Systems and methods for spectroscopy of biological tissue

[Subject] The both sides of research of disease diagnosis and disease advance are provided with the probe of useful near-infrared Raman scattering spectroscopy. [Solution means] The system for organization measurement includes the optical fiber probe which has 2 mm or a diameter below it. This small diameter makes it possible to use this system for a coronary artery disease, other Kosuge 腔, or diagnosis of soft tissue with the minimum externally caused injury. A delivery optical fiber is included by the probe connected to the proximal end of a light source. The filter for delivery fibers is included at least for 遠 by the end. This system includes the collection optical fiber (1 or plurality) in the probe which collects the Raman scattering radiation from an organization, and this collection optical fiber is connected to a detector at a proximal end. As for the second fiber, at least 遠 of a collection fiber is arranged at an end. The optical lens system which includes the delivery wave guide tube connected to the delivery fiber, the collection wave guide tube connected to the collection fiber, and a lens is arranged at least for 遠 of a probe at an end. [Selection figure] Fig. 4A