Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors
Abstract
1. Compounds of formula (I)! ! where X represents C (R8R9), NR10, O, S, S (O), S (O2); ! R1 is phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, hydroxy, lower alkyl, hydroxy-lower-alkyl, fluoro-lower-alkyl, lower-alkoxy and CN; ! R2 is hydrogen or lower alkyl; ! R3 and R4 independently of one another are hydrogen, halogen, lower alkyl or lower alkoxy, or R3 and R4 together represent = O, forming a carbonyl group together with the carbon atom to which they are attached; ! R5 and R6 each independently are hydrogen, halogen, lower alkyl or lower alkoxy, or R5 and R6 together represent = O, forming a carbonyl group together with the carbon atom to which they are attached; ! R7 represents oxadiazolyl or triazolyl, wherein oxadiazolyl or triazolyl substituted with R11 and optionally substituted with R12; ! R8 and R9 independently of one another are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or! R8 and R9 are joined together and -R8-R9- is - (CH2) 2-7- to form a ring together with the carbon atom to which they are attached; ! R10 is hydrogen, lower alkyl, lower alkyl-carbonyl or lower-alkyl-sulfonyl; ! R11 is aryl or heteroaryl selected from the group consisting of pyridinyl, pyrazinyl, pyrimidinyl, pyridinyl-2-one, oxadiazolyl, indazolyl, 1,3-dihydro-benzoimidazol-2-one, 1,3-dihydro-indol-2-one, benztriazolyl, imidazopyridinyl , triazolpiridinil, tetrazolpiridinil, benzimidazolyl, 2-oxo-2,3-dihydro-1H-indol-5-yl, pyrimidin-4-one, furanyl, thiadiazolyl, pyrazolyl, isoxazolyl, pyrimidine-2,4-dione, 3-benzoxazin -one, 1,
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
30 members in 19 offices
Priority claims2
| Document | Office | Kind | Date |
|---|---|---|---|
| 05111560 | European Patent Office (EPO) | A | |
| 2006068745 | European Patent Office (EPO) | W |
Members30
| Document | Office | Kind | |
|---|---|---|---|
| AU2006319247A1 | Australia | A1 | |
| CA2630460A1 | Canada | A1 | |
| US2007129544A1 | United States of America | A1 | |
| WO2007063012A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AR056821A1 | Argentina | A1 | |
| TW200804357A | Taiwan Province of China | A | |
| AU2006319247A8 | Australia | A8 | |
| KR20080072097A | Republic of Korea | A | |
| NO20082388L | Norway | L | |
| EP1959951A1 | European Patent Office (EPO) | A1 | |
| CN101321525A | China | A | |
| ZA200804393B | South Africa | B | |
| JP2009517438A | Japan | A | |
| EP1959951B1 | European Patent Office (EPO) | B1 | |
| RU2008126398A | Russian Federation | A | |
| US7645776B2 | United States of America | B2 | |
| AT452635TThis record | Austria | T | |
| ATE452635T1 | Austria | T1 | |
| DE602006011363D1 | Germany | D1 | |
| PT1959951E | Portugal | E | |
| AU2006319247B2 | Australia | B2 | |
| ES2335698T3 | Spain | T3 | |
| PL1959951T3 | Poland | T3 | |
| RU2396269C2 | Russian Federation | C2 | |
| BRPI0619086A2 | Brazil | A2 | |
| JP4855478B2 | Japan | B2 | |
| TWI358409B | Taiwan Province of China | B | |
| KR101135310B1 | Republic of Korea | B1 | |
| CA2630460C | Canada | C | |
| CN101321525B | China | B |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Publication of translation of european patent specificationUEP | UEP |
Numbers
- Application
- 6819660
Titles2
- German
- HETEROARYL-SUBSTITUIERTE PIPERIDIN-DERIVATE ALS L-CPT1-HEMMER
- English
- Heteroaryl-substituted steroid derivatives as L-CPT1 inhibitors
Classification
- CPC, 16
- C07D413/04
- A61P1/16
- C07D401/04
- A61P3/04
- C07D401/14
- A61P3/06
- C07D413/14
- A61P3/08
- C07D417/04
- A61P3/10
- C07D417/14
- A61P9/04
- A61P9/10
- A61P9/12
- A61P13/12
- A61P43/00
- IPC, 6
- A61K31 4192
- A61K31 4196
- A61K31 4245
- A61P3 06
- A61P3 08
- C07D413 04