AT394104T

Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver

Abstract

Use of at least one antagonist adenosine A2A receptor for the preparation of a medicine for treating or preventing hepatic fibrosis, cirrhosis and / or fatty liver with complications, wherein the antagonist adenosine A2A receptor is selected from from the group consisting of 2-fenilaminoadenosina, 2-p-2-carboxietilfenilamino- 5 '' - N-ethylcarboxamido-adenosine, 5-N-ethylcarboxamido-adenosine, 5 '' - N-ciclopropiladenosina, 5''N-metilcarboxamidoadenosina, 8- (3-chlorostyryl) caffeine, PD-1259444, 1,3-dipropyl-phenylxanthine and 4- {2- [7-amino-2- (2-furyl) [1,2,4] -triazolo [2, 3-a] - [1,3,5] triazin-5-ylamino] ethyl} phenol (ZM 241385), 8-estirílicos derivatives of 1,3-7- alkylxanthines of the following formula: (See formula) in R1 and R3 are methyl, ethyl, propyl or allyl; R7 is H, methyl, or C1-C8 alkyl; R is hydrogen; and compounds of the following formula: wherein Y is m-Br or p-SO3H (See formulas)

Term

No projected expiry on record.

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18 members in 11 offices

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Priority claims
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18154600United States of AmericaP

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CA2398908A1CanadaA1
WO0158241A2World Intellectual Property Organization (WIPO)A2
AU3812401AAustraliaA
US2002002145A1United States of AmericaA1
WO0158241A9World Intellectual Property Organization (WIPO)A9
EP1272897A2European Patent Office (EPO)A2
US6555545B2United States of AmericaB2
JP2004502640AJapanA
AU2001238124B2AustraliaB2
AU2006203699A1AustraliaA1
EP1272897B1European Patent Office (EPO)B1
AT394104TThis recordAustriaT
DE60133887D1GermanyD1
PT1272897EPortugalE
DK1272897T3DenmarkT3
ES2307593T3SpainT3
CA2398908CCanadaC
AU2006203699B2AustraliaB2