Personal containment system with sealed passthrough

A personal containment system includes a generally fluid-tight barrier and a powered air delivery system. The blower is generally isolated from the outer environment and draws purified air from a filter in fluid communication with the blower and generally located outside the containment system. A sealed port between the blower and filter provides a generally fluid tight connection to the barrier and blower during filter replacement. Leakage of contaminants into the system is minimized, and limited to materials that might enter the blower inlet. The blower inlet remains accessible during filter replacement, thereby speeding and simplifying the filter replacement process.