Bioactive agent release coating and controlled humidity method

One copy or the coating composite of the form of a multi-part system used for coating the device surface in order to control and/or improve the capability to emit a biologically active substance to a water system, and the method of applying such a composite under the controlled humidity conditions. The coating composite is suitable for especially using it by the medicine device which receives big crookedness and/or expansion in process of the delivery and/or use, for example as a stent and a catheter. A composite The 1st polymer component, such as the poly アルキル (meta) アクリ rate, a ポリア reel (meta) アクリ rate, the poly aralkyl (meta) アクリ rate, or a ポリアリールオキシアルキル (meta) アクリ rate, A biologically active substance is included in combination with the 2nd polymer component, such as poly (ethylene *co* vinyl acetate).