Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases

The invention claims a chimeric and humanized of mice CDl9 monoclonal antibody. The invention also comprises is that binds human CDl9 antigen in the treatment of drug composition according and immunotherapy composition and preparation method and ADCC and CDC and/or dies, and being used in the treatment of a disease and temperature of oligodendrocytes, for example, but not limit to the B cell malignancy, the treatment and prevention or without dismantling the autoimmune diseases, wherein the treatment and prevention of a transplant receiver the host of of (GVHD) and water solution repel and transplantation, lymph the proliferative disease.