Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

A compound having the formula ** (See formula) ** forms N-oxide, pharmaceutically acceptable salts and isomeric addition thereof, wherein X represents C or N stereochemically forms; Y represents C or N; L represents a methyl or a direct bond; Z1 represents a direct bond, C1-2 alkyl or a radical of formula -CH2-CH = (a) or -CH = (b); Z2 represents a direct bond, C1-2 alkyl or a radical of formula -CH2-CH = (a) or -CH = (b); R1 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4 alkoxy, -O- (C = O) -C 1-4 alkyl, hydroxycarbonyl, NR3R4 or C1-4alkyl wherein said C1-4alkyl or - O- (C = O) -C 1-4 alkyl are optionally substituted with one or more substituents selected from halo, hydroxycarbonyl, phenyl, C1-4 alkyloxy or NR5R6, or R1 represents C1-4 alkyloxy optionally substituted with one or more substituents selected halo, hydroxycarbonyl, phenyl, C1-4 alkyloxy or NR7R8; R2 represents hydrogen, halo, C1-4 alkyl or oxy C1-4 alkyl; R3 and R4 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl; R5 and R6 represent each independently hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl; R7 and R8 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl; A represents phenyl or a monocyclic heterocycle selected from the group consisting of thiophenyl, furanyl, oxazolyl, thiazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and piperazinyl.