Methods for purification of cells based on product secretion

The present invention offers the method for refining one or more cells based on the level of one or more products secreted by the cell. Two or more cells in which the method was fixed by the proximity of (a) capture matrix, It is the process of detecting the characteristic of two or more lights oriented from the process; (b) ; [process / which is illuminated into the group of the cell] (c) frame on which the factor alternatively combined with a product is contacted, process; (d) (i) which the characteristic of the 1st light identifies all the cells substantially [the group], and identifies the product in which the characteristic of the 2nd light was localized by the capture matrix -- being related with the characteristic of the 1st detected light -- the group -- substantial -- all the cells --and (ii) -- the process of spotting one or more selected cells about the characteristic of the 2nd detected light, and (e) non selection cell are irradiated, and the process at which one or more selected cells which has a desired product secretion profile are refined is included.