Ningalin b analogs employable for reversing multidrug resistance

(-- 57) summary -- drug resistance (MDR) is conquered using the analog of ニンガリン B lacking in peculiar cell obstacle activity, and the transformed cell containing a human colorectal cancer cell line (HCT116/VM46) is again made into susceptibility, for example about various cell obstacle agents, such as vinblastine and doxorubicin. Re-susceptibility-ization is attained by a low dose rather than ベラパミル which is an archetypal medicine. . The total synthesis of ニンガリンB and its analog is based on the heterocyclic アザジン Diels Alder strategy (1, 2, 4, 5-tetra-gin ->1, 2-Giadinh -> pyrrole) in which it was suitable ideal for construction of the pyrrole nucleus which is found out by the product of nature and to which the functional group was given with high density. It is attained using brief and efficient approach.