Mutant il-10

Although the anti-inflammatory characteristic of wild nature type IL*10 for which it asks remedially is held, hematogenous cell regulation activity and cell-growth activity indicate the IL*10 arrangement change object which is not held. It uses in the method of dealing with the disease about an inflammatory response which includes the sharp pain and other neurological obstacles of neuropathy nature for mutant IL*10 polypeptide of the present invention. Protein for the present invention to deal with the neuropathy nature sharp pain, the neurological obstacle, and other inflammatory obstacles of using varied type IL*10, The protein, composite, and method which are replaced from amino acid with an another 残 machine which are a composite and a method and exists in the position corresponding to the amino acid position 129 of the arrangement numbers 2 and 3 here are offered. With a desirable enforcement form, amino acid phenyl アラン which usually exists in the amino acid position 129 of IL*10 of Latt and humans is replaced by amino acid serine. This variation is named "F129S. "