Neovascular-targeted immunoconjugates

(57) A summary and subject The immunity complex for treating cancer, rheumatoid arthritis, the macular degeneration of an exudative form, and the disease relevant to a blood vessel rebirth like an atherosclerotic cardiovascular disease is offered. Solution means The immunity complex concerned typically, When Fc domain of human IgG1 immunoglobulin including a hinge or a patient is medicated, it consists of other effector domains (one or more than it) which can induce a cytolytic property immune response or a cell damage action to a target cell. The by which, as for the effector domain, an alanine or serine *344 were replaced for ricin *341 by the alanine -- blood coagulation is not made to start although it combines with a tissue factor by the high affinity and singularity like a VII factor -- the -- it is compounded with the target domain containing a VII factor mutant.