AT557013T

Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof

Abstract

Benzene derivatives suptituisani Glucopyranosyl general formula Iu wherein R1 is selected from among the meanings hydrogen, fluorine, chlorine, bromine, iodine, C1-4-alkyl, C2-6-alkynyl, C1-4-alkoxy, C2-4-alkenyl-C 1 -C 4-alkoxy, C2-4-alkynyl-C1-4-alkoxy, methyl substituted by 1 to 3 fluorine atoms, ethyl substituted by 1 to 5 fluorine atoms, methoxy substituted by 1 to 3 fluorine atoms, an ethoxy group substituted by 1 to 5 fluorine atoms, a C1-4-alkyl group substituted by a hydroxy or C1-3-alkoxy group, a C2-4-alkoxy group substituted by a hydroxy or C1-3-alkoxy group, C2-6-alkenyl, C3-6-cycloalkyl, C3-6-cycloalkyl-C1-3-alkyl, C3-7-cycloalkoxy, C3-6-cycloalkyl-C1-3-alkoxy, C5-7-cycloalkenyloxy, hydroxy, amino, nitro or cyano, where at C56 -cycloalkyl groups a methylene group may be replaced by O, R 2 denotes hydrogen, fluorine, chlorine, bromine, hydroxy, C1-4-alkyl, C1-4-alkoxy, cyano or nitro, wherein the alkyl or alkoxy group may be mono- or polysubstituted by substituted by fluorine, and R3 is selected from among the meanings tri- (C 1-4 -alkyl) silyl-C1-6-alkyl, C2-6-alkene-1-yl, C2-6-alken-1-yl, amino, C1-3-alkylamino, di- (C1-3-alkyl) amino, pyrrolidin-1-yl, pyrrolidin-2-on-1-yl, piperidin-1-yl, piperidin-2-on-1-yl, morpholin -4-yl, morpholin-3-on-4-yl, piperazin-1-yl, 4- (C1-3-alkyl) -piperazin-1-yl, nitro, C3-7-cycloalkyloxy, C5-7-cycloalkenyloxy, C3-7-cycloalkylsulfanyl, C3-7 cycloalkylsulfinyl, C3-7-cycloalkylsulfonyl, C5-7-cikloalkenilsulfanil, C5-7-cycloalkenylsulfinyl, C5-7-cikloalkenilsulfonil, wherein the above-mentioned alkynyl and alkenyl groups may be mono- or disubstituted fluorine or chlorine, preferably by fluorine, IPRI wherein the above-mentioned alkynyl and alkenyl groups may be mono- or disubstituted by identical or different radicals, L1, whereby the above-mentioned cycloalkyl and cycloalkenyl rings independently of one another may be mono- or disubstituted with fluorine and C1-3-alkyl, wherein IPRI in the above mentioned cycloalkyl and cycloalkenyl rings one or two methylene groups are independently of one another may be replaced by O, S, CO, SO, SO 2 or NR N, preferably from O, CO, S , SO2 or NRN, and most preferably by O or CO, R 4, R 5 independently of one another denote hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, C1-3-alkyl, C1-3-alkoxy, methyl or methoxy which substituted by 1 to 3 fluorine atoms, R N denotes H, C1-4-alkyl, C1-4-alkylcarbonyl or C1-4-alkylsulphonyl, L1 independently of one another are selected from the group consisting of the following: hydroxy, cyano, nitro, C3-7-cycloalkyl, aryl, heteroaryl, C1-4-alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, aminocarbonyl, C1-4-alkylaminocarbonyl, di- (C1-3-alkyl) aminocarbonyl, pyrrolidin-1-ylcarbonyl, piperidin-1 ylcarbonyl, morpholin-4-ylcarbonyl, arylaminocarbonyl, heteroarylamino-carbonyl, C1-4-alkoxycarbonyl, aryl-C1-3-alkoxycarbonyl, heteroaryl-C1-3-alkoxycarbonyl, C1-4-alkyloxy, aryloxy, heteroaryloxy, C1-4 -alkilsulfan

Term

Term ended

Expired 11 March 2025, 1.5 years ago.

  1. Priority
  2. Filed
  3. Granted
  4. Expired
  5. Today

5 priority claims, no other members on record

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Priority claims5

Priority claims
DocumentOfficeKindDate
102004012676GermanyA
102004040168GermanyA
102004061145GermanyA
05002628European Patent Office (EPO)A
2005002618European Patent Office (EPO)W