OAs described above, the plunger 20 is inserted into the medicinal solution reservoir 10 (cylinder body 11) from the one end 22 side together with the sealing plug 28 through the opening 13H of the medicinal solution reservoir 10 (cylinder body 11).

[0157] The plunger 20 in this embodiment is provided with a contact portion 27 (first contact portion), a contact portion 25D (second contact portion), and a contact portion 29. The contact portion 27 is formed in a disc shape. In addition, the contact portion 25D and the contact portion 29 can be provided as required. When the contact portion 25D and the contact portion 29 are provided on the plunger 20, both the contact portion 25D and the contact portion 29 are formed in a circular plate shape. The diameter of the contact portion 27 is configured to be smaller than the diameter of the contact portion 25D and the diameter of the contact portion 29. The diameter of the contact portion 25D and the diameter of the contact portion 29 are configured to be the same. The contact portion 27, the contact portion 25D, and the contact portion 29 are arranged in this order from the one end 22 side to the other end 23 side of the plunger 20, and are arranged at intervals. More details of the contact portion 27, the contact portion 25D, and the contact portion 29

The situation will be described later.

[0158] (Plunger Movement Amount Restricting Member 40D)

[0159] Referring again to FIGS. 24 and 25, the plunger movement amount restricting member 40D includes a grip 41, a stopper 42, a stopper 43, and a hook 46J (refer to FIG. 25) o stopper 42 and stopper 43 is formed in a continuous manner from the end of the grip 41. The stopper portion 42 and the stopper portion 43 are formed symmetrically with the grip portion 41 interposed therebetween, and have a substantially half-cylindrical shape as a whole.

[0160] As shown in FIG. 25, a hook portion 46J is provided on the inner peripheral surface of the stopper 42 and the stopper 43 that have a substantially half-cylindrical shape so as to protrude in an L-shape. As described above, the shape of the hook portion 46J corresponds to the shape of the opening portion 15Q (turn-back portion 15V) provided in the hanging portion 15 of the finger grip portion 14D. In a state where the nasal cavity medication container 104 (refer to FIGS. 22 and 23) is assembled, the hook portion 46J engages with the folded-back portion 15V (refer to FIG. 27) successively provided in the opening portion 15Q.

[0161] (Assembly of the nasal cavity administration container 104)

[0162] FIG. 27 is a cross-sectional view showing the nasal cavity administration container 104 when it is assembled. When the nasal cavity medication container 104 is assembled, first, the finger grip portion 14D is attached to the flange portion 11R of the cylinder 11 (see arrow AR14D). As described above, the finger grip portion 14D sandwiches the flange portion 11R, and is attached by frictional engagement with the flange portion 11R. Thus, the medicinal solution reservoir 10 (FIG. 22 and FIG. 23) is obtained. In addition, as described above, a spray nozzle 12M is installed at one end 12 of the cylinder 11 (refer to FIG. 1).

[0163] Next, the stopper portions 42, 43 of the plunger movement amount restricting member 40D are mounted so as to surround the outer periphery of the finger grip portion 14D. The hook portion 46J of the plunger movement amount restricting member 40D corresponds to the finger grip portion 14D Insert into the opening 15Q (refer to arrow AR40D) in such a way that the opening 15Q (turn-back 15V) is engaged with_o

[0164] Then, a plunger 20 with a sealing plug 28 installed at one end 22 is prepared. The sealing plug 28 and the plunger 20 are inserted into the cylinder 11 through the opening 13H of the other end 13 of the medicinal solution reservoir 10 and the opening 11H of the cylinder 11 (see arrow AR20). Thereby, the main body part 30 including the medicinal solution storage part 10 and the plunger 20 is obtained (refer FIG. 22 and FIG. 23).

[0165] In the assembled state of the nasal cavity administration container 104, the plunger movement restriction member 40D is engaged with the main body 30 (specifically, the opening 15Q and the folded-back portion of the finger grip portion 14D by the hook 46J). 15V) (refer to Figure 28). The contact portion 27 of the plunger 20 is arranged so as to face the tip portion of the hook 46J provided on the plunger movement limit member 40D (refer to FIG. 28). The contact portion 25D of the plunger 20 is arranged in accordance with the finger The protrusions 15T provided on the clamping portion 14D are arranged in such a way that they face each other (refer to FIG. 28) o

[0166] With this configuration, it is possible to release the plunger movement restriction member only in a state (the state shown in FIG. 30) where the pressing portion 23P of the plunger 20 is in contact with the stopper portion 42.43 of the plunger movement restriction member 40D. The details of the engagement state of the 40D and the main body portion 30 will be described later with reference to FIG. 30.

[0167] (Action of nasal cavity drug delivery container 104)

[0168] Next, the operation of the nasal cavity administration container 104 will be described with reference to FIGS. 28 to 33. The nasal cavity administration container 104 enters the following states in sequence: the first administration preparation state S21 (refer to FIG. 28), the first administration start state S22 (refer to FIG. 29), and the first administration completion state S23 (refer to FIG. 30), the second administration preparation state S24 (refer to FIG. 31), the second administration start state S25 (refer to FIG. 32), and the second administration completion state S26 (refer to FIG. 33).

[0169] The first administration of the medicinal solution 60 is performed through the first administration preparation state S21, the first administration start state S22, and the first administration completion state S23. The second administration of the medicinal solution 60 is performed through the second administration preparation state S24, the second administration start state S25, and the second administration completion state S26. The details are described below.

[0170] (First Dosing Preparation State S21)

[0171] Referring to FIG. 28, the nasal cavity administration container 104 is in the assembled state, and the medical solution 60 is injected (or inhaled) from the nozzle 12N side (the state shown in FIG. 28). With the completion of the injection of the medicinal solution 60, the nasal cavity administration container 104 shifts to the first administration preparation state S2L. In some cases, at this time, the air 62 enters the side of one end 12 of the medicinal solution reservoir 10 (the cylinder 11).

[0172] (First administration start state S22)

[0173] With reference to FIG. 29, for the purpose of regulating the amount of the medicinal solution 60 to be supplied to the nasal cavity to a predetermined value and (as necessary) expelling the air entering the medicinal solution reservoir 10 (the cylinder 11) as the purpose, the "start" is implemented. The action of "raising".

[0174] Specifically, the plunger 20 (see arrow AR1) is inserted into the medicinal solution reservoir 10 (cylinder body 11). The plunger 20 and the sealing plug 28 slide against the inside of the cylinder 11 and enter the inside of the cylinder 11 until the contact portion 25D of the plunger 20 touches the protrusion 15T of the finger grip 14D (the rear of the protrusion 15T). End).

[0175] When the contact portion 25D of the plunger 20 contacts the protruding portion 15T of the finger grip portion 14D, the movement of the plunger movement amount restricting member 40D relative to the main body portion 30 is stopped (the state shown in FIG. 29). In the present embodiment, the finger grip portion 14D constituting the main body portion 30 corresponds to "one of the stopper portions 42, 43 and the main body portion 30".

[0176] As the movement of the plunger movement amount restricting member 40D with respect to the main body portion 30 is stopped, the nasal cavity administration container 104 shifts to the first administration start state S22_OThe air inside the medicinal solution reservoir 10 (the cylinder 11) is squeezed out to the outside of the medicinal solution reservoir 10, and the amount of the medicinal solution 60 to be supplied to the nasal cavity is regulated to a predetermined value.

[0177] (The first administration completion state S23)

[0178] Referring to FIG. 30, after the amount of the medical solution 60 to be supplied to the nasal cavity is regulated to a predetermined value, the spray nozzle 12M (refer to FIG. 1) attached to the nozzle 12N side is arranged in one nasal cavity. In this state, by the pressing portion 23P, the plunger 20 is strongly pressed into the inside of the medicinal solution storage portion 10 (cylinder body 11) (refer to arrow AR2)_O

[0179] When the plunger 20 is pushed in rapidly, the state in which the contact portion 25D of the plunger 20 is in contact with the protrusion 15T of the finger grip portion 14D is released.

[0180] At the start of the first administration of the medicinal solution 60, the contact portion 25D of the plunger 20 may also be configured to be frictionally engaged with the inner peripheral surface of the protruding portion 15T. This structure is obtained by making the protrusion size of the contact portion 25D slightly larger than the inner diameter size of the protrusion portion 15T.

[0181] According to this configuration, at the start of the first administration, in order to release the frictional engagement between the contact portion 25D and the protruding portion 15T, the pressing portion 23P receives a large pressing force. After the frictional engagement is released by a large pressing force, the plunger 20 can be rapidly pushed into the liquid medicine reservoir 10 in this state. The medicinal solution 60 can form a good mist in the first administration and is appropriately administered.

[0182] While the contact portion 25D enters the inside of the protruding portion 15T, the plunger 20 advances inside the medicinal solution storage portion 10. At this time, the hanging portion 15 divided into four by the arrangement of the notch 15U is slightly elastically deformed to the outside. The sealing plug 28 is pressed by the plunger 20 and enters the inside of the liquid medicine reservoir 10.

[0183] In this way, the medicinal solution 60 inside the medicinal solution reservoir 10 is sprayed from the spray nozzle 12M (refer to FIG. 1) by the movement of the sealing plug 28. From the spray nozzle 12M to one nasal cavity, the medicinal solution 60 is administered in a mist form. The plunger 20 advances until the pressing portion 23P contacts the lower end of the stopper 42.43 of the plunger movement amount restricting member 40D.

[0184] When the pressing portion 23P comes into contact with the lower ends of the stoppers 42, 43 of the plunger movement amount restricting member 40D, the movement of the plunger 20 relative to the medicinal solution storage portion 10 is stopped (the state shown in FIG. 30). At this time, the contact portion 29 is in contact with the rear end of the protruding portion 15T. As the movement of the plunger 20 stops, the first administration is completed, and the nasal cavity administration container 104 shifts to the first administration completion state S23_OThe stroke amount of the plunger 20 with respect to the medicinal solution reservoir 10 defines the first dose of the medicinal solution 60.

[0185] Here, as indicated by the arrow AR2a, while the pressing portion 23P is in contact with the lower ends of the stopper portions 42, 43 of the plunger movement amount restricting member 40D, the contact portion 27 provided on the plunger 20 is in contact with The plunger movement amount restriction member 40D is attached to the hook 46J. The contact portion 27 of the plunger 20 elastically deforms the hook portion 46J in a direction away from the turn-back portion 15V in such a manner that the engagement state of the hook portion 46J with the opening portion 15Q and the turn-back portion 15V is released.

[0186] By this elastic deformation, in the state where the first administration of the medicinal solution 60 is completed (the state shown in FIG. 30), the engagement state of the hook portion 46J with the opening portion 15Q and the folded-back portion 15V is released. In this way, the nasal cavity administration container 104 can release the restriction of the plunger movement amount only when the pressing portion 23P of the plunger 20 is in contact with the stopper portions 42, 43 of the plunger movement amount restricting member 40D (the state shown in FIG. 30). The engagement state of the component 40D and the main body 30.

[0187] (Second Dosing Preparation State S24)

[0188] Referring to FIG. 31, in order to perform the second administration of the medicinal solution 60, as indicated by arrow AR3, the plunger movement amount restricting member 40D is removed from the main body portion 30 (state shown in FIG. 31). By removing the plunger movement amount restricting member 40D from the main body 30, the nasal cavity administration container 104 shifts to the second administration preparation state S24_O

[0189] (Second administration start state S25)

32, after the plunger movement amount restricting member 40D is removed from the main body 30 (second administration preparation state S24), the spray nozzle 12M attached to the nozzle 12N side of the nasal cavity administration container 104 ( Refer to Figure 1) is configured into another nasal cavity. Thereby, the nasal cavity administration container 104 shifts to the second administration start state S25.

[0191] (Second administration completion state S26)

[0192] Referring to FIG. 33, after the spray nozzle 12M (refer to FIG. 1) of the nasal cavity administration container 104 is placed in the other nasal cavity, the plunger 20 is directed toward the medicinal solution reservoir 10 (the cylinder 11) by the pressing portion 23P Push in further inside (refer to arrow AR4).

[0193] When the plunger 20 is pushed in rapidly, the state in which the contact portion 29 of the plunger 20 is in contact with the protruding portion 15T of the finger grip portion 14D is released. The plunger 20 advances inside the medicinal solution storage part 10. The sealing plug 28 is pressed by the plunger 20 and further enters the inside of the liquid medicine storage portion 10.

[0194] At the start of the second administration of the medicinal solution 60, the contact portion 29 of the plunger 20 may be configured to be frictionally engaged with the inner peripheral surface of the protruding portion 15T. This configuration is obtained by making the protrusion size of the contact portion 29 slightly larger than the inner diameter size of the protrusion 15T.

[0195] According to this configuration, at the start of the second administration, in order to release the frictional engagement between the contact portion 29 and the protruding portion 15T, the pressing portion 23P receives a large pressing force. After the frictional engagement is released by a large pressing force, the plunger 20 can be rapidly pushed into the liquid medicine reservoir 10 in this state. The medicinal solution 60 can also form a good mist in the second administration and can be administered appropriately.

[0196] In this way, the liquid medicine 60 inside the liquid medicine reservoir 10 is sprayed from the spray nozzle 12M (refer to FIG. 1) due to the movement of the sealing plug 28. From the spray nozzle 12M to the other nasal cavity, the medicinal solution 60 is administered in a mist form. The plunger 20 advances until the sealing plug 28 contacts the upper end inside the cylinder 11. The plunger 20 may also be configured to advance until the pressing portion 23P contacts the lower end (the other end 13) of the hanging portion 15 of the finger grip portion 14D.

[0197] As the plunger 20 advances until the sealing plug 28 comes into contact with the upper end of the inside of the cylinder 11, the movement of the plunger 20 with respect to the liquid medicine reservoir 10 is stopped (the state shown in FIG. 33). As the movement of the plunger 20 stops, the second administration is completed, and the nasal cavity administration container 104 shifts to the second administration completion state S26_OThe stroke amount of the plunger 20 with respect to the medicinal solution reservoir 10 defines the second administration amount of the medicinal solution 60. The nasal cavity administration container 104 operates in the above manner, and the administration of the medicinal solution 60 by the nasal cavity administration container 104 is implemented in the above manner.

[0198] (Action, Effect)

[0199] In the nasal cavity administration container 104, as described above, the plunger 20 is provided with a contact portion 25D, and the main body portion 30 (finger grip portion 14D) is provided with a protrusion 15To that is contacted by the plunger 20 The portion 25D is in contact with the protruding portion 15T of the finger grip portion 14D, and the nasal cavity administration container 104 can be easily transferred from the first administration preparation state S21 (refer to FIG. 28) to the first administration start state S22 (refer to FIG. 29) . In addition, as described above, the contact portion 25D can be provided as required.

[0200] In the nasal cavity administration container 104, as described above, the first administration preparation state S21 (refer to FIG. 28), the first administration start state S22 (refer to FIG. 29), and the first administration completion state S23 (Refer to FIG. 30) The plunger movement amount restricting member 40D is always engaged with the main body 30. Only in a state where the pressing portion 23P of the plunger 20 is in contact with the stopper portions 42, 43 of the plunger movement amount restricting member 40D, the state in which the plunger movement amount restricting member 40D is engaged with the main body portion 30 can be released.

[0201] Until the first administration of the medicinal solution 60 is completed, since the plunger movement amount restricting member 40D is not removed from the main body 30, the nasal cavity administration container 104 can reliably administer an appropriate amount of administration. At the same time that the first administration of the medicinal solution 60 is completed, the plunger movement amount restricting member 40D can be easily detached from the main body portion 30 by the hook portion 46J whose engagement has been released. The nasal cavity administration container 104 is highly convenient in preparing for the second administration after the first administration is completed.

[0202] As described above, the nasal cavity medication container 104 is provided with an opening 15Q (first fitting portion) in the main body 30 (specifically, the hanging portion 15 of the finger grip 14D). The plunger movement amount restricting member 40D is provided with a hook portion 46J (second fitting portion). By fitting the hook portion 46J into the opening portion 15Q, the movement of the plunger movement amount restricting member 40D relative to the main body portion 30 is restricted in the same way as in the above-mentioned Embodiments 2 to 4. Since the plunger movement amount restricting member 40D is fixed to the main body 30, the nasal cavity administration container 104 has good operational stability when the plunger 20 is pushed into the medicinal solution storage section 10.

[0203] As mentioned above, each embodiment based on the present invention has been described, and each embodiment disclosed this time is an illustration in all points and not a limitation. In each of the above-mentioned embodiments, although the description is based on the use form of injecting (or inhaling) the liquid medicine 60 into the cylinder 11 in an empty state, it is possible to preliminarily fill the cylinder 11 with the liquid medicine 60. The so-called pre-injection type used in this state can also be applied to the present invention. Therefore, the technical scope of the present invention is indicated by the claims, and it is intended to include all changes within the meaning and scope equivalent to the claims.

[0204] (Explanation of Symbols)

[0205] 10 Chemical reservoir, 11 cylinder, 11H, 13H, 14H, 14J openings, 11R flange (first fitting portion), 12, one end, 12M spray nozzle, 12N nozzle, 13, 23 others One end, 14, 14A, 14B, 14C, 14D finger grips, 14U.15U cutouts, 15 hanging parts, 15C recesses (first fitting parts), 15P convex parts (first fitting parts), 15Q openings (The first fitting part), 15T protrusion, 15V return part, 20 plunger, 21 rib, 23P pressing part, 24 tip part, 25.25D contact part (second contact part), 26 contraction part, 27 contact part (first contact part), 28 sealing plug, 29 contact part, 30 body part, 40, 40A, 40B, 40C, 40D plunger movement restriction member, 40M long groove, 40Y rib, 41 grip Part, 41T end surface, 42, 43 stop part, 42E, 43E clamping part, 46 surrounding part, 46C opening (second fitting part), 46K recess (second fitting part), 46J hook (second Fitting part), 46P convex part (second fitting part), 60 liquid medicine, 62 air, 100, 101, 102, 103, 104 nasal cavity administration container, ARI, AR2, AR2a, AR3, AR4, AR14D, AR20, AR20C, AR40, AR40A, AR40B, AR40C, AR40D, AR41C Arrow, HL·H2 size, LI, L2, L3 interval, Sil, S21, first dosing preparation state, S12, S22 First administration start state, S13, S23 first administration completion state, S14, S24 second administration preparation state, S15, S25 second administration start state, S16, S26 second administration completion state.