Nova Patents
CA2737040C

Polymer conjugates of therapeutic peptides

Abstract

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water- soluble oligomer.

CA2737040C, drawing sheet 1
Sheet 1 of 84

Term

3 yearsleft in the term

Expires 17 September 2029.

  1. Priority
  2. Filed
  3. Granted
  4. Today
  5. Expires

12 claims: 7 independent, 5 dependent

  1. 1
    CA 02737040 2016-08-26 « 425 Claims:1. A conjugate comprising a residue of a carperitide moiety as set forth in SEQ ID NO: 1 covalently attached at the carboxyl group of the aspartic acid to a polyethylene glycol) moiety via an amide linkage.
  2. 4
    The conjugate of any one of claims 1, 2 and 3, wherein the carperitide moiety is recombinantly prepared.
  3. 5
    The conjugate of any one of claims 1, 2 and 3, wherein the carperitide moiety is prepared by chemical synthesis.
  4. 6
    The conjugate of any of claims 1-5, wherein the polyethylene glycol) is terminally capped with an end-capping moiety selected from the group consisting of hydroxy, alkoxy, substituted alkoxy, alkenoxy, substituted alkenoxy, alkynoxy, substituted alkynoxy, aryloxy and substituted aryloxy.
  5. 7
    The conjugate of any of claims 1-5, wherein the poly(ethylene glycol) has a weight-average molecular weight in a range of from about 500 Daltons to about 100,000 Daltons.
  6. 10
    A pharmaceutical composition comprising a conjugate of any one of claims 1-9 and a pharmaceutically acceptable excipient.
  7. 11
    The conjugate of any of claims 1-9 for use in the treatment of heart failure.
Independent claims7