AT452635T

Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors

Abstract

1. Compounds of formula (I)! ! where X represents C (R8R9), NR10, O, S, S (O), S (O2); ! R1 is phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, hydroxy, lower alkyl, hydroxy-lower-alkyl, fluoro-lower-alkyl, lower-alkoxy and CN; ! R2 is hydrogen or lower alkyl; ! R3 and R4 independently of one another are hydrogen, halogen, lower alkyl or lower alkoxy, or R3 and R4 together represent = O, forming a carbonyl group together with the carbon atom to which they are attached; ! R5 and R6 each independently are hydrogen, halogen, lower alkyl or lower alkoxy, or R5 and R6 together represent = O, forming a carbonyl group together with the carbon atom to which they are attached; ! R7 represents oxadiazolyl or triazolyl, wherein oxadiazolyl or triazolyl substituted with R11 and optionally substituted with R12; ! R8 and R9 independently of one another are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or! R8 and R9 are joined together and -R8-R9- is - (CH2) 2-7- to form a ring together with the carbon atom to which they are attached; ! R10 is hydrogen, lower alkyl, lower alkyl-carbonyl or lower-alkyl-sulfonyl; ! R11 is aryl or heteroaryl selected from the group consisting of pyridinyl, pyrazinyl, pyrimidinyl, pyridinyl-2-one, oxadiazolyl, indazolyl, 1,3-dihydro-benzoimidazol-2-one, 1,3-dihydro-indol-2-one, benztriazolyl, imidazopyridinyl , triazolpiridinil, tetrazolpiridinil, benzimidazolyl, 2-oxo-2,3-dihydro-1H-indol-5-yl, pyrimidin-4-one, furanyl, thiadiazolyl, pyrazolyl, isoxazolyl, pyrimidine-2,4-dione, 3-benzoxazin -one, 1,

Term

No projected expiry on record.

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Priority claims
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05111560European Patent Office (EPO)A
2006068745European Patent Office (EPO)W

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