Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5

i) the ヘテロア reel portion containing N which adjoined the joint of the ヘテロア reel, and ii -- another ヘテロア reel or an arylamine ring (at least 1 side of the rings of these) it is further replaced with another ring -- てい -- the tetrazole compound replaced by direct or bridge construction, For example, soul, such as integration dysfunction syndorome, insecurity, depression, panic, and bipolar disorder, and medical treatment of mood disorders, And in sharp pain, Parkinson's disease, cognitive impairment, 癲癇, a circadian rhythm obstacle, drug addiction, drug abuse, medicine withdrawal symptoms, overweight, and the medical treatment of other illnesses, it is mGluR5 useful modulator.