Nova Patents
ATE236992T1

Methods for producing antibody libraries using universal or randomized immunoglobulin light chains

Abstract

The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.

Term

Term ended

Projected expiry passed 1 September 2015, 11.1 years ago.

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109 members in 15 offices

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Priority claims
DocumentOfficeKindDate
30038694United States of AmericaA
9511235United States of AmericaW

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WO9218619A1World Intellectual Property Organization (WIPO)A1
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EP0580737A1European Patent Office (EPO)A1
CA2145757A1CanadaA1
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AU662148B2AustraliaB2
EP0675904A1European Patent Office (EPO)A1
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CA2198899A1CanadaA1
WO9607754A1World Intellectual Property Organization (WIPO)A1
AU3504695AAustraliaA
EP0580737A4European Patent Office (EPO)A4
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NO970221D0NorwayD0
FI970198AFinlandA
FI970198A7FinlandA7
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EP0777497A1European Patent Office (EPO)A1
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US5652138AUnited States of AmericaA
US5658727AUnited States of AmericaA
AU681360B2AustraliaB2
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EP0777497A4European Patent Office (EPO)A4
JPH10504970AJapanA
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US5759817AUnited States of AmericaA
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PT100379BPortugalB
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AT233814TAustriaT
ATE233814T1AustriaT1
EP0779933B1European Patent Office (EPO)B1
DE69332744D1GermanyD1
AT236992TAustriaT
ATE236992T1This recordAustriaT1
DE69530305D1GermanyD1
JP2003204797AJapanA
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US2003187247A1United States of AmericaA1
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ES2196077T3SpainT3
US2004002057A1United States of AmericaA1
DE69332744T2GermanyT2
DE69530305T2GermanyT2
EP0580737B1European Patent Office (EPO)B1
AT269401TAustriaT
ATE269401T1AustriaT1
DE69233367D1GermanyD1
EP1471142A1European Patent Office (EPO)A1
DK0580737T3DenmarkT3
ES2223040T3SpainT3
DE69233367T2GermanyT2
JP3672306B2JapanB2
NO319371B1NorwayB1
JP2005218449AJapanA
US6955900B1United States of AmericaB1
US2006121570A1United States of AmericaA1
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US2006257856A1United States of AmericaA1
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