Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture

The glucopyranosyl substitution benzonitrile derivative of formula (I) (inside of a formula, R)3は, hydrogen, fluoride, chlorine, bromine, iodine, methyl, ethyl, propyl, Isopropyl, butyl, sec-butyl, isobutyl, tert-butyl, 3-methyl ブタ- 1-イル, cyclo propyl, cyclo butyl, cyclopentyl, Cyclohexyl, difluoromethyl, trifluoromethyl, pentafluoroethyl, 2-hydroxyl ethyl, hydroxymethyl, 3-hydroxypropyl, 2-hydroxy 2-methyl proper 1-イル, 3-hydroxy 3-methyl ブタ- 1-イル, 1-hydroxy 1-methylethyl, 2 and 2, and 2-trifluoro 1-hydroxy 1-methylethyl, 2, 2, and 2-trifluoro 1-hydroxy 1-trifluoro methylethyl, 2-methoxy ethyl, 2-ethoxyethyl, hydroxy 、 methyloxy, Ethyloxy, isopropyloxy, difluoro methyloxy, trifluoro methyloxy, Cyclobutyloxy, cyclopenthyloxy, cyclohexyloxy, (S) -tetrahydro franc 3-yloxy, (R) -tetrahydro franc 3-yloxy, tetrahydro Piran 4-yloxy, 1-アセチル piperidine 4-yloxy, It is 2-methyloxy ethyloxy, methylsulfanyl, methylsulfinyl, methylsulfonyl, ethyl スルフィニル, ethyl sulfo nil, trimethylsilyl, or cyano, or they are those derivatives (being here). One or more hydroxyl machines (C) of a beta-D-glucopyranosyl machine,1-18- アルキル carbonyl (C),1-18- アルキル oxycarbonyl, phenylcarbonyl, and phenyl (C)1-3- It is acylated by the basis chosen from アルキル carbonyl; Or those tautomerism objects, stereoisomeric forms, or those mixtures; Or those salt that may be permitted physiologically is indicated. The compound of the present invention fits the medical treatment of metabolic disorder.