Biosensor utilizing a resonator having a functionalized surface

Using biosensor to position detecting sample the system and method in for biological molecule, wherein the biosensor with conformed with the resonance, wherein the resonant between controlled by a target biological molecule reaction functionalization surface. The a drawing device, comprising with functionalization of piezoelectric resonance, an embedded-type the functionalize the surface is formed with a target molecule reaction, so the resonator's mass and/or charging, wherein, so the frequency response of the resonance. Exposure the resonance the sample the frequency response and standard colorimetric perform, and an exposure front of line frequency response of the frequency response and memory or comparing the frequency response of resonance.