Non-cytotoxic protein conjugates

[Subject] Provide a change non-cytotoxic joint object in which joint compatibility is shown to a target cell which feels a pain.<br />[Means for Solution] A non-cytotoxic protein bond object for prevention of Ekisosai ptosis fusion in an infringement acceptance feeling centrality cell or reduction is indicated, and it is the joint object, (i) Include predetermined, targeting partial (TM) ; (ii) predetermined non-cytotoxic protease or its fragmentation;, and a (iii) predetermined translocation domain.<br />[Chosen drawing] Nothing