Immobilized bioactive hydrogel matrices as surface coatings

A coated medical device comprising: a medical device having a surface; and a layer of bioactive hydrogel matrix covering said surface of said medical device and is immobilized thereon, said matrix comprising a polyglycan component and a polypeptide component, wherein at least one of said polyglycan component and said polypeptide component is covalently bonded to said surface of said doctor or trapped device within said surface of said medical device, in which the bond is covalent produced by reacting a polypeptide reactive group led by at least one of said polyglycan component and that component with a group reagent carried by said surface of said medical device, and wherein entrapment occurs by deswelling a surface swollen polymer of said medical device through the exchange of the liquid phase with a liquid comprising at least one of said polyglycan component and said polypeptide component.