Tissue pathogen inactivation/removal process

A method to inactivate and / or reduce pathogens contained in fabric having a plurality of cavities in living pathogens, which comprises centrifuging the tissue in a centrifuge continuous flow with a solution of pathogen reduction, such that the solution is continuously flowing into the centrifuge and is continuously extracted from the centrifuge containing the tissue, and such that said centrifugation produces a G force on the material which is sufficient to remove contaminants and materials waste tissue and promote penetration of the solution into the tissue so that centrifugation causes the reduction solution pathogens penetrate substantially all cavities in the tissue where they reside pathogens, to leave with it inactive and / or reduce the content of pathogens within said cavities.