Fused ring azadecalin glucocorticoid receptor modulators
Abstract
A compound having the formula: R 1. (Omitted) wherein L 1 and L 2 are independently selected from a bond, O, S, S (O), S (O2), C (O), C (O) O, C (O) NH members , substituted or unsubstituted alkylene and substituted or unsubstituted heteroalkylene; the dashed line b is optionally a bond; ring A is a member selected from heterocycloalkyl substituted 5 to 6 members or unsubstituted heteroaryl and substituted or unsubstituted; R 1 is a member selected from hydrogen, substituted or unsubstituted, substituted or unsubstituted heteroalkyl, substituted cycloalkyl or unsubstituted or substituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, OR 1A, NR 1C R 1D, -C (O) NR 1C R 1D, -C (O) oR 1A, wherein R 1A is a member selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, heterocycloalkyl substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted; R 1C and R 1D are independently selected from substituted or or or or unsubstituted alkyl, substituted heteroalkyl, unsubstituted substituted unsubstituted cycloalkyl, substituted heterocycloalkyl unsubstituted aryl, substituted or unsubstituted members and substituted or unsubstituted heteroaryl, wherein R 1C and R 1D are optionally joined to form a substituted or unsubstituted with the nitrogen to which they are attached, wherein said ring optionally comprises an additional ring nitrogen ring, and R 2 is a member selected from substituted or unsubstituted alkyl, substituted heteroalkyl or unsubstituted cycloalkyl, substituted or unsubstituted, substituted heterocycloalkyl or unsubstituted aryl substituted or unsubstituted, substituted or unsubstituted heteroaryl, S (O2) R 2A, S (O2) NR 2B R 2C and = NOR 2D, wherein R 2A , R 2B, R 2C, and 2D R are independently selected from substituted or or or or unsubstituted alkyl, substituted heteroalkyl, unsubstituted substituted unsubstituted cycloalkyl, substituted heterocycloalkyl unsubstituted aryl, substituted or unsubstituted members and substituted or unsubstituted heteroaryl .
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
30 members in 17 offices
Priority claims1
| Document | Office | Kind | Date |
|---|---|---|---|
| 55183604 | United States of America | P |
Members30
| Document | Office | Kind | |
|---|---|---|---|
| AU2005222421A1 | Australia | A1 | |
| CA2558899A1 | Canada | A1 | |
| WO2005087769A1 | World Intellectual Property Organization (WIPO) | A1 | |
| EP1735308A1 | European Patent Office (EPO) | A1 | |
| IL177982A0 | Israel | A0 | |
| KR20070029684A | Republic of Korea | A | |
| CN101027301A | China | A | |
| JP2007528417A | Japan | A | |
| US2007281928A1 | United States of America | A1 | |
| HK1104813A1 | Hong Kong, China | A1 | |
| EP1735308B1 | European Patent Office (EPO) | B1 | |
| AT407934TThis record | Austria | T | |
| ATE407934T1 | Austria | T1 | |
| DE602005009687D1 | Germany | D1 | |
| PT1735308E | Portugal | E | |
| DK1735308T3 | Denmark | T3 | |
| ZA200608306B | South Africa | B | |
| ES2313317T3 | Spain | T3 | |
| NZ550362A | New Zealand | A | |
| AU2005222421B2 | Australia | B2 | |
| US7928237B2 | United States of America | B2 | |
| CN101027301B | China | B | |
| US2011166110A1 | United States of America | A1 | |
| JP4931794B2 | Japan | B2 | |
| US2012225856A1 | United States of America | A1 | |
| KR101185281B1 | Republic of Korea | B1 | |
| IL177982A | Israel | A | |
| CA2558899C | Canada | C | |
| US8557839B2 | United States of America | B2 | |
| US2014179671A1 | United States of America | A1 |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Publication of translation of european patent specificationUEP | UEP |
Numbers
- Application
- 5725295
Titles2
- German
- AZADECALINVERBINDUNGEN MIT KONDENSIERTEM RING ALS GLUCOCORTICOIDREZEPTORMODULATOREN
- English
- AZADECALIN COMPOUNDS WITH CONDENSED RING AS GLUCOCORTICOID RECEPTOR MODULATORS
Classification
- CPC, 30
- C07D471/04
- A61P3/04
- A61P3/10
- A61P3/12
- A61P5/42
- A61P5/46
- A61P9/00
- A61P9/04
- A61P9/06
- A61P9/12
- A61P13/12
- A61P17/02
- A61P19/00
- A61P19/02
- A61P25/00
- A61P25/06
- A61P25/16
- A61P25/22
- A61P25/24
- A61P25/28
- A61P25/36
- A61P27/06
- A61P27/16
- A61P29/00
- A61P31/00
- A61P31/12
- A61P37/00
- A61P37/08
- A61P43/00
- C07D498/04
- IPC, 4
- C07D471 04
- A61K31 437
- A61P25 24
- C07D498 04