Pharmaceuticals for simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists

(57) Summary book invention enhances alternatively the analgesic action of both the action nature opioid active substance of morphine or others by which clinical application is carried out, Simultaneously the side effects of the physical dependency seen at the time of continuous use of both the action nature opioid active substance, tolerance, and others about the method for reducing this method, It includes prescribing for the patient both both the action nature opioid active substance that activates the control nature of the infringement acceptance (痛覚) course of a nervous system, and an excitability opioid receptor regulation function, and the opioid receptor rivalry substance which carries out inactivation of the excitability opioid receptor regulation side effects alternatively. Moreover, the present invention relates to the method of using only an excitability opioid receptor rivalry substance, in order to act as Brock of the excitability side effects that it does not ask for endogenous both the action nature opioid active substance that increases notably in the case of chronic sharp pain. Whether the present invention uses together with the methadone of a low given dose in order to control dependence revelation or, without furthermore, using together, It is related with the composite containing the excitability opioid receptor rivalry substance of the present invention, and both the action nature opioid active substance, concerning the prolonged medical treatment method of the addict of オピエート, cocaine, or alcohol using the above-mentioned excitability opioid receptor rivalry substance.