Pyrrolopyridine derivatives and their use as crth2 antagonists
Abstract
A compound of formula (I) in free form or in salt form, gdeQ represents a bond or C1-C10-alkylene group optionally substituted by halogen; wherein R 1 and R 2 each independently presents an H, halogen, or C1-C8-alkyl, or wherein R 1 and R 2 together with the carbon atom to which they are attached, form a divalent C3-C8-cycloaliphatic group; wherein R3 is H, C1-C8-alkyl, C3-C15-carbocyclic group, C1-C8-haloalkyl, alkoxy C1 C8 alkyl, C1-C8-hydroxyalkyl; wherein R 4 and R 5 are, independently, halogen, C1-C8-alkyl, C1-C8-haloalkyl, C3-C15-carbocyclic group, nitro, cyano, C1-C8-alkylsulfonyl, C1-C8-alkylsulfinyl, C1-C8 alkylcarbonyl, C1-C8-alkoxycarbonyl, C1-C8C1-C8-alkoxy, C1-C8-haloalkoxy, carboxy, carboxy-C1-C8-alkyl, amino, C1-C8-alkylamino, di (C1-C8-alkyl) amino , SO2NH2, (C1-C8-alkylamino) sulfonyl, di (C1-C8-alkyl) aminosulfonyl, aminocarbonyl, C1-C8-alkylaminocarbonyl, di (C1-C8-alkyl) aminocarbonyl or a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; wherein R6 is H or C1-C8-alkyl; W is a C6-C15 aromatic carbocyclic group or a 4- to 10-membered heterocyclic group containing at least one ring heteroatom selected from the group consisting of nitrogen, oxygen and sulfur; X is -SO2-, -CH2-, -CON (C1-C8-alkyl) -, -CH (C1-C8-alkyl) - or a bond; where min each represent an average number of 0-3, and where p is 1. The application contains 9 claims.
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
63 members in 34 offices
Priority claims2
| Document | Office | Kind | Date |
|---|---|---|---|
| 0413619 | United Kingdom | A | |
| 0507693 | United Kingdom | A |
Members63
| Document | Office | Kind | |
|---|---|---|---|
| GB0413619D0 | United Kingdom | D0 | |
| GB0507693D0 | United Kingdom | D0 | |
| AU2005254681A1 | Australia | A1 | |
| CA2569125A1 | Canada | A1 | |
| WO2005123731A2 | World Intellectual Property Organization (WIPO) | A2 | |
| WO2005123731A3 | World Intellectual Property Organization (WIPO) | A3 | |
| PE20060301A1 | Peru | A1 | |
| TW200617009A | Taiwan Province of China | A | |
| AR049443A1 | Argentina | A1 | |
| ECSP067077A | Ecuador | A | |
| MXPA06014694A | Mexico | A | |
| NO20070323L | Norway | L | |
| EP1761529A2 | European Patent Office (EPO) | A2 | |
| KR20070032694A | Republic of Korea | A | |
| IL179604D0 | Israel | D0 | |
| MA28666B1 | Morocco | B1 | |
| CN101035786A | China | A | |
| EP1761529B1 | European Patent Office (EPO) | B1 | |
| AT378338TThis record | Austria | T | |
| HK1103730A1 | Hong Kong, China | A1 | |
| JP2008502638A | Japan | A | |
| BRPI0512060A | Brazil | A | |
| PT1761529E | Portugal | E | |
| TNSN06410A1 | Tunisia | A1 | |
| HRP20080022T3 | Croatia | T3 | |
| DK1761529T3 | Denmark | T3 | |
| ES2294717T3 | Spain | T3 | |
| PL1761529T3 | Poland | T3 | |
| SI1761529T1 | Slovenia | T1 | |
| US2008114022A1 | United States of America | A1 | |
| RU2007101277A | Russian Federation | A | |
| ZA200609527B | South Africa | B | |
| DE602005003365T2 | Germany | T2 | |
| AU2005254681B2 | Australia | B2 | |
| NZ551439A | New Zealand | A | |
| RU2379309C2 | Russian Federation | C2 | |
| US7666878B2 | United States of America | B2 | |
| RS50552B | Serbia | B | |
| US2010204225A1 | United States of America | A1 | |
| US2010210610A1 | United States of America | A1 | |
| DE602005003365D1 | Germany | D1 | |
| EP1761529B3 | European Patent Office (EPO) | B3 | |
| HRP20080022T4 | Croatia | T4 | |
| TWI352702B | Taiwan Province of China | B | |
| MY144903A | Malaysia | A | |
| PL1761529T6 | Poland | T6 | |
| JP4886680B2 | Japan | B2 | |
| ES2294717T7 | Spain | T7 | |
| CN101035786B | China | B | |
| DE602005003365T3 | Germany | T3 | |
| KR101183330B1 | Republic of Korea | B1 | |
| CA2569125C | Canada | C | |
| US8455645B2 | United States of America | B2 | |
| CY1107851T1 | Cyprus | T1 | |
| US8470848B2 | United States of America | B2 | |
| US2013267518A1 | United States of America | A1 | |
| IL179604A | Israel | A | |
| US8791256B2 | United States of America | B2 | |
| US2014309254A1 | United States of America | A1 | |
| US9169251B2 | United States of America | B2 | |
| NO338319B1 | Norway | B1 | |
| BRPI0512060B1 | Brazil | B1 | |
| BRPI0512060B8 | Brazil | B8 |
3 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Publication of translation of european patent specificationUEP | UEP | |
| Change in the person of patent ownerEEIH | EEIH | |
| Publication of translation of european patent specificationUEP | UEP |
Numbers
- Application
- 5751627
Titles2
- German
- PYRROLOPYRIDINDERIVATE UND DEREN VERWENDUNG ALS CRTH2-ANTAGONISTEN
- English
- PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS
Classification
- CPC, 11
- C07D471/04
- A61K31/437
- A61P11/00
- A61K45/06
- A61P11/08
- A61P11/14
- A61P25/00
- A61P29/00
- A61P37/00
- A61P37/08
- A61K31/4738
- IPC, 2
- C07D471 04
- A61K31 437