Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver
Abstract
Use of at least one antagonist adenosine A2A receptor for the preparation of a medicine for treating or preventing hepatic fibrosis, cirrhosis and / or fatty liver with complications, wherein the antagonist adenosine A2A receptor is selected from from the group consisting of 2-fenilaminoadenosina, 2-p-2-carboxietilfenilamino- 5 '' - N-ethylcarboxamido-adenosine, 5-N-ethylcarboxamido-adenosine, 5 '' - N-ciclopropiladenosina, 5''N-metilcarboxamidoadenosina, 8- (3-chlorostyryl) caffeine, PD-1259444, 1,3-dipropyl-phenylxanthine and 4- {2- [7-amino-2- (2-furyl) [1,2,4] -triazolo [2, 3-a] - [1,3,5] triazin-5-ylamino] ethyl} phenol (ZM 241385), 8-estirílicos derivatives of 1,3-7- alkylxanthines of the following formula: (See formula) in R1 and R3 are methyl, ethyl, propyl or allyl; R7 is H, methyl, or C1-C8 alkyl; R is hydrogen; and compounds of the following formula: wherein Y is m-Br or p-SO3H (See formulas)
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
18 members in 11 offices
Priority claims1
| Document | Office | Kind | Date |
|---|---|---|---|
| 18154600 | United States of America | P |
Members18
| Document | Office | Kind | |
|---|---|---|---|
| CA2398908A1 | Canada | A1 | |
| WO0158241A2 | World Intellectual Property Organization (WIPO) | A2 | |
| AU3812401A | Australia | A | |
| US2002002145A1 | United States of America | A1 | |
| WO0158241A9 | World Intellectual Property Organization (WIPO) | A9 | |
| EP1272897A2 | European Patent Office (EPO) | A2 | |
| US6555545B2 | United States of America | B2 | |
| JP2004502640A | Japan | A | |
| AU2001238124B2 | Australia | B2 | |
| AU2006203699A1 | Australia | A1 | |
| EP1272897B1 | European Patent Office (EPO) | B1 | |
| AT394104TThis record | Austria | T | |
| DE60133887D1 | Germany | D1 | |
| PT1272897E | Portugal | E | |
| DK1272897T3 | Denmark | T3 | |
| ES2307593T3 | Spain | T3 | |
| CA2398908C | Canada | C | |
| AU2006203699B2 | Australia | B2 |
2 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Ceased due to non-payment of the annual feeCeasedREN | REN | |
| Publication of translation of european patent specificationUEP | UEP |
Numbers
- Application
- 1910529
Titles2
- German
- ADENOSIN A2A REZEPTOR-ANTAGONISTEN ZUR BEHANDLUNG UND VORBEUGUNG VON LEBERFIBROSE, ZIRRHOSE UND FETTLEBER
- English
- ADENOSINE A2A RECEPTOR ANTAGONISTS FOR THE TREATMENT AND PREVENTION OF LIVER FIBROSIS, CIRRHOSIS AND FATTENERS
Classification
- CPC, 8
- A61K31/7076
- A61K31/522
- A61K31/53
- A61P1/16
- A61P31/12
- A61P37/00
- A61P39/02
- A61P43/00
- IPC, 15
- A61K31 519
- A61K31 52
- A61K31 522
- A61K31 53
- A61K31 549
- A61K31 7076
- A61K45 00
- A61P1 16
- A61P31 12
- A61P37 00
- A61P39 02
- A61P43 00
- C07D473 10
- C07D487 04
- C07D487 14