2-amino-5-benzoylthiazole npy antagonists
Abstract
1. Compounds of formula IgdeRoznachaet amino, aryl or heteroaryl, is hydrogen or alkyl, is hydrogen, alkyl or halogen; R-alkyl or halogen, is hydrogen, alkyl or halogen, a is 0 or 1, ab is 0, 1 or 2 and their pharmaceutically acceptable salts and esters efiry.2. Compounds according to claim 1, wherein R vodorod.3. Compounds according to claim 1, wherein R vodorod.4. Compounds according to claim 1, wherein R alkil.5. Compounds according to claim 4, wherein R metil.6. Compounds according to claim 1, wherein R vodorod.7. Compounds according to claim 1, wherein b is equal to 0.8. Compounds according to claim 1, wherein a is 0.9. Compounds according to claim 1, wherein a is 1.10. Compounds according to claim 1, wherein R monoalkylamino, dialkylamino, phenyl, thiophenyl or pyrrolidinyl, wherein phenyl, thiophenyl and pyrrolidinyl are optionally substituted with one to three substituents independently selected from the group consisting of alkyl, halogen, alkoxy, trifluoromethoxy, nitro and triftormetil.11. Compounds according to claim 10, wherein R thiophen-3-yl, 3-fluorophenyl, 4-fluorophenyl, 2-methylphenyl, 2-methoxy-5-methylphenyl, dimethylamino, thiophene-2-yl, 5-fluoro-2-methylphenyl, 2,4-difluorophenyl, 5-chloro-2-methoxyphenyl, 2-fluorophenyl, 3-fluorophenyl, 2-chloro-5-trifluoromethylphenyl, 3-nitrophenyl, 4-nitrophenyl or 4-metoksifenil.12. Compounds according to claim 1, selected from the group consisting of {4- [5- (2-methylbenzoyl) thiazol-2-ylamino] -phenyl} -amide thiophene-2-sulfonic acid {4- [5- (2-methylbenzoyl) -thiazol -2-ylamino] -phenyl} -amide thiophene-3-sulfonic acid, 5- {4- [5- (2-methylbenzoyl) thiazol-2-ylamino] -phenyl} -amide chlorothiophene-2-sulfonic acid, 2-fluoro-N- {4- [5- (2-methylbenzoyl) thiazol-2-ylamino] -phenyl} -benzenesulfonamide, 3-fluoro-N- {4- [5- (2-methylbenzoyl) thiazol-2-ylamino] -phenyl} -benzenesulfonamide,
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
18 members in 14 offices
Priority claims1
| Document | Office | Kind | Date |
|---|---|---|---|
| 03017634 | European Patent Office (EPO) | A |
Members18
| Document | Office | Kind | |
|---|---|---|---|
| AU2004263311A1 | Australia | A1 | |
| CA2533463A1 | Canada | A1 | |
| US2005038089A1 | United States of America | A1 | |
| WO2005014592A1 | World Intellectual Property Organization (WIPO) | A1 | |
| KR20060037435A | Republic of Korea | A | |
| MXPA06001570A | Mexico | A | |
| EP1658288A1 | European Patent Office (EPO) | A1 | |
| BRPI0413500A | Brazil | A | |
| CN1852907A | China | A | |
| JP2007501823A | Japan | A | |
| US7250431B2 | United States of America | B2 | |
| RU2006107444A | Russian Federation | A | |
| EP1658288B1 | European Patent Office (EPO) | B1 | |
| AT380189TThis record | Austria | T | |
| DE602004010529D1 | Germany | D1 | |
| ES2297437T3 | Spain | T3 | |
| CN100422179C | China | C | |
| DE602004010529T2 | Germany | T2 |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Ceased as to paragraph 5 lit. 3 law introducing patent treatiesCeasedRER | RER |
Numbers
- Application
- 4741359
Titles2
- German
- 2-AMINO-5-BENZOYLTHIAZOL NPY-ANTAGONISTEN
- English
- 2-AMINO-5-BENZOYLTHIAZOL NPY ANTAGONISTS
Classification
- CPC, 7
- C07D417/12
- A61P3/04
- C07D277/42
- A61P3/10
- A61P19/02
- A61P25/18
- A61P43/00
- IPC, 5
- A61K31 426
- A61P3 04
- C07D277 42
- C07D277 56
- C07D417 12