Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists

Type (I) of smoke alkaline acetyl choline receptor excited agent, which D,Ar1,E, and Ar2 as manual in the by defined, its on map isomers, pharmacy Shang can accept of salt, preparation method, contains the compounds of drug combination property, and using the smoke alkaline acetyl choline receptor excited agent treatment or prevention psychiatric, and intelligence injury illness, and Alzheimer's 's disease, and learning capacity insufficient, and cognitive insufficient, and attention insufficient, and memory missing, and Louis small body dementia, and attention insufficient caused of function hyperthyroidism, and anxiety, and schizophrenia , Mania or manic depressive disorder, Parkinson's disease, Huntington's disease and Tourette Syndrome, there is loss of cholinergic synaptic neurodegenerative illness, jet lag, nicotine addiction, smoking cessation, pain, ulcerative colitis or irritable bowel disease.