Nova Patents
ATE488581T1

FACTOR VII OR VIIa POLYPEPTIDE VARIANTS

Abstract

The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N-glycosylation site located outside of the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma.

Term

Term ended

Projected expiry passed 29 April 2023, 3.4 years ago.

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35 members in 21 offices

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Priority claims
DocumentOfficeKindDate
37667902United States of AmericaP
0300276DenmarkW

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CA2483478A1CanadaA1
WO03093465A1World Intellectual Property Organization (WIPO)A1
AU2003221469A1AustraliaA1
KR20040106424ARepublic of KoreaA
EP1499719A1European Patent Office (EPO)A1
BR0309576ABrazilA
MXPA04010781AMexicoA
RU2004134726ARussian FederationA
JP2005523723AJapanA
PL373728A1PolandA1
CN1665925AChinaA
ZA200409475BSouth AfricaB
IL164764A0IsraelA0
US2006111282A1United States of AmericaA1
NZ536340ANew ZealandA
US2006270000A1United States of AmericaA1
US2006270001A1United States of AmericaA1
US2006270002A1United States of AmericaA1
US2006276377A1United States of AmericaA1
AU2008261165A1AustraliaA1
US7700733B2United States of AmericaB2
JP2010213706AJapanA
US2010260741A1United States of AmericaA1
EP1499719B1European Patent Office (EPO)B1
AT488581TAustriaT
ATE488581T1This recordAustriaT1
DE60334983D1GermanyD1
CN101942019AChinaA
PT1499719EPortugalE
DK1499719T3DenmarkT3
ES2355713T3SpainT3
SI1499719T1SloveniaT1
KR101121593B1Republic of KoreaB1
IL164764AIsraelA
US9353365B2United States of AmericaB2