Conformationally constrained backbone cyclized somatostatin analogs

Analogue backbone cyclized somatostatin incorporating at least one structural unit containing said structural unit a nitrogen atom of the peptide backbone connected to a bridging group comprising amide, tióter, thioester or disulfide, wherein at least one structural unit connected via said bridging group to form a cyclic structure with a moiety selected from the group consisting of a second structural unit, the side chain of an amino acid residue of the sequence or the N-terminal amino acid residue having the following general formula 7: No formula 7 wherein n is 1 to 5; X represents a terminal carboxylic acid, an amide group or alcohol; Q is hydrogen or a mono- or disaccharide R5 is gamma-aminobutyric acid, diaminobutyric acid, Gly, beta-Ala, 5-aminopentanoic acid or amino hexanoic acid; R6 is (D) - or (L) -Phe or Tyr; R7 is (D) - or (L) -Trp, (D) - or (L) -Phe, (D) - or (L) - 1Nal or (D) - or (L) - 2Nal, or Tyr; R8 is (D) - or (L) -Trp; R9 is (D) - or (L) -Lys; R10 is Thr, Gly, Abu, Ser, Cys, Val, (D) - or (L) -Ala, or (D) - or (L) -Phe; R11 is (D) - or (L) -Phe, (D) - or (L) -Ala, Nle, or Cys; R12 is Gly, Val, Leu, (D) - or (L) -Phe or 1Nal or 2Nal;