AT378338T

Pyrrolopyridine derivatives and their use as crth2 antagonists

Abstract

A compound of formula (I) in free form or in salt form, gdeQ represents a bond or C1-C10-alkylene group optionally substituted by halogen; wherein R 1 and R 2 each independently presents an H, halogen, or C1-C8-alkyl, or wherein R 1 and R 2 together with the carbon atom to which they are attached, form a divalent C3-C8-cycloaliphatic group; wherein R3 is H, C1-C8-alkyl, C3-C15-carbocyclic group, C1-C8-haloalkyl, alkoxy C1 C8 alkyl, C1-C8-hydroxyalkyl; wherein R 4 and R 5 are, independently, halogen, C1-C8-alkyl, C1-C8-haloalkyl, C3-C15-carbocyclic group, nitro, cyano, C1-C8-alkylsulfonyl, C1-C8-alkylsulfinyl, C1-C8 alkylcarbonyl, C1-C8-alkoxycarbonyl, C1-C8C1-C8-alkoxy, C1-C8-haloalkoxy, carboxy, carboxy-C1-C8-alkyl, amino, C1-C8-alkylamino, di (C1-C8-alkyl) amino , SO2NH2, (C1-C8-alkylamino) sulfonyl, di (C1-C8-alkyl) aminosulfonyl, aminocarbonyl, C1-C8-alkylaminocarbonyl, di (C1-C8-alkyl) aminocarbonyl or a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; wherein R6 is H or C1-C8-alkyl; W is a C6-C15 aromatic carbocyclic group or a 4- to 10-membered heterocyclic group containing at least one ring heteroatom selected from the group consisting of nitrogen, oxygen and sulfur; X is -SO2-, -CH2-, -CON (C1-C8-alkyl) -, -CH (C1-C8-alkyl) - or a bond; where min each represent an average number of 0-3, and where p is 1. The application contains 9 claims.

Term

No projected expiry on record.

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0413619United KingdomA
0507693United KingdomA

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GB0413619D0United KingdomD0
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