2,4-pyrimidinediamine compounds and uses as anti-proliferative agents

Use of an effective amount of a compound 2,4-pirimidindiamínico according to structural formula (Id) for preparing a medicament for inhibiting proliferation of a cancer cell: Structural formula to (Id) including salts, hydrates, solvates and N-oxides, wherein: Z1 is selected from N and CH; Z2 is selected from NH, O, S and S (O) 2; R16 is selected from hydrogen and methyl; R19 is selected from the group consisting of hydrogen, alkyl (C1-C8), methyl and Rd; R20 is selected from the group consisting of hydrogen, alkyl (C1-C8), methyl and Rd; where each Rd is independently selected from monohydroxy (C1-C8) and dihydroxy (C1C8); R24 is selected from hydrogen and methyl; R41 is selected from alkyl (C1-C8), methyl; (C1-C8), methoxy, halo, chloro, trifluoromethyl and -CH2OH; R42 is selected from hydrogen, (C1-C8), methyl, hydroxy, (C1-C8), methoxy, halo, chloro, trifluoromethyl, trifluoromethoxy, -OCH2C (O) NHRa, and ** ** ** Formula Formula ** and R43 is selected from hydrogen, (C1-C8), methyl, hydroxy, (C1-C8), methoxy, halo, chloro, trifluoromethyl, trifluoromethoxy, -OCH2C (O) NHRa, -OCH2C (O) ORa ** Formula Formula ** and ** ** where each R12 is independently selected from the group consisting of alkyl (C1-C8) alkyl, aryl, - ORa, -NRcRc, -C (O) Ra, -C (O) ORa and -C (O) NRcRc; each R is independently selected from the group consisting of hydrogen, alkyl (C1-C8), (C3-C8), cycloalkyl (C3-C8) alkyl (C1-C4) alkyl, phenyl and benzyl; and each Rc is independently selected from the group consisting of hydrogen, (C1-C8) and cycloalkyl (C3-C8), or alternatively, may take two Rc together with the nitrogen atom to which they are attached to form a saturated ring 5-7 membered optionally includes an additional 1-2 heteroaromatic groups selected from O, NRa, NRa-C (O) Ra, NRa-C (O) ORa and NR-C (O) NR provided that (i) when R42 ** ** Formula is or then R43 ** ** Formula not be ** ** Formula or and (ii) when R43 is ** ** · Formula then R42 or will not be ** ** Formula