Method for improving the stability of clopidogrel using sulfoalkyl ether cyclodextrin

The present invention relates to clopidogrel-containing compositions, which are present as a free base or a pharmaceutically acceptable salt thereof, in which the amount of clopidogrel is present in the composition, and sulfoalkyl ether cyclodextrin (sae-cd). the compositions may be liquid compositions, suspensions or solids. they may be adapted for oral, perioral or parenteral administration. sae-cd serves to dissolve and stabilize clopidogrel in aqueous medium. the stability of clopidogrel against hydrolytic degradation, thermal degradation and photolytic degradation are improved. the sae-cd shows better results with respect to the cyclodextrin derivatives. the sae-cd containing composition of clopidogrel may be provided in liquid form, solid form or as a reconstitutable powder. both the ready-to-use compositions and the concentrated liquids can be prepared. the liquid composition is optionally available as a clear solution. the compositions herein may be administered periorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and / or therapeutic advantages over the periorally administered tablet compositions and excluding sae-cd.