Dipeptidyl peptidase inhibitors

A compound comprising: Gdem is CR 4; R 2 is hydrogen or selected from the group consisting of (C1-10) alkyl, (C3-12) cycloalkyl, (C3-12) cycloalkyl (C1-5) alkyl, hetero ( C 3-12) cycloalkyl (C 1-5) alkyl, hetero (C3-12) cycloalkyl, aryl (C 1-10) alkyl, heteroaryl (C1-5) alkyl, (C9-12) bicycloalkyl, hetero (C4-12 ) bicycloalkyl, hetero (C4-12) bicycloalkyl (C1-5) alkyl, carbonyl (C1-3) alkyl, thiocarbonyl (C1-3) alkyl, sulfonyl (C 1-3) alkyl, sulfinyl (Cl-3) alkyl, imino (C 1-3) alkyl, amino, aryl, heteroaryl, hydroxy, alkoxy, aryloxy, heteroaryloxy, carbonyl group, imino group, sulfonyl group and sulfinyl group, each substituted or unsubstituted; R 3 contains formulugde are each R 10 and R 11 are independently selected from the group consisting of hydrogen, perhalo (C1-10) alkyl, amino, (C1-10) alkyl, (C3-12) cycloalkyl, hetero (C3-12) cycloalkyl, aryl (C1-10) alkyl, heteroaryl (C1- 5) alkyl, (C9-12) bicycloalkyl, hetero (C4-12), carbonyl (C1-3) alkyl, thiocarbonyl (C1-3) alkyl, aryl, heteroaryl, hydroxy, alkoxy, aryloxy, heteroaryloxy, carbonyl group, sulfonyl group and sulfinyl group, each of which is substituted or unsubstituted, or R 10 and R 11 are taken together to form a 4, 5, 6 or 7 membered ring, each substituted or unsubstituted; R 4 is hydrogen or is selected from the group consisting of halo. perhalo (C1-10) alkyl, amino, cyano, thio. (C 1-10) alkyl. cycloalkyl. heterocycloalkyl. arylalkyl, heteroarylalkyl, aryl, heteroaryl. carbonyl (C 1-3) alkyl. thiocarbonyl (C 1-3) alkyl, sulfonyl (C 1-3) alkyl. sulfinyl (C 1-3) alkyl. imino (C 1-3) alkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, carbonyl group, imino group, sulfonyl group and sulfinyl group, each substituted or unsubstituted; ILX taken together is selected from the group consisting of - (CH2) - (2-cyano) phenyl; - (CH2) - (3-cyano) phenyl; - (CH2) - (2-hydroxy) phenyl; - (CH2) - (3-hydroxy) phenyl; - (CH2) - (2-alkenyl) phenyl; - (CH2) - (3-alkenyl) phenyl; - (CH2) - (2-alkynyl) phenyl; - (CH2) - (3-alkynyl) phenyl; - (CH2) - (2-methoxy) phenyl; - (CH2) - (3-methoxy) phenyl; - (CH2) - (2-nitro) phenyl; - (CH2) - (3-nitro) phenyl; - (CH2) - (2-carboxy) phenyl; - (CH2) - (3-carboxy) phenyl; - (CH2) - (2-carboxamido) phenyl; - (CH2) - (3-carboxamido) phenyl; - (CH2) - (2-sulfonamido) phenyl; - (CH2) - (3-sulfonamido) phenyl; - (CH2) - (2-tetrazolyl) phenyl; - (CH2) - (3-tetrazolyl) phenyl; - (CH2) - (2-aminomethyl) phenyl; - (CH2) - (3-aminomethyl) phenyl; - (CH2) - (2-hydroxymethyl) phenyl; - (CH2) - (3-hydroxymethyl) phenyl; - (CH2) - (2-phenyl) phenyl; - (CH2) - (3-phenyl) phenyl; - (CH2) - (2-halo) phenyl; - (CH2) - (3-halo) phenyl; - (CH2) - (2-CONH2) phenyl; - (CH2) - (3-CONH2) phenyl; - (CH2) - (2-CONH (C1-7) alkyl) phenyl; - (CH2) - (3-CONH (C1-7) alkyl) phenyl; - (CH2) - (2-C02 (C 1-7) alkyl) phenyl; - (CH2) - (3-CO2 (C1-7) alkyl) phenyl; - (CH2) - (2-NH2) phenyl; - (CH2) - (3-NH2) phenyl; - (CH2) - (2- (C3-7) alkyl) phenyl; - (CH2) - (3- (C3-7) alkyl) phenyl; - (CH2) - (2- (C3-7) cycloalkyl) phenyl; - (CH2) - (3- (C3-7) cycloalkyl) phenyl; - (CH2) - (2-aryl) phenyl; - (CH2) - (3-aryl) phenyl; - (CH2) - (2-heteroaryl) phenyl; - (CH2) - (3-heteroaryl) phenyl; - (CH2) -2-bromo-5-fluoro-