Iap binding compounds

Compound of formula I: ** ** see formula wherein R1 is methyl, ethyl, n-propyl, isopropyl or ethenyl; R1a is H or methyl; X is -O-, -S-, -CH 2 or -NH-, and J is -CH- or -N-, provided that when J is -N-, X is -CH 2 or -NH-; Y is H, methyl, ethyl, n-propyl or isopropyl; R 2 is R ** ** see formula 2a is cycloalkyl, cycloalkylalkyl, alpha-naphthylmethyl, beta-naphthylmethyl or a benzyl substituted with one or more halogen, aryl, carboxyl, alkoxycarbonyl or aroyl, or combinations thereof: R 2b is H or alkyl; M is Ar ** ** see formula is formula ** ** see R3, R4, R5, R6, R7, R8 and R9 are each independently H, methyl, ethyl, n-propyl, isopropyl, halogen, cyano, - (CH2) pC (= O) OH, - (CHZ) pC (= O) O-alkyl, - (CHZ) pC (= O) NH2; 3; n and p are each independently the integer 0, 1, 2 or 3 and the sum of (n + p) is the integer 2 or provided that at least one of R 3, R 4 and R 5 or at least two of R 6, R 7, R 8 and R 9 are each independently H, methyl, ethyl, n-propyl, isopropyl, halogen or cyano; provided that when one or more of R 3 and R 5 is isopropyl, R 4 is other than isopropyl; provided that when R 4 is isopropyl, R 3 and R 5 are each independently other than isopropyl; provided that when R8 is isopropyl, R9 is other than isopropyl; and provided that when R 1a is H, X is -NH-, J is -CH-, Y is H, methyl or isopropyl, and R 2 is: ** ** see formula R 1 is ethenyl; or a pharmaceutically acceptable salt thereof.